Intravenous pulse cyclophosphamide therapy in Crohn's disease and ulcerative colitis.
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Cyclophosphamide↗
Biomedical subjects
Z Barta
Publications and source records attributed to Z Barta.
Restriction enzyme analysis of ribosomal DNA shows that Candida inconspicua clinical isolates can be misidentified as Candida norvegensis with traditional diagnostic procedures.
We identified 29 yeast isolates from 22 patients using the API ID32C panel. Twenty-eight of these isolates were Candida norvegensis and one was C. inconspicua. Although C. norvegensis is considered a pseudohypha-producing species, only one isolate produced pseudohyphae. Restriction enzyme analysis of PCR-amplified ribosomal DNA with four different enzymes proved that all isolates were C. inconspicua.
Candida↗
Collagenous colitis: constipation or diarrhoea?
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Colitis↗
[Anti-Saccharomyces cerevisiae antibodies in patients with Crohn's disease].
Inflammatory Bowel Diseases are a group of diseases with chronic inflammation of the gastrointestinal tract, but without proven etiology. Immunologic, environmental, infective and genetic factors equally can play role in their development. Antibodies to an oligomannose epitope of the Saccharomyces cerevisiae demonstrated in 60-70% of the patients with Crohn's disease. The origin and the clinicopathological role are not clarified. It is important that there are no surveys with patients suffering in gluten sensitive enteropathy in the literature. As there are no ASCA survey in Hungary, the aim of this study was to determine the prevalence of the ASCA. The authors examined at their patients the ASCA's occurrence and compared with the clinical picture of the Crohn's disease. The results supported the theory that ASCA positivity correlates with small intestines' Crohn's disease and in these cases both the IgG and IgA type antibodies proved. The antibodies in the sera at the analyzed ASCA positive cases prove a systemic immune response against Saccharomyces cerevisiae and the authors suggest the end of the oral tolerance against the yeast's antigens. The diet restriction (elemental diet, total parenteral nutrition, and fecal diversion) may ameliorate the status of the patients with Crohn's disease. It is speculated that the yeast-free diet as a part of the therapy for the ASCA positive patients can be reasonable: moreover the permanent "forbidding" of the yeast can be an acceptable alternative in case of getting well.
Adult↗
EEG frequency profiles of idiopathic generalised epilepsy syndromes.
UNLABELLED: The objective of this study was to investigate EEG frequency profiles (topographic distribution of spectral power data) in well-defined idiopathic generalised epilepsy (IGE) syndromes: juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), epilepsy with grand mal seizures on awakening (EGMA), and in the unified 'common IGE' (CIGE) group of these patients. METHODS: Absolute and relative (percent) power values were computed from waking EEG activity by Fast Fourier Transform (FFT). Each patient group was compared to an age-matched group of healthy control persons. RESULTS: There was a general tendency for diffuse (absolute and relative) delta-theta-alpha power excess and relative beta power deficit in all IGE groups as compared to controls. Statistically significant (P</=0.05) bilateral absolute power differences were: fronto-parietal delta and diffuse theta (in JAE), frontal delta (in JME) and frontal alpha (in EGMA). Statistically significant (P</=0. 05) relative power differences were: frontal delta, diffuse theta, fronto-centro-parietal beta (in JAE), frontal delta and beta (in JME) and fronto-central alpha (in EGMA). The CIGE group showed power alterations of the same type but differences were statistically more significant than in the other patient groups. CONCLUSION: Absolute power findings were interpreted as enhanced neuronal synchrony in the 0.5-12.0 Hz frequency range together with the tendency of decreasing synchrony in faster (12.5-32.0 Hz) frequencies. Corresponding shifts in relative power were interpreted as reflecting dysfunction of cortical regions. The authors hypothesise that these IGE frequency profiles reflect widespread cortical dysfunction essentially common to all the investigated IGE syndromes.
Adolescent↗
[Association of carcinoid tumor of the appendix and Crohn disease (case report and review of the literature)].
The authors describe the coexistence of the carcinoid of the appendix and Crohn's disease. In the case of their woman patient the carcinoid was identified with the examination of the resected ileoascendent part of the bowel resulting of the complication of the Crohn's disease. 10 similar association is known in the literature but none of the patients had the signs of the carcinoid syndrome. Subsequent adrenerg syndrome after an alimentary hypoglycemia (increased evacuation of the cathecolamines and their metabolites in the urine), food allergy (increased IgE type antibody to milk protein) or gastroenteropancreatic (GEP) neuroendocrine tumor (based on the result of the 111In-octreoscan and the increased 5-hydroxyindolaceticaciduria) equally suspected of the symptoms (palpitation, flush) manifested after the operation. They look for the connection between the genesis of the intestinal carcinoid and the Crohn's disease with working up the bibliography. Summing up the references with a view of the latest it can be stated that the carcinoid of the appendix occurs more than orders of magnitude in the samples from inflamed surrounding than the samples from autopsy (0.24%--820/338,000 inflamed appendix and 0.03%--19/53,430 appendix from autopsy). Consequently the inflammation create favourable condition for the development of the carcinoid of the appendix.
Adult↗
[Observation in two cases of Whipple disease].
The authors survey the literature of Whipple's disease and present two of their patients. They assure that Whipple's disease in either associated with or is a result of an immunopathological clinical picture, but it is else possible that assumed pathogen, the Tropheryma whippleii itself alters the immune system. In the case of their female patient with active disease they showed the rearrangement of the bcl-2 gene [t(14; 18)] in her peripheral blood lymphocytes, while in their male patient in remission this could not be proved. During the observation, in their female patient insulin dependent diabetes mellitus (IDDM) developed. In connection with these cases, the authors draw the attention to the varied symptoms which are characteristic of autoimmune disease, and to the immunoserological laboratory differences in particular the rearrangement of the bcl-2 gene.
Adult↗
Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD).
BACKGROUND: Lipoid pneumonia is a rare pulmonary disease, a form of pneumonia that has no classical radiological appearance, thus it can imitate other lung diseases. Lipoid pneumonia is usually classified into two major groups, depending on whether the source of oil/fat in the respiratory tract is from an exogenous or endogenous source. Undifferentiated connective tissue disease is a term used by rheumatologists to define a group of diffuse connective tissue disorders that lack definitive characteristics of any particular well-defined disorder. MATERIAL AND METHODS: A case study is reported of concomitant undifferentiated connective tissue disease and endogenous lipoid pneumonia. RESULTS: Histologically the macrophages appeared filled with lipid and were similar to atherosclerotic foam cell macrophages. Antibiotic and antimycotic treatments were ineffective. However, with concomitant steroid treatment, the patient exhibited absence of lung infiltration as well as other symptoms and was discharged. Therefore it is concluded that the lipoid pneumonia was steroid dependent. CONCLUSION: Since the patient's condition responded to steroid treatment, and it is clear that steroids inhibit phospholipase activity, the authors speculate that the subsequent decreased endoperoxide production may diminish lipid uptake by macrophages via decreasing modification of LDL or other lipid sources.
Adult↗
Neuroborreliosis in county Baranya, Hungary.
The incidence and clinical characteristics of Lyme neuroborreliosis (NB) in a region of high prevalence of tick-bite in Hungary is described. In the county Baranya 66 patients were recorded in a five-year period (1989-93). Fifty-six patients (85%) were in "early", and 10 patients (15%) in "late stage" of NB. The sex distribution was equal. The incidence of NB was 2.9-100,000/year in this region. The incidence of radiculitis/neuritis, meningitis, encephalitis and myelitis in the sample was 56.1%, 19.7%, 18.2% and 6%, respectively. The EEG and evoked potentials showed both central and peripheral neural involvement, EMG and ENG abnormalities were related to the peripheral clinical signs. Non-specific white matter lesions could be found by MRI in 5 patients with central involvement. Cerebrospinal fluid changes were not obligatory but a better indicator of inflammatory process in cases with meningitis and/or encephalitis forms (positivity 75%) than in cases with myelitis and radiculitis (positivity 49%).
Adolescent↗