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Biomedical subjects

Z A Topchiashvili

Publications and source records attributed to Z A Topchiashvili.

At least 19 recordsLinked to original sources
PubMed2005

[Comparative analysis of cell populations with a phenotype similar to that of mesenchymal stem cells derived from subcutaneous fat].

Two cell populations with a phenotype similar to that of mesenchymal stem cells (MSC) with different characteristics for expression of surface antigene CD34 were derived from subcutaneous fat. CD34-positive cells were derived from subcutaneous fat of the inferior eyelid obtained during transconjuctival blepharoplasty. CD34-negative cells were derived from adipose tissue obtained during lipoaspiration from the same patients. These cells displayed common characteristics for morphology and expression of basic markers characterizing them as mesenchymal stem cells. On being induced for differentiation, these two cell populations were able to differentiate to cells of adipose (adipocytes), bone (osteoblastes, osteocytes), cartilage (chondroblasts, chondrocytes), and nervous (neurons, astrocytes and oligodendrocytes) tissues.

Antigens, CD34↗
PubMed2004

[Comparative effectiveness of different methods of diagnosis and correction of impaired portal circulation].

The diagnostic effectiveness of X-ray radionuclide and ultrasound determination of portal blood flow and the impact of different treatments on the blood flow were evaluated in 76 patients with hepatic cirrhosis. The treatment regimens were used propranolol (Group 1), isosorbide-5-mononitrate (monosan) (Group 2), and a combined therapy with propranolol in combination with diuretics and a course of intravenous laser irradiation (Group 3). In terms of both clinical and laboratory parameters and the status of portal circulation, the highest effect was observed in the patients receiving the combined therapy.

Antihypertensive Agents↗
PubMed1999

[Reoperations on biliary tracts].

Analysis of treatment of 386 patients in whom a total of 922 operations on biliary ducts were carried out is presented. In 201 patients biliary ducts' strictures were of iatrogenic origin, neglected stones of ducts were in 68 patients, neolithiasis--in 35 patients, the others had inflammatory lesions of the ducts. In cases of high strictures the operation of choice should be hepato--or hepaticojejunostomy with isolated intestinal loop.

Adolescent↗
PubMed1990

[Treatment of acute destructive pancreatitis].

The authors analyse observations over 113 patients (1978-1988) with destructive pancreatitis; there were 54 males and 59 females, whose ages ranged from 18 to 85 years. Complex nonoperative treatment was effective only in 17 patients. Cholecystectomy, cholecystostomy or choledochotomy was performed in 7 patients after their condition had improved. Eighty-eight patients underwent operation in the acute period. Total lethality was 71.6%. In summarizing the results the authors came to the conclusion that operative interventions should be postponed in clinical practice. The optimal time for the operation is 6-9 days after the onset of the disease.

Acute Disease↗
PubMed1984

[Spontaneous internal biliary fistulas].

Experience with the treatment of 137 patients with spontaneous internal biliary fistulas of different etiology is presented. Questions of clinical course, preoperative diagnoses and operative technique are discussed.

Adult↗
PubMed1984

[Cholelithic intestinal obstruction].

Analysis of the treatment of 25 patients with cholelithic intestinal obstruction is given. Questions of etiology, variants of the development, clinical course, diagnosis, operative treatment of the cholelithic ileus, causes of lethal outcomes are discussed. The authors propose measures of prophylactics .

Aged↗
PubMed1979

[Analysis of the lethality in cholecystitis and the ways for its decrease].

An analysis of lethality in cholecystitis has been carried out. The main complications, which had resulted in the death of 238 patients, were analysed. Purulent complications served as the most common cause of fatal outcome. The authors came to the conclusion on the necessity to broaden indication for an early surgical intervention in acute cholecystitis in elderly patients.

Adult↗