A case of adult-onset Felty syndrome in juvenile rheumatoid arthritis.
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Adult↗
Biomedical subjects
Yun-Woo Lee
Publications and source records attributed to Yun-Woo Lee.
Monostotic Paget's disease of the tibia in Korea.
The incidence of Paget's disease has been estimated to be about 3%, but it is extremely rare in Asia, especially in Korea. In addition, monostotic involvement seems to be far less frequent. In this report, we describe a case of monostotic Paget's disease localized in the right tibia.
Alkaline Phosphatase↗
Expression of platelet-derived growth factor in the developing cochlea of rats.
OBJECTIVE: Platelet-derived growth factor (PDGF) is involved in the control of cell proliferation, differentiation and survival in various tissues of vertebrates. However, little is known about the expression of PDGF in the developing cochlea of rodents. MATERIAL AND METHODS: We examined the expression of PDGF family genes in the developing cochlear tissue of rats using microarrays and tested their role in the proliferation of progenitor hair cells using cellular and molecular biology techniques. RESULTS: It was found that the genes for PDGF-A, PDGF receptor (R)-alpha and PDGFR-beta were highly expressed in the rapidly growing otocyst on embryonic Days 12-14 and weakly expressed thereafter. Reverse transcriptase polymerase chain reaction demonstrated the expression of PDGF-C and confirmed the expression of PDGF-A and PDGFR-alpha and -beta in the developing cochlear tissue of rats and the cultured progenitor hair cells. Inhibition of the expression of PDGFs in the cultured progenitor hair cells with antisense oligonucleotides reduced the DNA synthesis. CONCLUSION: PDGFs and their receptors may play a role in the proliferation of developing cochlear hair cells.
Animals↗
Tuberculous fasciitis in scleroderma.
A 25-year old woman visited the hospital because of a painful swelling for 20 days in the midposterior portion of her right thigh. She had been diagnosed with systemic sclerosis and treated for 10 months. An MRI scan of the right thigh showed diffuse fascial thickening and involved the superficial portion of thigh muscles, which were hyperintense on the T(2)-weighted image. A biopsy of the involved muscles revealed chronic granulomatous inflammation with several acid-fast bacilli on a Ziehl-Neelsen stain. We here report a case of tuberculous fasciitis manifest with painful swelling of the midposterior muscles of the right thigh without pulmonary tuberculosis in a patient with scleroderma.
Adult↗
Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis.
OBJECTIVE: To determine the efficacy of local therapy with human angiostatin gene in murine collagen-induced arthritis (CIA). METHODS: DBA/1 mice were immunized with bovine type II collagen. Before the onset of arthritis, NIH3T3 fibroblasts, transduced with angiostatin-expressing retroviral vectors or control vectors, were transplanted into the knee cavity. The incidence of arthritis in the knee joints was evaluated histologically based on pannus formation and cartilage destruction. Paws were evaluated macroscopically for redness, swelling, and deformities and immunologically for levels of interleukin-1 beta. Angiogenesis in paws and knee joints was studied by immunohistochemistry using anti-CD31 antibody and measurement of von Willebrand factor levels. RESULTS: Pannus formation and cartilage erosion were dramatically reduced in knees transplanted with angiostatin-expressing cells. In addition, the onset of CIA in the ipsilateral paws below the knees injected with the angiostatin gene was significantly prevented. Furthermore, angiostatin gene transfer inhibited arthritis-associated angiogenesis. CONCLUSION: Local production of angiostatin in the knee was able to prevent the onset of CIA not only in the knee injected with genetically engineered cells, but also in the uninjected ipsilateral paw. This suggests that transfer of the angiostatin gene, and potentially also its protein, may provide a new, effective approach to the treatment of rheumatoid arthritis.
3T3 Cells↗