PubMed Health⌕ Search

Biomedical subjects

Yuki Sakai

Publications and source records attributed to Yuki Sakai.

6 recordsLinked to original sources
PubMed2006

Neuro-Behçets/neuro-Sweets disease presents simultaneously with severe tonsillitis, and features mimicking bacterial meningitis with skin lesions.

The patient was hospitalized due to rapidly undulant fever and sore throat. Empirical antibiotic therapy was started, however, headache also occurred. Lumbar puncture disclosed polynuclear leukocyte-predominant pleocytosis indicating that the patient suffered from bacterial meningitis. The antibiotics therapy was increased, however, consciousness became impaired and erythema multiforme-like skin lesions appeared. T2-weighted brain magnetic resonance imaging showed high signal intensity in the brainstem. HLA testing revealed B54 and Cw1. The patient presented futures of Behçets disease at the same time as those of Sweets syndrome and it was difficult to distinguish between the two diseases. Administration of prednisolone showed remarkable effect.

Adult↗
PubMed2006

Bone-conducted auditory brainstem-evoked responses and skull vibratory velocity measurement in rats at frequencies of 0.5-30 kHz with a new giant magnetostrictive bone conduction transducer.

CONCLUSIONS: A new giant magnetostrictive bone conduction transducer (GMT) measuring 8 mm (length) by 2 mm (diameter) is capable of outputting sounds over a wider range of frequencies than conventional electromagnetic transducers (EMTs). The GMT can vibrate the rat skull about 3-100 times faster than the EMT, especially above 2 kHz. OBJECTIVES: Since the GMT can generate high sound quality and output sounds above 10 kHz, we investigated the width of the frequency response of the GMT and evaluated its mechanical performance. MATERIALS AND METHODS: We chose Wistar rats to estimate the GMT performance by measuring the bone-conducted ABR and the skull vibratory velocity because their hearing frequency range extends from 0.15 kHz to 67 kHz. We also measured the bone-conducted auditory brainstem responses (ABRs) and the skull vibratory velocity of rats with the EMT. Skull vibratory velocity was measured with a laser Doppler vibrometer (LDV). RESULTS: The skull vibratory velocity at the ABR threshold obtained with each transducer was within the -35 to -50 dB range (0 dB re 1 mm/s). When 1 Vpp was applied to each transducer, the GMT had a higher velocity at frequencies of 2-30 kHz, and the EMT at frequencies of 0.5-1 kHz.

Animals↗
PubMed2004

Hearing evaluation in two sisters with a T8993G point mutation of mitochondrial DNA.

We report on two sisters with a T8993G point mutation of mitochondrial DNA, and their hearing evaluation. Considering auditory function, hearing in the elder sister remains almost normal. However, in the younger sister, the auditory brainstem response (ABR) threshold has fluctuated remarkably during a 3-year follow-up. The threshold changes of ABR in the younger sister suggest that her hearing problems may well be caused by both cochlear nerves and retrocochlear lesions. Our experience is clinically important because there have been only a few reports on hearing evaluation in patients with a T8993G point mutation of mitochondrial DNA.

Audiometry, Pure-Tone↗
PubMed2002

Auditory brainstem responses and usefulness of hearing aids in hearing impaired children with Cornelia de Lange syndrome.

OBJECTIVE: To examine auditory brainstem evoked responses (ABRs) of children with Cornelia de Lange syndrome (CDLS) to evaluate hearing and the utility of hearing aids in hearing impaired cases. SUBJECTS AND METHODS: Thirteen Japanese infants and children with CDLS were studied. Behavioral observation audiometry and ABR were used to evaluate hearing. RESULT: Four different ABR patterns at 85 dB clicks were observed: no response in either ear (6 patients); clear ABRs in both ears (2 patients); no response in one ear but ABRs recorded in the other ear (3 patients); and no peaks after wave III in one ear and ABRs recorded in the other ear (2 patients). However, in 2 patients with no response in either ear at the first measurement, ABRs were recorded in one ear within 2 years. Three out of 13 patients exhibited better responses to sound through the use of hearing aids and auditory training. CONCLUSIONS: The fitting of hearing aids and early consistent training have a significant effect on auditory development in CDLS children in terms of making them aware of sound localization and the different types of environmental sound.

Audiometry↗
PubMed2002

Detachable forceps for flexible fibre-optic surgery: a new technique for phonosurgery in cases where rigid laryngoscopy is contraindicated.

In phonosurgery, in cases where it is not possible to use a rigid laryngoscope, a flexible fibrescope with laryngeal-mask ventilation may be used. In flexible fibreoptic surgery, the forceps are normally inserted through a small channel in the fibrescope. Since only a small forceps tip can pass through this channel, a limited range of forceps has been available for use in fibrescope procedures. We have developed a new type of forceps for flexible fibre-optic surgery that allows this size limitation to be overcome. The new forceps is made up of two parts: (i) the forceps tip and its control wire assembly, and (ii) a detachable handle. A wide range of forceps can be used, including those with tips larger than the biopsy channel. We report a case that was treated with this new technique.

Adult↗