The Avon Breast Screening Programme.
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Biomedical subjects
Publications and source records attributed to Z Davies.
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An analysis of the urograms of 433 pairs of normal human kidneys performed on patients ranging from birth to 80 years was carried out with the object of relating the mass of the renal parenchyma to the overall size of the kidney at different ages. Statistical analysis of the results showed that there was a highly significant difference in the ratio of mass to overall size in the age periods of 0-5 and 5-10 years, with a significant difference in the third quinquenium. Adult proportions are not reached until the latter half of the second decade of life. Recognition of this aspect of the process of maturation of normal kidneys is essential if radiographic measurement is to be used as a means of estimating kidney damage in the very young.
When protoscoleces of Echinococcus multilocularis were cultured in vitro, under axenic conditions in either monophasic or diphasic media, segmentation was suppressed in most organisms, some 70-80% of which developed into unsegmented, monozoic forms with a complete set of sexually mature male and female genitalia. The most striking feature of monozoic worms was the large lateral swelling produced by the cirrus sac the effect being to produce organisms with an unusual asymmetric shape. Worms which did not become monozoic either (a) underwent some somatic growth, developed two sets of genitalia and became 'pseudo-segmented', i.e. with the inter-proglottid membranes absent or poorly defined, or (b) became vesicular or abnormal. The mechanisms which could be involved in the suppression of somatic growth and the induction of the monozoic condition, are examined in terms of cell lineage. The possible significance of these results in understanding the evolution of the cestodes is discussed.
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