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Biomedical subjects

Z Bayraktaroğlu

Publications and source records attributed to Z Bayraktaroğlu.

7 recordsLinked to original sources
PubMed1999

Efficiency of some in vitro allergy tests for evaluating atopy in children and adults.

In recent years, an increase in the prevalence of allergic diseases has been reported, in industrialised countries. It is also a problem in non-industrialised countries, but its extent is less well documented. In this study, inhalant screening allergens (AlaTOP), food screening allergens (FP5E), and total and specific IgE were measured in 237 allergic patients (164 adults and 73 children) in order to examine the distribution of common allergens, the percentage of atopy/non-atopy among allergic children and adults in a developing country, Turkey, which has different environments and societies from western countries. We also evaluated the efficiency of automatic allergy screening tests in both groups. The sensitivity and specificity of AlaTOP in adults were 83% and 86%, respectively; these were 70% and 84%, respectively for FP5E, and the sensitivity and specificity of AlaTOP in children were 79% and 82%, while sensitivity and specificity of FP5E were 72% and 85%, respectively. The percentages of atopic male children (31%) were higher than in adults (21%). The reverse is true in adults. The most frequent allergens in childhood were Lolium perenne and cow milk, while in adults it was Lolium perenne. Total IgE levels were found to be statistically different between atopic and non-atopic subjects in adults (p < 0.001). This relationship was not found in children (p > 0.05). The sensitivity and specificity of total IgE in children were 57% and 67%, and in adults 84% and 67%, respectively. The lower specificity and sensitivity of total IgE level in children than in adults suggests that it is less useful for the diagnosis of allergy.

Adult↗
PubMed1997

Coronary risk factors in Turkish school children--report of a pilot study.

In 432 school children aged 7-15 years we investigated the following parameters; body mass index, blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. Only 2.8% of children were considered to be obese. Of the children, 3.5% had systolic, 4.9% had diastolic and 3.9% had both blood pressures higher than the acceptable age- and sex-stratified values. The mean total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were 3.37, 1.93 and 1.33 mmoll-1, respectively. In 31 (7.1%) of the children, total cholesterol levels were found to be above the risk cut-off level of 4.4 mmoll-1; in 39 (9%) of the children, low-density lipoprotein cholesterol levels were elevated above an acceptable upper limit of 2.84 mmoll-1. Significantly reduced high-density lipoprotein cholesterol values were observed in 8.8%. Mean total cholesterol and low-density lipoprotein cholesterol values were elevated significantly in hypertensive cases, while high-density lipoprotein cholesterol levels showed no difference. Sensitivity and the positive predictive value for selected total cholesterol cut-off points for determining elevated low-density lipoprotein cholesterol were 67% and 54%, respectively. These levels of risk are considerably lower than those found in studies in Western countries.

Adolescent↗
PubMedDate not supplied

Kawasaki disease associated with gallbladder hydrops.

Kawasaki disease is an acute, febrile, systemic syndrome of unknown etiology which principally affects young children. We present a five-year-old boy, who developed an unusual finding, acute hydrops of the gallbladder, in addition to the characteristic signs and symptoms of Kawasaki disease. Clinical features of the disease and treatment regimens, including early administration of intravenous gamma globulin (IVGG), which prevents cardiac complications, are discussed.

Child, Preschool↗
PubMedDate not supplied

Whistling face (Freeman-Sheldon) syndrome in two siblings.

Two siblings with typical manifestations of whistling face (Freeman-Sheldon) syndrome (WFS) born to unaffected parents are presented. In Case 1, deep-set eyes, epicanthus, blepharophimosis, right lid ptosis, strabismus, anti mongoloid slant, small mouth, mask-like face, high-arched palate, nasal speech, dysphagia, kyphosis and minimal scoliosis were noted, while Case 2 displayed blepharophimosis, mask-like face, long philtrum, high-arched palate, scoliosis, bilateral post-axial polydactyly of the feet and pes varus. We corrected the blepharophimosis in Case 1 by bilateral canthotomy and canthoplasty. This syndrome is usually inherited as an autosomal dominant trait; however, some authors have reported an autosomal an autosomal recessive form of this syndrome similar to our cases. Nevertheless, this could be explained by genetic expression of the mutant gene.

Child↗
PubMedDate not supplied

Immunoglobulin isotypes and IgG subclasses in recurrent infections.

The frequency of major immunoglobulin isotype and IgG subclass deficiencies among 74 children aged six months to 14 years with recurrent infections was studied. All children had at least five to six episodes of respiratory tract infections, while recurrent diarrhea had occurred in eight. Two selective and six partial IgA deficiencies were detected. IgG4, IgG3 and IgG2 deficiencies, either isolated or combined, were found in 13, nine and one patient respectively. Among these there were two combined deficiencies of IgA + IgG4, three of IgA + IgG3, one of IgA + IgG2 + IgG4, one of IgG1 + IgG3 and two of IgG1 + IgG4. There was one patient with panhypogammaglobulinemia. Our results, similar to those of other studies, showed that the occurrence of the Ig isotype, particularly subclass deficiencies, is not uncommon in children with frequent infections.

Adolescent↗