Biomedical subjects

Yu-ying Zhao

Publications and source records attributed to Yu-ying Zhao.

At least 19 recordsLinked to original sources

PubMed2005

[A new natural product from the roots of Hedysarum multijugum].

OBJECTIVE: To study the chemical constituents of the roots of Hedysarum multijugum Maxim. METHODS: Compounds were isolated and purified by solvent and column chromatographic methods, and their structures were determined on the basis of physico-chemical properties and spectroscopic data. RESULTS: Seven compounds warangalone-4'-methyl ether (1), afrormosin (2), sissotrin (3) and ononin (4), naringenin-5, 7-di-O-beta-D-glucopyranoside (5), apigenin (6) and narcissin (7) were obtained from the roots of Hedysarum multijugum. CONCLUSION: Compound 1 is a new natural product, and other compounds; are obtained from the plant for the first time.

Apigenin↗

PubMed2005

An antitumor compound julibroside J28 from Albizia julibrissin.

A new triterpenoid saponin, julibroside J(28) (1), was isolated from the stem bark of Albizia julibrissin Durazz (Leguminosae) by using chromatographic method. The structure of 1 was established by spectroscopic methods. 1 displayed significant antitumor activity in vitro against PC-3M-1E8, Bel-7402, and HeLa cancer cell lines at 10 microM assayed by SRB method.

Antineoplastic Agents, Phytogenic↗

PubMed2005

Diastereoisomeric saponins from Albizia julibrissin.

The structures of four new diastereoisomeric triterpenoidal saponins Julibroside J5, J8, J12 and J13 (1-4) isolated from Albizia julibrissin Durazz. (Leguminosae) have been determined on the basis of comprehensive spectroscopic analysis and chemical degradation. Julibroside, J8 and J13 showed marked cytotoxic activities against Bel-7402 cancer cell line at 100 microg/mL.

Albizzia↗

PubMed2005

[Studies on the constituents of polysaccharide and the content of saccharide from Mongolian medicine Hara Buri-16].

This article describes the extraction of dissolvable polysaccharide from Hara Buri-16, and using phenyl hydrate-sulfuric acid to determine the content of dissolvable polysaccharide. The average recovery is 101.1% and RSD is 0.94%. The components of water soluble polysaccharide were identified by gas chromatography as: fucose, arabinose, xylose, mannose, galactose and glucose in the molar ratio of 0.57:6.67:0.46:6.61:2.47:4.80 respectively.

Arabinose↗

PubMed2005

[Chemical constituents of the rhizome of Matteuccia struthiopteris].

AIM: To study the chemical constituents of the rhizome of Matteuccia struthiopteris (L.) The constituents were separated and purified by column chromatography with normal Todaro. METHODS: phase silica gel and Sephadex LH-20. Their structures were identified on the basis of physical and spectral data (MS, NMR, HMBC and HMQC). RESULTS: Four compounds were isolated and identified as 1-O-beta-D-gl ucopyranosyl-(2S,3R,4E, 8Z) -2-N-(2'-hydroxydocosanoyl) eicosasphinga-4,8-dienine (1), 1-O-beta-D-galactosyl-(6-->1)-alpha-D-galactosyl-2,3-O-dihexadecanoyl-glycerol (2), succinic acid (3), D-mannitol (4). CONCLUSION: Compounds 1 and 2 are new compounds. Compounds 3 and 4 were isolated from this plant for the first time.

Ferns↗

PubMed2005

[Studies on chemical constituents in herbs of Acanthus ilicifolius].

OBJECTIVE: To study the chemical constituents of Acanthus ilicifolius. METHOD: Chromatographic methods were used to isolate compounds from A. ilicifolius, and chemical and spectral methods were used to elucidate the structures of the isolated compounds. RESULT: Five compounds, luteolin 7-O-beta-D-glucuronide (1), apigenin-7-O-beta-D-glucuronide (2), methylapigenin-7-O-beta-D-glucuronate (3), uridine (4) and uracil (5) were obtained. CONCLUSION: 1, 4 and 5 were obtained from the genus for the first time.

Acanthaceae↗

PubMed2005

[The megastigman glycosides from herb of Potentilla multifida].

OBJECTIVE: To investigate the chemical constituents of Potentilla multifida. METHOD: Various chromatographic techniques were employed for isolation and purification of the constituents. The structures were elucidated by spectral analysis. RESULT: Four megastigmane glycosides were isolated from P. multifida and their structures were identified as citroside A (1), icariside B1 (2), (6S,7E,9R)-roseoside (3), (6S,7E,9R)-vomifoliol-9-O-beta-D-xylopyranosyl-(1-->6)-O-beta-D-glucopyranoside (4), respectively. CONCLUSION: All compounds were obtained from the genus Potentilla for the first time.

Glycosides↗

PubMed2005

[Studies on lignan glycosides from the roots of Bupleurum scorzonerifolium].

AIM: To study the lignan glycosides from the roots of Bupleurum scorzonerifolium. Chromatography methods was used to isolate compounds and chemical and spectral methods were used to identify the structures of isolated compounds. RESULTS: Two lignan glycosides were isolated from the roots of B. scorzonerifolium and their structures were identified as 2, 3-E-2,3-dihydro-2-(3'-methoxy-4'-O-beta-D-glucopyranosyl-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl )-7-methoxy-1-benzo [b] furan (1) and 2, 3-E-2, 3-dihydro-2-( 3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-( 3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b]furan (2), both of them which were the mixture of (+)2S,3R- and (-)2R,3S-type diastereoisomer and in both of them the amount of (+)2S,3R-type was a little more than that of the (-)2R,3S-type. CONCLUSION: Compounds 1 and 2 were isolated from B. scorzonerifolium for the first time. (+)2S, 3R-2, 3-Dihydro-2-(3'-methoxy-4'-hydroxy-phenyl)-3-hydroxymethyl-5-(3"-hydroxypropenyl)-7-O-beta-D-glucopyranosyl-1-benzo[b] furan is a new compound.

Bupleurum↗

PubMed2004

[Isolation and identification of chemical constituents from Albizia julibrissin Durazz].

OBJECTIVE: To study the chemical constituents of the stem bark of Albizia julibrissin Durazz. METHODS: Chemical constituents were isolated by the repeated chromatography methods and their structures were identified by spectral analysis. RESULTS: Five compounds were obtained as follows: 3-O-[beta-D-xylopyranosyl-(1-->2)-beta-D-fucopyranosyl-(1-->6)-beta-D-glucopyranosyl]-21-O-(6S)-2-trans-2-hydroxy-methyl-6-methyl-6-O-beta-D-quinovopyranosyl-2,7- octadienoyl-acacic acid-28 -O-beta-D-glucopyran -osyl(1-->3)-[alpha-L-arabinofuranosyl (1-->4)]-alpha-L-rhamnopyranosyl(1-->2)]-beta-D- glucopyranosyl ester (1). acacigenin B (2) julibrotriterpenoidal lactone A (3) machaerinic acid lactone (4) acacic acid methylester (5). CONCLUSION: Compound 1 was isolated directly from this plant for the first time.

Albizzia↗

PubMed2004

[Studies on chemical constituents in rhizome of Matteuccia struthiopteris].

OBJECTIVE: To study the chemical constituents in rhizome of Matteuccia struthiopteris. METHOD: The compounds were isolated by normal phase silica gel chromatography. The structures were identified by physical and spectral data. RESULT: Six compounds were isolated and identified as woodwardic acid (1), ergost-6,22-diene-3beta,5alpha,8alpha-triol (2), apigenin (3), riboflavin (4), 4-O-beta-D-glucopyranosyl-p-coumaric acid (5), 4-O-beta-D-glucopyranosylcaffeic acid (6). CONCLUSION: All the compounds were obtained from this plant for the first time.

Apigenin↗

PubMed2004

[Structure identification of jujuboside D].

AIM: To study the chemical constituents of Ziziphus jujuba Mill var. Spinosa (Bunge) Hu ex. H. F. Chou. METHODS: To separate the constituents by using various kinds of chromatography and identify their structures on the basis of spectral analysis. RESULTS: Five compounds were isolated and their structures were established as jujuboside D (1), jujuboside A (2), 5,7,4'-trihydroxyflavonol-3-O-beta-D-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), 6'''-coumaroylspinosin (4) and phenylalanine (5). CONCLUSION: Compound 1 is a new compound named jujuboside D, 4 is reported as rotamer for the first time, 3 and 5 isolated from this plant for the first time.

Molecular Conformation↗

PubMed2004

[Studies on chemical constituents from root of Hedysarum polybotrys].

OBJECTIVE: To study the chemical constituents of Hedysarum polybotrys. METHOD: Chromatographic methods were used to isolate compounds from H. polybotrys and chemical and spectral methods were used to elucidate the structures of the isolated compounds. RESULT: Five compounds, N,N,N-trimethyl-tropaphone inner salt (hypaphorine) (1), octadecyl-3-methoxy-4-hydroxy-benzeneacrylate (2), 5,7,4'-trihydroxy-dihydroflavanone 5,7-di-O-beta-D-glucopyranoside (3), 3,4,5-trimethoxy cinnamic acid methy ester (4) and vanillic acid (5), were isolated from the roots of H. polybotrys. CONCLUSION: Compounds 1, 2 and 3 were obtained from this plant for the first time, while compounds 1 and 2 were isolated from Hedysarum for the first time.

Acrylates↗

PubMed2003

[Studies on chemical constituents of Hedysarum polybotrys].

AIM: To study the chemical constituents of Hedysarum polybotrys Hand.-Mazz.. METHODS: The compounds were separated with Sephadex LH-20 and silica gel column chromatography, and their structures were identified on the basis of spectral analysis. RESULTS: Five compounds were identified as hedysalignan A (1), isoliquiritigenin (2), formononetin (3), calycosin (4) and ononin (5). CONCLUSION: Hedysalignan (1) is a new compound and the others were obtained from the plant for the first time.

Chalcone↗

PubMed2003

[Structure identification of jujuboside E].

AIM: To study the chemical constituents of the seeds of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex. H.F. Chou. METHODS: To separate the constituents by using various kinds of chromatography methods and identify their structures on the basis of spectral analysis. RESULTS: Seven compounds were isolated. Their structures were established as jujuboside E (1), jujuboside B (2), jujuboside A (3), betulic acid (4), stearic acid (5), sucrose (6) and inosine (7). CONCLUSION: Compound 1 is a new compound named jujuboside E. Compounds 5, 6, 7 were isolated for the first time from this plant.

Inosine↗

PubMed2003

[Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].

OBJECTIVE: To find out substance basis of pharmacological activities of Angelica sinensis. METHOD: Chromatographic methods were used to isolate the chemical components, and spectroscopic methods were used to identify their structures. RESULT: Five compounds were isolated from the ethanol extract of the roots of Angelica sinensis. Their structures were identified as: (Z)-ligustilide, (Z)-6,7-epoxyligustilide, (Z)-6,7-cis-dihydroxyligustilide, (E)-6,7-cis-dihydroxy-ligustilide and 11-angeloylsenkyunolide F. CONCLUSION: 11-angeloylsenkyunolide F was obtained from Angelica sinensis for the first time.

4-Butyrolactone↗

PubMed2002

[Studies on flavoniod constituents of Hedysarum multijugum].

AIM: To study the chemical constituents from Hedysarum multijugum. METHODS: The compounds were separated by chromatography methods, their structures were identified by spectral analysis. RESULTS: Six compounds were isolated and identified as beta-sitosterol (1), 7-hydroxy-4'-methoxy isoflavone (2), betulic acid (3), 1,7-dihydroxy-3, 9-dimethoxy pterocarpene (4), 5, 7-dihydroxy-8-C-prenyl-4'-methoxy isoflavone (5) and 5, 7-dihydroxy-4'-methoxy isoflavone (6). CONCLUSION: Compound 4 is a new compound and the others were obtained from the plant for the first time.

Benzofurans↗

PubMed2002

[Studies on water-soluble constituents of Echinacea prupurea].

AIM: To study the water-soluble constituents of Echinacea purpurea. METHODS: The compounds were isolated by chromatography method and their structures were identified on the basis of spectral analyses. RESULTS: Five compounds were identified as 2-(4-hydroxylphenyl)-ethyl-O-alpha-L-rhamnopy-ranoasyl-(1-->6)-beta-D- glucopyranoside, named echipuroside A 1); (6S, 9R)-6-hydroxy-3-one-alpha-inonol-9-O-beta-D-glucopyranoside 2), ampelopsisionoside 3); phenylmethyl-6-O-beta-D-xylopyranosyl(1-->6)-beta-D-glucopyranoside 4) and phyenylmethyl-beta-D-glucopyranoside 5). CONCLUSION: Compound 1 is a new compound, the others were isolated from this plant for the first time.

Cyclohexanones↗

PubMed2002

[Studies on the phenylpropanoids from Eucommia ulmoides].

OBJECTIVE: To study the chemical constituents from the leaves of Eucommia ulmoides. METHOD: The constituents were isolated by chromatography method and the structures were identified on the basis of spectral analysis. RESULT: Six compounds, ursolic acid(1), beta-sitosterol(2), p-coumaric(3), caffeic acid ethyl ester(4), chlorogenic acid(5) and syringin(6) were obtained. CONCLUSION: Compound 3, 4, 5 were obtained from the plant for the first time.

Caffeic Acids↗