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Z Andelković

Publications and source records attributed to Z Andelković.

11 recordsLinked to original sources
PubMed1993

Significance of sacroiliac index in diagnostics of seronegative spondyloarthropathies.

Sacroiliac index (SI index) was determined by the quantitative scintigraphy in 106 patients:28 with ankylosing spondilitis, 51 with Reiter's disease, 9 with psoriatic, 18 with unclassified seronegative spondylarthropathy and in 20 controls. For the right joint, statistically significant difference was found between the control group SI-index value and the one in patients' group (p < 0.001 to p < 0.005) except in patients with psoriatic spondylarthropathy. Analysing each group of patients separately, statistically significant difference between the SI index of both left and right joint was present only in the group with Reiter's disease (t = 2.08: p < 0.05). Increased SI-index was found in 45.28% of all patients and this also confirmed sensitivity of the applied method, while the value of test specificity was 86.96%. Correlation between sedimentation rate and SI index as well as between radiographic finding and SI index was not present. There was a positive correlation between clinical findings and Reiter's disease but only in 56% of cases. It was concluded that scintigraphy is a useful but insufficient method in the diagnosis of seronegative spondylarthropathies.

Adolescent↗
PubMedDate not supplied

[The antiphospholipid syndrome in systemic connective tissue diseases].

The aim of the study was to prove the incidence of antiphospholipid syndrome (APS) in systemic connective tissue disease (SCTD), especially in systemic lupus erythematosus (SLE) and to find out serologic markers of APS. Of 94 patients with SCTD followed up in the last three years 80 had SLE, 7 Sjogren's syndrome, 3 systemic vasculitis, 2 combined systemic connective tissue disease, 1 rheumatoid arthritis, 1 Sjogren's syndrome with vasculitis. Antiphospholipid antibodies (ApSt) were determined by ELISA method. In 31 of 80 patients with SLE (38.07%) antiphospholipid antibodies were proved. In lo of 31 (32.26%) signs of systemic lupus or the presence of APS markers have not been found, while 21 of 31 (67.74%) had some of clinical manifestations of APS (most commonly thrombocytopenia or vascular thrombosis) with evolution of the basic disease. Among our patients with SLE the most common finding was IgG antibody isotype-in 14 or 66.66% of cases. In 5 of 7 patients with Sjogren's syndrome ApAt were proved without clinical evolution of the basic disease and APS. Only 2 of 7 patients of this group showed, together with more increased ApAt, mild evolution of the basic disease and manifestation of APS (livado reticularis and recurrent venous thrombosis).

Antiphospholipid Syndrome↗
PubMedDate not supplied

[Reiter's syndrome--analysis of 187 patients].

The study included 187 patients with positive diagnosis of Reiter's syndrome (RS) examined and treated in the Clinic of Rheumatology of Military Medical Academy in the period of 26 years (1970-1995). There were 176 males and 11 females (16:1) aged from 12 to 65 (average age 28.5) years. The disease diagnosis was made upon the clinical finding of at least two of four RS main features: acute urogenital or enteral infection, arthritis, ophthalmic and mucocutaneous changes. Family disease occurrence was noticed in 5, and juvenile type in 6 patients. HLA-B27 antigen was present in 81.5% patients. In 74.3% patients the urogenital disease type was determined, in 18.2% enterocolitic and in 7.5% initial causative agent was not discovered. Three or two RS main signs were present in approximately same number of patients (42.2% and 42.6%) while all the four disease signs were found in 15% patients. Acute or subacute course was found in 43.8%, recurrent in 34.2% and chronic in 22% patients. Clinically, the disease was revealed in locomotor system, most frequently as the asymmetric oligoartritis localized in lower extremities. Sacroiliac arthritis, partial or more frequently asymmetric mutual, radiologically confirmed, was present in 18.2% patients. Only one patient was with sacroiliitis without peripheral arthritis, pain in heel was present in 31.5%, and dactilitis, more frequently in the feet, in 13.9% patients. Radiological changes were found in 51.8% patients, most frequently in sacroiliac joints and heel bone. Chlamydia trachomatis or genital mycoplasma were isolated in synovial fluid of 33.3% (6/18) patients. The most frequent urogenital change was urethritis (56.7), ophthalmic--conjunctivitis (46.5), and mucocutaneous--balanitis (12.3). Positive damage of heart and kidneys by primary disease was found in 2, i.e. 4 patients, and possible in 7, i.e. 14 patients. No differences in RS clinical demonstration among sexes were observed. Besides conventional therapy, in only 26 (13.9%) patients were applied drugs out of the basic group, so as the radiation synovectomy and surgical methods of treatment.

Adolescent↗