PubMed Health⌕ Search

Biomedical subjects

Z Csizér

Publications and source records attributed to Z Csizér.

At least 19 recordsLinked to original sources
PubMed1985

Changes in the tendency of lymphocytes to undergo blastic transformation in the postoperative period, in immune-stimulated and untreated colonic tumour patients.

A study was made of the blastic transformation of lymphocytes in the postoperative period in colonic tumour patients: 23 who had been immune-stimulated by vaccination, and 28 who had not been vaccinated. The immune reactivity decreased significantly in the majority of the cases; however, the deterioration of the immune status affected 68% of the nonvaccinated group, but only 48% of the vaccinated group. The data indicate that the vaccination primarily averted the deterioration of the defence ability in the early postoperative period in patients with a normal preoperative immune activity. An evaluable change in the immune reactivity did not occur in the 6-10 preoperative days following vaccination. Three months postoperatively, the number of patients giving a normal immune reaction was three-fold in the vaccinated than in the non-vaccinated group.

Colonic Neoplasms↗
PubMed1979

Potency of PPD preparations derived from M. tuberculosis and M. bovis.

No significant difference was found between the biological activity of PPD-preparations derived from M. tuberculosis and M. bovis, although the latter was more potent. In potency tests performed in guinea-pigs, the use of difference mycobacteria as sensitizing agents had no influence on the result of the assay. We could not demonstrate a significantly greater potency of homologous versus heterologous PPD. Evaluation of the 95 p.c. fiducial limits established in the course of variance analysis suggested a greater reliability of reading at 48 than at 24 hrs after allergen application. It also seems possible that the results of the potency assays of PPDs derived from different mycobacterium strains are greatly influenced by the level of the working dilutions employed.

Animals↗
PubMed1979

Biological standardization of potency testing of diphtheria-tetanus-pertussis vaccines.

Active protection tests were introduced for the potency testing of the toxoid components of the DTP vaccine. The standardization of these tests is described, with special attention on WHO requirements. A freeze-dried, adsorbed DTP vaccine was prepared for use under tropical or subtropical conditions. The potency testing of the components of this vaccine is presented in this paper.

Animals↗
PubMed1978

Demonstration of non-capsulated Haemophilus influenzae in the tissues of the respiratory tract in atopic and non-atopic subjects by means of an immunofluroescence technique.

The use of an immunofluorescence method for demonstration of non-capsulated H. influenzae colonization and penetration in the tissues of the respiratory tract seems to be a useful and convenient laboratory method. However, in in the tissues of the lower respiratory tract H. influenzae in our materials could not be demonstrated.

Fluorescent Antibody Technique↗
PubMed1978

Preparation and laboratory testing of plain and aluminum hydroxide-adsorbed cholera vaccines used in a field trial in Indonesia.

TWO TYPES OF CHOLERA VACCINE WERE PREPARED: a plain vaccine and an aluminium hydroxide-adsorbed vaccine, by using the Inaba NIH 35A3 and Ogawa NIH 41 serotypes of Vibrio cholerae. For cultivation, a solid medium was used and the cultures were inactivated with 0.02% thiomersal and by heating for 1 hour at 56 degrees C. The final vibrio concentration of the vaccines was adjusted to 16 x 10(9) vibrios/ml (equal proportions of the two serotypes). The antigenicity of the vaccines was assessed by the active mouse protection test and by the antibody production test, i.e. by determinating the vibriocidal antibodies in the sera of immunized mice. The results of the active mouse protection test showed that the antigenicity of the Inaba and Ogawa components of both vaccines met the WHO Requirements. The antigenicity of the Inaba component of both vaccines was about the same. The antigenicity of the Ogawa component of the plain vaccine appeared to be somewhat higher than that of the adsorbed vaccine. In the antibody production test, the adsorbed vaccine elicited a higher and longer-lasting immune response than the plain vaccine.

Adjuvants, Immunologic↗
PubMed1976

Stability of mammalian tuberculin PPD.

Six lots of PPD prepared in 1937 met the requirements when tested in guinea pig potency assay in 1974. Reading of the skin reactions at 48 hr gave more consistent results than the 24 hr reading. Data were evaluated by analysis of variance and by a quick method developed for the estimation of identity of the standard and the test preparation. Although less sensitive than the analysis of variance, the quick method has been found suitable for estimation of the potency of tuberculin preparations.

Analysis of Variance↗
PubMed1975

Standardization of housedust allergen in human skin test trials.

Standardization was carried out by comparison of Bencard and our own ('Human') housedust allergens in human skin test trials. The dose response curves on hypersensitive patients were parallel, linear, and there was no difference between preparations according to the variance analysis. The relative potency was 1.33 compared to the Bencard allergen. 95% confidence limits were 0.29-2.37. The correlation coefficient evaluated from all data was 0.90. Our experience suggests that human skin test trials seem to be a simple and convenient method for the standardization of housedust allergens. According to the results of analysis of factorials, data suitable for standardization can be obtained if the area of both the wheal and flare as different parameters are recorded 10 and/or 20 minutes after the intradermal injections.

Allergens↗
PubMed1975

A quick method for the estimation of the potency of tuberculin purified protein derivative in guinea pig.

By the statiscal analysis of the data the linear regression equation and standard deviation of the dose response function of the Hungarian Reference Purified Protein Derivative of Tuberculin (HR--PPD) have been determined. From the values of reaction diameters of the HR-PPD and of their standard deviation a diagram was plotted that can be used to estimate the identity of test material by comparison with the reference preparation. The diagram meets the condition that the limits of the standard deviation of the reference and test materials together are wider than the predetermined limits of +/-20%. The inaccurate titrations can be detected with its help at once. Using the diagram, the potency of test material can be promptly estimated in the biological assay of tuberculin made in guinea pig.

Animals↗
PubMed1975

Factors influencing the stability of acid-precipitated polyvalent Bordetella pertussis bulk suspensions.

According to the statistical analysis of the potency values of acid precipitated polyvalent bulk suspensions of Bordetella pertussis, the potency of suspensions decreased below 8 IU/30 IOU during storage for 5 to 9.8 years. The average annual decrease over a 13-year period was 2.03 IU/30 IOU. The periodicity in the decrease of potency values was assumed to be connected with changes in the quality of the casein hydrolysate ingredient of the medium. Periodic functions employed to approach potency values with limits of 1 SD falling within the range of 64--156% indicated that the potency decreased below 8 IU/30 IOU after 9 years.

Acids↗