Biomedical subjects

Z B Yuan

Publications and source records attributed to Z B Yuan.

7 recordsLinked to original sources

PubMed2001

[Application of capillary electrophoresis in the analysis of pesticides].

Capillary electrophoresis has proved to be a suitable microseparation technique for the analysis of a wide variety of chiral and achiral pesticides. In this paper, the applications and developments in the field of pesticide separation by HPCE are reviewed with 50 references, including different operating models and chiral agents. Furthermore, the advantage and trend of development are also pointed out.

Chromatography, Micellar Electrokinetic Capillary↗

PubMed2000

On-column amperometric detection in capillary electrophoresis with an improved high-voltage electric field decoupler.

An improved fabrication method for a decoupler for on-column amperometric detection in capillary electrophoresis (CE) is described. The decoupler is fabricated by etching one side-wall of the capillary with hydrofluoric acid after the polymer coating had been etched by laser, then the etched hole is sealed with adhesive. The steady time, electric conductivity efficiency and performance are investigated. On-column amperometric detection by CE of para-substituted phenols was carried out by coupling with a carbon-fiber microelectrode (10-microm diameter) and a practical small electrochemical detection cell.

Electrochemistry↗

PubMed1998

Comparison of high-performance capillary electrophoresis and liquid chromatography on analysis of zinc 5-aminosalicylate dihydrate and related materials.

Separation and determination of zinc 5-aminosalicylate dihydrate (ZASA) and related materials by high-performance capillary electrophoresis (HPCE) and liquid chromatography (HPLC) have been studied systematically. The R.S.D. of peak time and area and detection limits of materials were lower in HPLC compared to HPCE. HPCE and HPLC were used for determining ZASA and related materials in crude and treated ZASA using acid and heat, and similar results with both techniques showed the principal impurities in the crude ZASA were 5-aminosalicylic acid (ASA) and salicylic acid (SA), the compounds from ZASA decomposing under conditions of acid and heat were ASA, p-aminophenol and 5-benzeneazosalicylic acid.

Aminophenols↗

PubMed1998

A reproducible, simple, and sensitive high-performance capillary electrophoresis method for simultaneous determination of capreomycin, ofloxacin and pasiniazide in urine.

Separation and determination of capreomycin (Cp), ofloxacin (Oflx) and pasiniazide (Ipa) in urine by high-performance capillary electrophoresis (HPCE) with 280 nm detection have been studied systematically. The calibration lines were linear in the range of 0.5 approximately 50 mg 1(-1), and the detection limits (S/N = 3) were 0.15, 0.20 and 0.10 mg 1(-1) for Cp, Oflx and Ipa, respectively. The recoveries for these materials from urine were higher than 93.5%. The accuracy and intra- and inter- day reproducibility of Cp, Oflx and Ipa were determined with satisfactory results. This method was successfully used for determining Cp. Oflx and Ipa in human urine.

Aminosalicylic Acid↗

PubMed1997

[Investigation on electrochemical behavior of emodin and its application].

Emodin showed a second-order derivative reduction wave with peak potential of -0.75 V (SCE) by single sweep oscillopolarography using H3BO3-Na2B4O7 (pH 8.50) as base solution. The peak height of emodin is proportional to the concentration in the range of 1.42 x 10(-7)-5.7 x 10(-6) mol.L-1 and 7.1 x 10(-6)-7.1 x 10(-5) mol.L-1, respectively. The detection limit is 0.7 x 10(-7) mol.L-1. It can be employed for the determination of emodin in Rheum officinale Baill with satisfaction. The electrochemical behavior of emodin was studied and the electrode reaction mechanism was proposed. In addition, it was found that emodin, aloe-emodin, chrysophanol, rhein and physcion can scavenge superoxide anion radical produced by the autoxidation of pyrogallol. The scavenging activity is in the order: emodin > aloe-emodin > chrysophanol > rhein > physcion.

Anthraquinones↗

PubMed1996

Separation of five antipyretic analgesics by micellar electrokinetic capillary chromatography.

The derivatives of antipyrine and phenylbutazone are important antipyretic analgesics commonly used in clinical medicine. Although high performance liquid chromatography has been the conventional method used for the analysis of these drugs, in recent years capillary electrophoresis was validated to be a useful method in the analysis of antipyretic analgesics. However, there has been no report on the separation of antipyrine (AP), 4-aminoantipyrine (4-AAP), aminopyrine (APY), dipyrone (DIP) and phenylbutazone (PHE) in the literature. In this paper, a micellar electrokinetic capillary chromatographic (MECC) separation method was described for the five antipyretic analgesics.

Aminopyrine↗

PubMedDate not supplied

Comparison of high performance capillary electrophoresis and liquid chromatography for the determination of acyclovir and guanine in pharmaceuticals and urine.

High-performance capillary electrophoresis (HPCE) and high-performance liquid chromatography (HPLC) were developed and applied to the determination of acyclovir (ACV) and guanine (G) in pharmaceuticals. The comparison study showed that two methods gave comparable results in linear range, recovery and reproducibility. HPCE was used for the determination of ACV and G in urine; the recovery was better than 81.3% and the RSD was less than 4.4%.

Acyclovir↗