PubMed Health⌕ Search

Biomedical subjects

Yu-Sheng Chien

Publications and source records attributed to Yu-Sheng Chien.

2 recordsLinked to original sources

A novel microfluidic mixer utilizing electrokinetic driving forces under low switching frequency.

This paper presents a novel technique in which low-frequency periodic electrokinetic driving forces are utilized to mix electrolytic fluid samples rapidly and efficiently in a double-T-form microfluidic mixer. Without using any additional equipment to induce flow perturbations, only a single high-voltage power source is required for simultaneously driving and mixing the sample fluids which results in a simple and low-cost system for the mixing purpose. The effectiveness of the mixer as a function of the applied electric field and the periodic switching frequency is characterized by the intensity distribution calculated downstream from the mixing zone. The present numerical and experimental results confirm that the proposed double-T-form micromixer has excellent mixing capabilities. The mixing efficiency can be as high as 95% within a mixing length of 1000 microm downstream from the secondary T-junction when a 100 V/cm driving electric field strength and a 2 Hz periodic switching frequency are applied. The results reveal that the optimal switching frequency depends upon the magnitude of the main applied electrical field. The rapid double-T-form microfluidic mixer using the periodic driving voltage switching model proposed in this study has considerable potential for use in lab-on-a-chip systems.

Electrophoresis, Microchip↗

Microfluidic T-form mixer utilizing switching electroosmotic flow.

This paper presents a microfluidic T-form mixer utilizing alternatively switching electroosmotic flow. The microfluidic device is fabricated on low-cost glass slides using a simple and reliable fabrication process. A switching DC field is used to generate an electroosmotic force which simultaneously drives and mixes the fluid samples. The proposed design eliminates the requirements for moving parts within the microfluidic device and delicate external control systems. Two operation modes, namely, a conventional switching mode and a novel pinched switching mode, are presented. Computer simulation is employed to predict the mixing performance attainable in both operation modes. The simulation results are then compared to those obtained experimentally. It is shown that a mixing performance as high as 97% can be achieved within a mixing distance of 1 mm downstream from the T-junction when a 60 V/cm driving voltage and a 2-Hz switching frequency are applied in the pinched switching operation mode. This study demonstrates how the driving voltage and switching frequency can be optimized to yield an enhanced mixing performance. The novel methods presented in this study provide a simple solution to mixing problems in the micro-total-analysis-systems field.

Electrochemistry↗