Biomedical subjects

Yuxia Cui

Publications and source records attributed to Yuxia Cui.

4 recordsLinked to original sources

PubMed2024

Gene-environment interactions within a precision environmental health framework.

Understanding the complex interplay of genetic and environmental factors in disease etiology and the role of gene-environment interactions (GEIs) across human development stages is important. We review the state of GEI research, including challenges in measuring environmental factors and advantages of GEI analysis in understanding disease mechanisms. We discuss the evolution of GEI studies from candidate gene-environment studies to genome-wide interaction studies (GWISs) and the role of multi-omics in mediating GEI effects. We review advancements in GEI analysis methods and the importance of large-scale datasets. We also address the translation of GEI findings into precision environmental health (PEH), showcasing real-world applications in healthcare and disease prevention. Additionally, we highlight societal considerations in GEI research, including environmental justice, the return of results to participants, and data privacy. Overall, we underscore the significance of GEI for disease prediction and prevention and advocate for integrating the exposome into PEH omics studies.

Humans↗

PubMed2003

Application of toxicity identification evaluation procedures to an effluent from a nitrogenous fertilizer plant in China.

The integrated method combining chemistry and toxicology, toxicity identification evaluation (TIE), was conducted to identify key toxicants in an effluent from a nitrogen fertilizer plant in China. Toxicity characterization, phase I of TIE, revealed that the suspected toxicant in the effluent was an anion that could be changed into a volatile acid. The results of toxicity identification and confirmation procedures indicated potassium cyanide to be the primary toxicant in the effluent.

Algorithms↗

PubMed2003

[Toxicity identification evaluation on efficiency of chemical effluent treatment].

Acute toxicity tests of the effluents from both inlet and outlet of the treatment system in a chemical plant in Jiangsu Province were conducted with Daphnia magna. The results showed that both effluents were toxic to this species. Toxicity identification evaluation (TIE) was used to identify the key toxicants in the effluent before and after treatment. The results indicated that Cu2+ was the key toxicant causing the toxicity of input water, and some metals and polar organics were the coexistent toxicants in the water. The toxicity of output water was caused by some toxic organics, which were easy to be oxidized under acidic conditions. The results also showed that the toxicity removal efficiency reached 77.6% through the treatment process. It could be seen that the effluent treatment process in this plant had a higher efficiency of removing heavy metals, but the removal rate of organic compounds was quite low. It was concluded that the production techniques and the effluent treatment process of this plant were not perfect, and needed to be improved.

Animals↗

PubMed2002

[Advances in the ecological risk management of pollution point sources of toxicants in aquatic environment].

Progress in this field in developed countries and China was reviewed and the prospects were also presented in this paper. Based on the water quality standards and discharge standards, the chemical-specific approach in common use could not effectively control complex discharges containing toxic organics. Therefore, applying this traditional approach only was not a valuable measure. Toxicity-based approach could be used at the same time to supply the gap for the control of complex discharges containing toxic organics effectively based on the requirements of ecological risk management. Toxicity identification evaluation (TIE) for identifying the key toxicants causing the effluent ecotoxicity was a core of the ecological risk management of point sources of toxics. The prospects were also described for the development of TIE methodology and the application of toxicity-based approach to the ecological risk management of point sources of toxicants in aquatic environment in China.

Ecology↗