Chinese center sues over study coverage.
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Academies and Institutes↗
Biomedical subjects
Z Dan
Publications and source records attributed to Z Dan.
[A clinical study on vaccine of Mycobacterium vaccae in treating pulmonary tuberculosis].
OBJECTIVE: To study the effect of vaccine of Mycobacterium vaccae on cell-mediated immunity and on treating patients with pulmonary tuberculosis. METHODS: Seventy cases of pulmonary tuberculosis with smear positive and initial treatment were classified randomly into group I (35 cases) and group II (35 cases), receiving 2HRZS/4HR and 2HRZS/4HR plus vaccine of Mycobacterium vaccae regimens respectively. Thirty-one multi-drug resistant pulmonary tuberculosis cases were classified into group III, receiving 4 - 6 sensitive antituberculous drugs and vaccine of Mycobacterium vaccae. Improvement of clinical symptoms, resolution of pulmonary lesions, negative conversion of sputum and changes of immunological functions were observed. RESULTS: No significant difference in improvement of symptoms was found in group I and group II (P > 0.05), and the improvement rate of clinical symptoms in group III was found more than 50%. X-ray resolution rates in 4th month were 83% and 89%, and cavity reducing rates 40% and 50% respectively in group I and group II, and no significant differences were found (P > 0.05). X-ray resolution rate was 29%, cavity reducing rate 7% and no deteriorated case was found in group III. Sputum negative conversion rates in 1st, 2nd, 3rd and 4th month were 23%, 51%, 83% and 97% respectively in group I, while 31%, 77%, 89% and 100% in group II, and 3%, 16%, 29% and 32% in group III. Significant difference was found between group I and group II in sputum negative conversion rate in 2nd month after treatment (P < 0.05). After treatment, values of lymphocyte transformation test (LTT), CD(3), CD(4) and CD(4)/CD(8) of the above 3 groups were all higher than that before the treatment (P < 0.05), level of tumor necrosis factor decreased in group II and IL-2, IL-6 increased in group III. CONCLUSIONS: Vaccine of Mycobacterium vaccae is a good immunotherapy preparation, which promotes sputum negative conversion and activation of cell-mediated immunity.
Adolescent↗
Ultrastructural identification of cells involved in the healing of intramembranous and endochondral bones.
This study was designed to identify the cells involved in the healing of autogenous intramembranous (IM) and of endochondral (EC) bone grafts. Thirty-six defects were created in the skull of 18 adult New Zealand White rabbits. Defects were filled with IM graft alone, EC graft alone, demineralized bone matrix (DBM) alone, or combined DBM-IM and DBM-EC bone. Cellular identification was carried out at 7 and 14 days by light and electron microscopy. In IM bone, preosteoblasts, osteoblasts, and osteocytes were observed with no cartilage intermediate stage, while in EC bone, chondroblasts and chondrocytes were observed. DBM implant and DBM-IM were characterized by the presence of a cartilage stage. In conclusion, IM bone healed through an osteogenic ossification route, while EC bone healed through an EC ossification route. In the presence of demineralized EC bone matrix, IM bone adopts an EC ossification route.
Animals↗
Study of natural diamonds by dynamic nuclear polarization-enhanced 13C nuclear magnetic resonance spectroscopy.
The results of a study of two types of natural-diamond crystals by dynamic nuclear polarization (DNP)-enhanced high-resolution solid-state 13C nuclear magnetic resonance (NMR) are reported. The home-built DNP magic-angle spinning (MAS) 13C NMR spectrometer operates at 54 GHz for electrons and 20.2 MHz for carbons. The power of the microwave source was about 30 W and the highest DNP enhancement factor came near to 10(3). It was shown that in the MAS spectra the 13C NMR linewidths of the Ib-type diamond were broader than those of IaB3-type diamond. From the hyperfine structure of the DNP enhancement as a function of frequency, four kinds of nitrogen-centred and one kind of carbon-centred free radicals could be identified in the Ib-type diamond. The hyperfine structures of the DNP enhancement curve that originated from the anisotropic hyperfine interaction between electron and nuclei could be partially averaged out by MAS. The 13C polarization time of DNP was rather long, i.e. 1500 s, and the spin-lattice relaxation time (without microwave irradiation) was about 300 s, which was somewhat shorter than anticipated. Discussions on these experimental results have been made in this report.
Diamond↗
Nucleotide sequence of a cDNA from Onchocerca gibsoni encoding a novel repetitive antigen.
mRNA from uterine microfilariae of the cattle parasite Onchocerca gibsoni was used for the construction of cDNA libraries. A cDNA clone encoding an antigen recognized by serum from human individuals infected with O. volvulus was found to contain five copies of an 87 bp unit. These 87 bp units were present in the genome in high copy number as long tandem arrays. These are the first cDNA sequence data obtained directly from larvae of any Onchocerca species.
Amino Acid Sequence↗
[Effect of phentolamine in combination with pituitrin on the hepatic and systemic hemodynamics].
This experimental study was aimed at the effect of phentolamine used separately or in combination with pituitrin on hepatic and systemic hemodynamics in cirrhotic portal hypertensive dogs. The results showed that either of these drugs used separately could lead to reduction of portal venous pressure. Each of the drugs could also cause by-effect on systemic hemodynamics, or reduce hepatic blood flow. When phentolamine was used in combination with pituitrin no side effect was found in hepatic and systemic hemodynamics. It was suggested that phentolamine used in combination with pituitrin could efficiently decrease portal hypertension and counteract the side-effects. It would be useful in treatment of bleeding from esophageal variceal rupture in cirrhotic patients with portal hypertension.
Animals↗