[Chronic arsenic intoxication--a case report ].
Explore the source record for details and available documents.
Arsenic Poisoning↗
Biomedical subjects
Yu-guo Song
Publications and source records attributed to Yu-guo Song.
[Effects of chronic mercury poisoning on blood coagulation and fibrinolysis systems].
OBJECTIVE: To investigate the effects of chronic mercury poisoning on blood coagulation and fibrinolysis systems, and the possible mechanism. METHODS: Twenty-seven patients with chronic mercury poisoning were studied with 30 healthy people as control. Thrombomodulin (TM), tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), interleukin-13 (IL-13), interleukin-18 (IL-18), soluble intercellular adhesion molecule-1 (SICAM-1) were examined with ELISA methods, and superoxide dismutase (SOD) and lipid peroxidation (LPO) was examined with chemical catalysis methods. Two to three weeks after treatment with reduced glutathione, tiopronin and daidzein, blood was used for determin the above items again. RESULTS: (1) The concentration of TM in patients [(2.36 +/- 0.16) ng/ml] was significantly lower than in the control [(4.36 +/- 0.24) ng/ml] (P < 0.01), while TM tended to be higher after treatment [(4.82 +/- 0.34) ng/ml] (P < 0.05). (2) The concentration of t-PA in patients [(3.44 +/- 0.34) ng/ml] was significantly lower than in the control [(4.52 +/- 0.16) ng/ml] (P < 0.05), and was higher significantly [(5.63 +/- 0.58) ng/ml] after treatment (P < 0.05); The concentration of PAI in patients [(48.23 +/- 3.59) ng/ml] was significantly higher than in the control [(31.59 +/- 2.13) ng/ml] (P < 0.05), but after treatment no significant change [(50.71 +/- 4.29) ng/ml] was found (P > 0.05). (3) The activity of SOD in patients [(953.85 +/- 9.56) U/g Hb] was significantly lower than in the control [(1,308.75 +/- 10.21) U/g Hb] (P < 0.01), and was higher significantly [(1,217.95 +/- 6.29) U/g Hb] after treatment (P < 0.05); and the concentration of LPO in patients [(9.53 +/- 0.26) nmol/ml] was significantly higher than in the control (P < 0.05), and significantly lower [(7.29 +/- 0.35) nmol/ml] after treatment (P < 0.05). (4) The concentrations of IL-13 [(35.93 +/- 5.28) pg/ml], IL-18 [(28.79 +/- 2.53) pg/ml], SICAM-1 [(603.16 +/- 29.12) ng/ml] were significantly higher than those in the controls (P < 0.05, P < 0.01), but no significant difference was found after treatment. CONCLUSION: Dysfunction of the TM/protein C system and t-PA/PAI system (i.e. the decrease of anti-coagulation activity and the inhibition of the function for the fibrolysis system) may play a key role in the secondary hypercoagulable state induced by chronic mercury poisoning.
Adult↗
[Effect of push-pull maneuver on distribution of DNA and NO content in rats' brain tissue].
OBJECTIVE: To study the effect of push-pull maneuver on cerebral apoptosis and NO content of rats. METHOD: Ninety male Wistar rats were randomly divided into the control group, +Gz exposure group and the push-pull maneuver group. The rats were killed after 30 min exposure, 3 h, 12 h, 24 h or 48 h exposure, and the brain tissues were taken. The variation of NO content measured was using chemical colormetry. Then flow cytometric method was adopted to examine the distribution diagram of cortex and hippocampus-cell DNA for determination of percentage of A0 peak, which could express apoptosis degree. RESULT: NO content in +Gz exposure group and push-pull group are significantly different from that of control at 30 min, 3 h and 12 h. And the difference between +Gz group and push-pull group are also significant, but not at 24 h and 48 h. Comparing with the control group, the apoptosis amount of cortex and hippocampus-cell of +Gz exposure group and push-pull maneuver group increased obviously at 3 h, 12 h and 24 h, reached its peak at 24 h, and had no remarkable difference at 48 h. The comparison of the apoptosis amount of cortex cell and hippocampus cell between push-pull maneuver group and +Gz exposure group, difference at 3 h and 24 h and remarkably different at 12 h. CONCLUSION: High +Gz and push-pull maneuver may increase the percentage of cerebral apoptosis amount and NO content. Comparing with the +Gz exposure group, the push-pull maneuver group will cause more increase in apoptosis amount and NO content, but this damage is reversible.
Aerospace Medicine↗