Biomedical subjects

Youngja Park

Publications and source records attributed to Youngja Park.

2 recordsLinked to original sources

PubMed2004

Small cavitands specifically binding a water molecule.

[structure: see text] Three new C(2v) cavitands based on resorcin[4]arene bind water specifically at low temperature in CD(2)Cl(2) or CDCl(3) due to their complementarity to water as well as the solvophobic interaction. The averaged DeltaH(o) and DeltaS(o) values are -2.3 kcal mol(-1) and -128 cal mol(-1) K(-1), which gave the averaged -DeltaG(o) of 1.9 kcal mol(-1) at -50 degrees C in water saturated CD(2)Cl(2).

Journal Article↗

PubMed2003

Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.

A series of novel cyclopropyl nucleosides was synthesized using the highly stereoselective Simmons-Smith reaction starting from 1,2:5,6-di-O-isopropylidene-D-mannitol. The structural assignments of these nucleosides were determined by NMR studies and X-ray crystallography. All the synthesized nucleosides were assayed against several viruses.

Adenine↗