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Yu-feng Wang

Publications and source records attributed to Yu-feng Wang.

11 recordsLinked to original sources
PubMed2006

[Association between serotonin 1D gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavior disorder].

OBJECTIVE: To investigate the relationship between two HTR1D gene polymorphisms, that is 1350T > C and 1236A > G polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid disruptive behavior disorder (DBD). METHODS: Blood samples were taken from 90 trios with probands of ADHD comrbid DBD and 182 trios with probands of ADHD not comorbid DBD. DNA was extracted. 1350T > C and 1236A > G were genotyped by restriction fragment length polymorphism analysis. Transmit/disequilibrium test and haplotype analysis were used to test the association of the two polymorphisms of HTR1D gene and ADHD comorbid or not comorbid disruptive behavior disorder (DBD) separately. RESULTS: 1350T allele(chi2 = 3.67, P = 0.055)and G/T haplotype(chi2 = 3.84, P = 0.050)were overtransmitted, while 1350C allele(chi2 = 3.67, P = 0.055) and G/C haplotype(chi2 = 5.22, P = 0.022)were undertransmitted to probands of ADHD with DBD. No biased transmission of any allele and haplotype was found in families with probands of ADHD without DBD. CONCLUSION: ADHD comorbid or not comorbid DBD are different at the level of HTR1D gene polymrohisms of 1350T > C and 1236A > G. The current results indicate that ADHD with DBD has more heritable backgrounds when compared with ADHD without DBD.

Adolescent↗
PubMed2006

[The relationship between early childhood caries and child temperament].

OBJECTIVE: To evaluate the differences in temperament between children with early childhood caries (ECC) and an age-matched children without ECC. METHODS: A total of 219 3-year-old children were selected in urban areas of Beijing, who were physically and mentally healthy. There were 109 children in ECC group, who had unfilled caries in 1 or more surfaces in primary maxillary anterior teeth, and 110 children without caries. The children were examined for ECC levels, and their parents were asked to complete the NYLS Temperament Scale questionnaire. Then the data was collected and analyzed. RESULTS: Children with difficult, intermediate high or slow-to-warm-up temperament had more severe caries than children with easy or intermediate low temperament. There was a significant difference in temperament attribute "Activity level" between male children with ECC and without ECC. There was a significant difference in temperament attribute "Rhythmicity" between female children with ECC and without ECC. CONCLUSIONS: There were some differences in temperament between 3-year-old children with ECC and without ECC in urban areas of Beijing.

Child, Preschool↗
PubMed2005

Differences between attention-deficit disorder with and without hyperactivity: a 1H-magnetic resonance spectroscopy study.

Using proton magnetic resonance spectroscopy ((1)H-MRS) to investigate possible neurometabolic differences between the predominantly inattentive subtype (ADHD-I), the combined subtype (ADHD-C) and normal controls. Proton spectra were acquired bilaterally on the lenticular nucleus in 20 schoolboys having ADHD and 10 matched controls. The boys with ADHD were divided into ADHD-C subtype (n=10) and ADHD-I subtype (n=10) according to DSM-IV criteria. The peaks of N-acetylaspartate (NAA), Choline moieties (Cho), myo-inositol (mI), creatine (Cr) and alpha-Glx were measured and their ratios to Cr were calculated. One-way ANOVA and post-hoc Bonferroni tests were used to detect the difference of the peak-area ratios of NAA, Cho, mI, and alpha-Glx to Cr among the three groups. There was a significant overall group difference in the NAA/Cr ratio both in the right and left lenticular nucleus (right: P=0.002; left: P=0.003). Only the ADHD-C subtype group showed a significant difference with controls (right: P=0.001; left: P=0.003) the right lenticular nucleus, the NAA/Cr ratio in the ADHD-C group was significantly lower than that in the ADHD-I group (P=0.012). In the left lenticular nucleus, the NAA/Cr ratio in the ADHD-C group showed a significant trend compared to the ADHD-I group (P=0.06). This study demonstrated the existence of measurable difference between children with ADHD-C and ADHD-I using (1)H-MRS.

Adolescent↗
PubMed2004

[Association between serotonin 2C gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid with learning disorder].

OBJECTIVE: To investigate the relationship between two HTR2C gene polymorphisms, that is C-759T and G-697C polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid learning disorder (LD). METHODS: Blood samples were taken from 189 trios with probands of ADHD comorbid LD (ADHD+LD) and 299 trios with probands of ADHD not comorbid LD (ADHD-LD). DNA was extracted and PCR was performed to amplify the fragments containing both C-759T and G-697C polymorphisms. Aci I was used to detect different alleles of the two polymorphisms. Allele- based and haplotype- based TDT analysis were used to test the association of the two polymorphisms of HTR2C gene and ADHD-LD and ADHD+LD. RESULTS: -759C(chi(2)=6.961, P=0.008), -697G(chi(2)=8.346, P=0.004), as well as -759C/-697G haplotype were over- transmitted(chi(2)=9.000, P=0.002 7), while haplotype -759T/-697C was under- transmitted(chi(2)=7.784, P=0.005 3) to probands with ADHD-LD. No biased transmission of any allele and haplotype were found in families with probands of ADHD+LD. CONCLUSION: ADHD-LD and ADHD+LD are different at the level of HTR2C gene polymrohisms of C-759T and G-697C. HTR2C is related to ADHD-LD, while not related to ADHD+LD.

Attention Deficit Disorder with Hyperactivity↗
PubMed2004

[A preliminary study on the attentional networks of attention deficit hyperactivity disorder].

OBJECTIVE: To investigate the efficiency of the three attentional networks in attention deficit hyperactivity disorder (ADHD). METHODS: Subjects were 25 children, aged 7 to 12 years, with DSM-IV ADHD and 25 non-ADHD controls matched by age, sex and IQ. Attentional networks tests were performed in all the subjects on an IBM compatible computer. RESULTS: No differences were found between the ADHD children and the normal controls in alerting and orienting effects. However, ADHD children had a significantly larger executive control effect than their normal counterparts. The general accuracy of the ADHD children was significantly lower than that of the normal controls. CONCLUSION: ADHD children may have impairments in their executive control network of attention.

Attention↗
PubMed2004

[Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children].

OBJECTIVE: To study the association of dopamine beta-hydroxylase gene 5' flanking region polymorphism-1021 C-->T with attention deficit hyperactivity disorder (ADHD) in Han children. METHODS: ADHD was diagnosed according to the DSM-IV criteria. DNA was extracted and PCR was performed to examine the DBH-1021C-->T polymorphism. HHRR was used to test the association of dopamine beta-hydroxylase gene with different subtypes of ADHD. RESULTS: HHRR results showed this polymorphism had a tendency to be associated with the inattention subtype (P=0.067) and the combined subtype (P=0.076). The T allele was the protective factor of the inattentive subtype (P=0.07), and the risk factor of the combined subtype (P=0.08). After dividing the 292 nuclear families according to sex, DBH-1021C-->T polymorphism was found to be associated with the combined subtype (P=0.04) with the T allele as the risk factor (P=0.02). There were no positive findings among the girl nuclear families of ADHD. CONCLUSION: DBH gene is related to ADHD combined subtype and inattention subtype. The genetic basis of ADHD combined subtype and is inattention is different, and is influenced by sex factor.

Adolescent↗
PubMed2004

[Effects of distractors on sustained attention in children with attention-deficit hyperactive disorder].

OBJECTIVE: Using an experimental design combining the sustained attention task (CPT, SART) and the flanker task, we investigated: 1) whether children with attention-deficit hyperactive disorder (ADHD) have deficits in their sustained attention; 2) whether distractors have different effects on response to targets at different sustained attention levels; 3) whether different subtypes of ADHD children show different patterns in sustained attention. METHODS: Subjects were recruited from elementary school (Grade 2 - 6). Twenty seven ADHD children (23 male, 4 female) and 29 normal controls (24 male, 5 female) were matched by IQ and age. The cognitive experiment measuring reaction times and error rates was conducted on a computer using DMDX software. ADHD and normal children's performance in sustained attention and the effect of distractors were analyzed, and the results of subtypes of ADHD were compared. RESULTS: ADHD children and normal children did not show significant differences in error rates in their response to dominant (non-attentional) item. However, distractors impaired ADHD children's response to targets. ADHD children also showed more errors than normal children in the sustained attention task, but compared with the non-distractor condition, distractors facilitated their response. CONCLUSIONS: ADHD children have deficits in their sustained attention, reflecting the deficits in brain development. More importantly, this study found that the effects of distractors in sustained attention can be dissociated according to the level of demand on sustained attention: distractors interfered with responses to targets when the demand on sustained attention was low, and they facilitated responses to targets when the demand on sustained attention was high. There were no significant differences between ADHD-inattentive type and ADHD-combined type in their deficits in sustained attention.

Attention↗
PubMed2004

[Association studies of G352A polymorphism of dopamine transporter gene in Han Chinese attention deficit hyperactivity disorder patients].

OBJECTIVE: To investigate association of the new polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 with attention deficit hyperactivity disorder (ADHD) in Han Chinese children. METHODS: The new mutant polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 was found by the fluorescently-labeled dye-terminators assay. The study samples were comprised of 337 ADHD children, 207 unrelated controls and 201 integrated ADHD trios (included proband and biological parents). Associations of polymorphisms with ADHD and its subtypes were examined by: (i) comparing cases and controls; and (ii) using family-based association study in transmission-disequilibrium test (TDT). RESULTS: The allele frequencies at the DAT1 G352A locus in the control samples were 79.5% for 352G and 20.5% for 352A respectively. Association studies revealed no association between G352A in exon 15 of DAT1 and ADHD. But after a stratification by gender, there was possible association between G352A and ADHD girls: the 352G allele had a tendency to be preferentially transmitted to ADHD girls. CONCLUSION: There is no association between G352A, the new polymorphism, in exon 15 of DAT1 and ADHD. The 352G allele has a tendency to be preferentially transmitted to ADHD girls, but the findings require replication before drawing a definitive conclusion.

Adolescent↗
PubMed2003

[Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder with or without learning disorder].

OBJECTIVE: To investigate the relationship between two tryptophan hydroxylasec (TPH) gene polymorphisms, A218C and A-6526G polymorphisms, and attention deficit hyperactivity disorder (ADHD) with or without learning disorder (LD). METHODS: Blood samples were taken from 132 trios with probands of ADHD with LD and 221 trios with probands of ADHD without LD. DNA was extracted and PCR was performed to amplify the fragments of A218C amd A-6526G polymorphisms. NheI and MboI were used to detect different alleles of the two polymorphisms separately. transmission disequilibriumtest (TDT) and haplotype analysis were used to test the association of the two polymorphisms of TPH gene and ADHD with or without LD. RESULTS: Haplotype block composed by A218C and A-6526G polymorphisms was related to ADHD with LD (chi(2) = 9.362, df = 3, P = 0.025). The haplotype of 218A/-6526G was significantly untransmitted to the probands with ADHD with LD (chi(2) = 9.252, df = 1, P = 0.002). CONCLUSION: TPH gene and the haplotype of 218A/-6526G may be related to ADHD with LD.

Adolescent↗
PubMed2003

[A nested case-control study on child sensory integrative dysfunction].

OBJECTIVE: To explore risk factors and protective factors of sensory integrative dysfunction (SID) among preschool and school children in Beijing, and to identify potential risk factors of SID. METHODS: Three hundred and ten kindergarten children were investigated twice in 1993 and 1999 by "The Child Sensory Integration Check List" and "General Information Questionnaire". A nested case-control study was carried out by single variable and multivariate conditional logistic regression analysis to find out the risk factors of SID. RESULTS: In the SID incidence group, the risk factors of SID were edema during pregnancy (OR = 7.06), paternal age (OR = 1.28), suffering from diseases before 3 years old (OR = 1.13), while the protective factor was family support network during school age (OR = 0.54). In the SID self-recovery group, the risk factors of SID were suspected attention-deficit hyperactivity disorder (ADHD) among maternal cousins (OR = 3.02), social ethos (OR = 1.69), consistency of parental discipline (OR = 1.45), while the protective factors were living condition and environment for entertainment (OR = 0.37), parental care during school age. In the SID negative group, the risk factors of SID were maternal contracted pelvis (OR = 3.45), less chance in enjoying audio and video entertainment during school age (OR = 1.98), suspected ADHD among paternal cousins (OR = 1.89), consistency of parental discipline (OR = 1.75), suspected ADHD among maternal cousins (OR = 1.48), paternal occupation during school age (OR = 1.19), while the protective factors were family support network (OR = 0.56) and maternal educational background (OR = 0.38) during preschool age. CONCLUSION: Our data showed that the risk factors of child SID were mainly associated with biological and genetic factors. Psychosocial factors seemed to be the secondary risk factors of SID.

Attention Deficit Disorder with Hyperactivity↗