Relieving anxiety by entering the operating room on foot.
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Biomedical subjects
Yuko Kojima
Publications and source records attributed to Yuko Kojima.
Hyoid bone position change after neck dissection for oral cancer: a preliminary report.
PURPOSE: The study goal was to evaluate the change in hyoid bone position after neck dissection and tumor resection for oral cancer. PATIENTS AND METHODS: Twenty-seven patients who underwent surgery were retrospectively evaluated. The hyoid bone position was measured before and after the surgery using a topogram of computed tomography scans. RESULTS: There was a statistically significant difference in the hyoid bone position between preoperative and postoperative images in anteroposterior direction (Wilcoxon signed rank test, P <.05), but there was no significant difference in the superoinferior direction. The hyoid bone moved anteriorly when the submandibular region was resected. In cases in which the submental region was resected, it was variably displaced depending on the type of suspension or reconstruction of the resected suprahyoid muscles. CONCLUSION: This limited study suggests that the hyoid bone is displaced after surgery for oral cancer. The hyoid bone was displaced anteriorly if the submandibular region was resected, and it was displaced severely if the submental region was resected.
Adult↗
A New Family of Indoaniline-Derived Calix[4]arenes: Synthesis and Optical Recognition Properties as a Chromogenic Receptor(1).
A new family of indoaniline-derived calix[4]arenes has been synthesized for the purpose of developing a new chromogenic receptor. A condensing reaction of calix[4]arene (1) with 4-(diethylamino)-2-methylaniline hydrochloride (2) in the presence of an oxidizing agent under alkaline conditions affords mono- (3), 1,2-bis- (4), 1,3-bis- (5), and tetrakisindoaniline-derived (6) calix[4]arenes after careful column chromatography. Compound 3 is crystallized from a CHCl(3)-MeOH solution, and the crystal structure was determined by X-ray analysis. The crystal is monoclinic, space group P2(1)/n, Z = 4, a = 19.507(6) Å, b = 18.591(6) Å, c = 8.524(2) Å, beta = 94.69(2) degrees. The final R value for 2406 reflections of F(o) > 3sigma(F(o)) is 0.085. A unique intramolecular hydrogen-bonding network involving the carbonyl oxygen of indoaniline for 3 implied that the quinone carbonyl group as an acceptor of the chromophore can easily be subjected to an electrostatic interaction in the lower rim. Indeed, 1,3-bis(indoaniline)-derived 2,4-bis((ethoxycarbonyl)methoxy)calix[4]arene 7, prepared by the reaction of 5 with ethyl bromoacetate in the presence of NaH, is capable of undergoing an efficient ion-dipole interaction between the binding cation and the two quinone carbonyl groups of the chromophores, so that a selective Ca(2+)-induced pronounced color change (wavelength change > 100 nm) occurs with an association constant on the order of 10(6) in 99% EtOH, making 7 of potential use as an optical sensor for Ca(2+) detection. The IR and NMR studies have indicated that Ca(2+) is encapsulated in the cavity made by the distally located OCH(2)CO(2) groups on the lower rim of the cone-shaped calix[4]arene segment. Interestingly, however, the shape of the cavity in which Ca(2+) has been encapsulated does not have a C(2) axis of symmetry, as inferred from the (1)H-(1)H COSY experiment. On the other hand, 1,2-bis(indoaniline)-derived analogue 8 shows no response with metal ions, which can be interpreted to mean the absence of a cavity for encapsulation on the lower rim.
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