[Familial idiopathic fibrosing alveolitis].
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Biomedical subjects
Publications and source records attributed to Z Czakó.
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The role of antibiotics in the therapeutical result and in the postoperative complications was studied after 557 thoracic operations. It was found that antibiotics have no decisive role in the therapeutic result and there was no difference in the incidence of wound infections between the groups treated with different antibiotics. The principles and practice of treatment of would infections and pyothorax are discussed in detail. No relationship was found between the incidence of postoperative respiratory complications and the various drug treatments. Prevention and treatment of postoperative respiratory complications are discussed. The length of the febrile period was independent of the antibiotics applied. Their time of application, the problem of changing drugs and their side-effects after thoracic operations are analyzed.
The antibiotic level in the serum, pericardial fluid and myocardium of 11 patients prepared for heart surgery was tested by means of the agar-diffusion method after the intramuscular administration of 1 g of methicillin. The mean level after 1 to 3 hours was 14.7 mcg/ml in serum, 1.7 mcg/ml in the pericardial fluid and 8.2 mcg/g in the myocardium. In the case of drug sensitivity, the myocardial methicillin concentration is sufficient for the treatment of Gram-positive infections. If the infection is localized in the pericardium, higher doses, local applications, drug combination or complex therapy might be called for.
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This report is concerned with a patient successfully operated for Holt-Oram syndrome. The disorder is inherited dominantly with complete penetrance and variable expressivity. It is pointed out that in cases of congenital heart disease familial cumulation must be borne in mind which can easily be verified by pedigree investigation. After demonstrating autosomal dominant inheritance, suitable inferences must be drawn for genetic counseling. Attention is drawn to the heart-surgical significance of the rhythm disorders so often associated with the syndrome.
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