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Yuichiro Tsunemi

Publications and source records attributed to Yuichiro Tsunemi.

40 records · Page 3Linked to original sources
PubMed2002

A keratin 9 Gene mutation (Asn160Ser) in a Japanese patient with epidermolytic palmoplantar keratoderma.

We described a 5-year-old Japanese girl with epidermolytic palmoplantar keratoderma and examined her for a keratin 9 gene mutation. Physical examination disclosed diffuse yellowish hyperkeratosis with an erythematous border limited strictly to the palms and soles. Histological examination revealed hyperkeratosis with vacuolar degeneration in the spinous and granular layers of the epidermis. Sequence analysis demonstrated an A to G transition at the middle position of codon 160 in the 1A domain of the keratin 9 gene. The amino acid at codon 160 was deduced to have changed from asparagine (Asn) to serine (Ser). This is the first case with an Asn160Ser mutation in a Japanese. The substitution of Ser for Asn at codon 160 of the keratin 9 gene is assumed to be fatal for keratin filament assembly regardless of race or ethnicity.

Asian People↗
PubMedDate not supplied

Ultraviolet A irradiation inhibits thymus and activation-regulated chemokine (TARC/CCL17) production by a human keratinocyte HaCaT cell line.

Ultraviolet A (UVA) irradiation modulates the immunological functions of skin. We examined the effect of UVA irradiation on the basal and the IFN-gamma-and TNF-alpha-stimulation-induced production of thymus-and activation-regulated chemokine (TARC/CCL17) using HaCaT cells. UVA irradiation inhibited the basal levels of both TARC mRNA expression and TARC protein production. UVA irradiation also significantly inhibited TARC mRNA expression and TARC protein secretion that were induced by co-stimulation with IFN-y and TNF-alpha. A time course study showed that: the significant suppression of TARC mRNA expression was detected 8 hours after irradiation and continued for 36 hours; the strongest inhibition of TARC protein secretion occurred in the first 8 hours after UVA irradiation and continued for 36 hours. Our data provide the first evidence that UVA inhibits TARC mRNA expression and TARC protein production by keratinocytes in a dose-dependent manner. These results may suggest an explanation for the UV-induced therapeutic effect.

Cell Line↗
PubMedDate not supplied

Eccrine angiomatous hamartoma with massive mucin deposition.

Eccrine angiomatous hamartoma (EAH) is a rare condition characterized histologically by an increased number of eccrine structures and numerous vascular elements. Although EAH sometimes shows mucinous stroma, the mucin is usually not abundant. In this report, we described a case of EAH that had massive mucin deposition, especially around the eccrine structures. Our case and a similar reported one indicate that EAH includes a rare variant with a large amount of mucin as one of the hamartoma components.

Adult↗