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Z Dizdarević

Publications and source records attributed to Z Dizdarević.

At least 19 recordsLinked to original sources
PubMed2000

[Sarcoidosis activity in a comparison of the tuberculin test and the endoscopic picture in a randomized clinical sample].

The study population consisted of 100 patients with sarcoidosis, selected by method of accidental selection. According to clinical form of sarcoidosis, the sample was divided, in three groups: group of patients with chronic form of sarcoidosis (SHFS)--36 patients, group of patients with acute form of sarcoidosis (SAFS)--46 patients, and group of patients with asymptomatic form of sarcoidosis (SAsFS)--18 patients. The aim of study was to determine whether there were statistically significant differences between the groups of different sarcoidosis clinical forms in diagnosis time in connection with tuberculin reaction, endoscopic picture and index of sarcoidosis activity? Which level of correlation was between index of sarcoidosis activity and tuberculin reaction, respectively endoscopic picture on observed groups of sarcoidosis patients? On the basis of our results we reached the following conclusions: there was significant correlation between magnitude of tuberculin reaction and index of sarcoidosis activity in SAsFS, in SAFS correlation there was no significance and in SHFS there was no correlation. In all of three groups the most frequent was endoscopic picture of enlarged and irregularly arranged capillaries with yellowish plaques on bronchial mucous with average index of activity (6.7).

Adult↗
PubMed1999

[Modern methods in the diagnosis of tuberculosis: PCR--polymerase chain reaction].

The diagnosis of tuberculosis depends on many factors but essentially on the detection of mycobacteria, their identification to the species level, and their susceptibility to major antituberculous drugs. The classic tests (direct examination-Ziehl-Neelsen, conventional culture and antibiotic susceptibility tests) are combined with modern tests (the molecular tests such as genomic amplification /PCR/ direct from clinical samples). By Polymerase Chain Reaction (PCR) over a billion identical bacteria could be multiplied from a single DNA molecule. These modern tests shortened diagnostics duration from several weeks to one or two days. The sensitivity of PCR test was 97% for Z-N positive, 68% for Z-N negative samples while specificity was 99% either for Z-N positive or negative samples.

DNA, Bacterial↗
PubMed1999

[Basic characteristics of the National Tuberculosis Program in Bosnia-Herzegovina].

National TB Programme (NTP) in Bosnia and Herzegovina was approved on 24th May 1994. Following the recommendations of WHO Working Group we revised and supplemented NTP of Bosnia and Herzegovina for 1996 and 1998/99. The objective of the programme was provide practical guidelines on implementation of TB control to all lung diseases and TB specialists over the territory of Bosnia and Herzegovina in accordance with WHO Global Program. TB control through NTP is implemented on the following health care levels: primary health care, General practitioner and family doctor, dispensary of Lung Diseases & TB, Hospitals (Cantonal and Regional), Clinical for Lung Diseases & TB. The effects of this NTP are the following: high sputum smear conversion rates at the end of the initial phase, high cure rates decreased prevalence of chronic excretors of tubercle bacilli, decreased transmission of infection, prevention of drug-resistance. Very good results were achieved in the last three years in TB control with stable incidence through by passive case findings, active finding of contacts, proper and controlled treatment using DOTS strategy as the best TB prevention.

Bosnia and Herzegovina↗
PubMed1999

[An addition to the clinical algorithm for treatment of patients with community-acquired pneumonia in Bosnia-Herzegovina: a multicenter prospective study in Sarajevo].

UNLABELLED: The Patient Pneumonia Outcomes Research Team (PORT) has developed a scoring system that allows the severity of illness to be quantitatively measured. Using an algorithm, the patient can be classified as to risk. The total number of points assigned to the patient increases risk of poor outcome. Patients in risk classes I, II and III have an expected mortality (< 5%) and should be managed as outpatients. Patients with risk class IV and V have mortality rates of 8-29% and should be admitted to the hospital. Patients with risk class V will usually require intensive care. AIM: We started a multicenter prospective study in Sarajevo, to investigate some differences in demographic factors, comorbid diseases, physical examination findings, laboratory findings, the duration, complications and mortality in our population with CAP, than in recommended algorithm. MATERIAL AND METHODS: We recorded the cases of 163 patients (100 male, 63 female) with mean age 58.6 years (17-91). The sample was statistical elaborated with tests of distribution frequency and hi square test. RESULTS: Between demographic factors, as significant, beside age, there was nicotine abuse in 53% (for our CAP population). In comorbid diseases as significant disease beside preexisting cancer (10.5%), chronic liver disease (4%), renal disease (13%), congestive hearth failure (27%), cerebrovascular disease (5%), there was COPD (31%) and diabetes mellitus (9%). Some differences were in physical examination findings, and laboratory findings. The duration of illness, complications and mortality in our CAP population was like in other studies. CONCLUSIONS: This work speaks us that our CAP population has some differences in observed characteristics of scoring system. But, without regard to all this, patients with following characteristics should also be admitted to an intensive-care unit and would be classified as patients with severe pneumonia: hypotensia (systolic blood pressure < 90 mm Hg), impending respiratory failure that may require mechanical ventilation, hypoxaemia (pO2 < 60 mm Hg), hemodynamic instability, heart failure, diabetes mellitus (tip I), COPD, poor dental hygiene (anaerobes--necrotizing pneumonia, empyema, abscess).

Adolescent↗
PubMed1998

[Neurosarcoidosis presenting with transitory neurodeficit and generalized epileptic seizures associated with migraine].

Sarcoidosis is a multi-system disease of unknown etiology with abnormal immune response. Neurosarcoidosis affects 3 to 5% of all patients with sarcoidosis. A case of the patient with neurosarcoidosis, has been presented in this article. He has had leptomeningeal involvement and white matter lesions of the left cerebral hemisphere and clinically, transient neurological deficit, generalised epileptic seizures and migraine headache.

Adult↗
PubMed1997

[Truths and misconceptions about human diseases, medicine and therapy].

The relationship between the truth an misconceptions, which was applied in diagnosis an therapy has been discussed in this work. Concept of the truth and misconceptions has been discussed through the relationship doctor-patient, and the question whether tell the truth about serious, incurable patient's in context of Hippocrates Code and the rules of the religion of Islam.

Humans↗
PubMed1995

[Smoking as a risk factor in the onset of bronchial carcinoma].

With regard to proved fact that smoking plays very important role in appearance of the lung cancer, prevention of the lung cancer goes together with fight against smoking. Since smoking is narcotism, prevention of smoking is the only solution of the problem of smoking, respectively that is the only prevention of bronche-cancer. For those who continue smoking, there is some suggestions, such as: not to smoke the last third of cigarette, do not inhale smoke deeply, to reduce number of consumed cigarette, and to have regularly examinations, i.e. to have X-ray examination of the lung on the six months basis.

Carcinoma, Bronchogenic↗
PubMed1995

[Chemotherapy of bronchial carcinoma].

Antitumorous therapy comprises certain drugs of different origin. Scientific activities in discovering new antitumorous substances and making therapeutic schemes for achieving optimal effects have been presented worldwide for decades. The therapeutic effects are in the most cases very slight. Cured patients are rare, but this sometimes occurs. Partial reducing of tumorous infiltrate and its progression interruption appear more frequently. Therapeutic effectiveness manifests itself in improving of life-time quality. Regard of drug non-indifference and its limited effectiveness, the doctors must wonder about very sensitive question i.e. how much the drug administration will be of benefit or it will diminish this low life-time quality. Experts teams decide usually about drug administration. Early diagnosis is the "imperative" of present possibility appearance of symptoms to definitive treatment. The time from the beginning of the first therapy must be as short as possible if we wouldn't like to loose on therapy effectiveness.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1995

[Evaluation of polychemotherapy of small cell lung carcinoma].

Small cell carcinoma of the lung is a separate clinical and pathological entity with characteristics of early and wide dissemination, and also great sensitivity on chemotherapy and radiotherapy. We evaluated results of therapy of patients with pathohistological verification of small cell carcinoma of the lung with use two polychemotherapy regimes (VCAV and CAP) particular or in combination with radiotherapy. We achieved the best results with application VCAV regime alone (local response 100%, complete response 78.6%, partial response 21.4%) or, in combination with radiotherapy in relation on CAP regime. Our results, when compared to experiences of foreign authors, though we evaluated it on minority series, also demonstrated better results when both regimes of polychemotherapy were used.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

[Evaluation of findings in computerized tomography and other diagnostic methods in pulmonology].

The work has presented a retrospective study of 123 clinica patients, who underwent the chest computerized tomography (CT). With the aim to evaluate the possibilities and importance of CT in diagnosis and therapy of the different pathologic processes, CT results were analysed in relation to other diagnostic methods results. The superiority over conventional radiography (including fluoroscopy and conventional tomography) and importance in evaluation of mediastinal anomalies and pulmonary nodules were confirmed in defining the stages of neoplasms according to TNM system the planning and follow-up of therapy results. CT is not a tissue specific method; the invasive methods are necessary for the definitive histologic diagnosis.

Bronchography↗
PubMed1993

[Analysis of the results of bronchoalveolar lavage (BALF) in patients with pulmonary sarcoidosis].

Bronchoalveolar lavage is a relatively new method in pulmonology. Treatment of broncho-alveolar fluid-washing/BALF/obtained after the procedure of broncho-alveolar lavage/BAL/enables obtaining of samples for investigation of inflammatory and immune cells, so-called alveolar, which, treated by different laboratory procedures, represent the source for different informations at many lung diseases. Analysis of BALF is significant in the differential diagnosis of interstitial lung changes, in the estimate of process activity as well in analysis of therapy with glucocorticosteroids, as well as in the estimate of immune cells state, particularly T abd B lymphocyte subpopulations. We have analysed BALF in 161 patients with lung sarcoidosis with the purpose of analysing the process activity and according to activity of lymphocyte alveolitis in relation to total lymphocyte number in BALF cytogram and by identification of T and B lymphocytes and their subpopulations/CD4, CD8, CD11/as well as by the index CD4/CD8. We have determined the CD4, CD8, CD11 values as well as B lymphocytes by monoclonal antibodies, manufactured by ORTHO-mune/USA/, signed by the manufacturer as OKT4, OKT8, OKT11, OKT22, conjugated by gost antimice IgG antibodies. The working procedure we have done according to instructions of the manufacturer by immunofluorescent technic.

Adolescent↗
PubMed1993

[Characteristics of the pneumonia syndrome in adults during the war in Sarajevo 1992-1993].

We have compared some vital statistics and symptoms as well as clinical findings of the patients hospitalised due to primary non specific lung inflammation in the previous period of aggression at Bosnia and Herzegovina with those in patients hospitalised before the aggression at Bosnia and Herzegovina. The frequency of hospitalisation due to bronchopneumoniae and pleuropneumoniae has been more frequent during the war about three times, while the frequency of treatment from pneumoniae has been the same as before the war. The war population of hospitalised is distinguished in aged persons and persons suffering from chronic diseases, in particular alcoholism, chronic hepatitis and so on. Generally observing, symptoms and physical signs has been more significantly expressed in the war than in the pre-war hospitalised population. The remarkable fact is that clinical findings of values drop of alpha 1 globulins is expressed as well as erythrocytes and the slow increase of leucocytes value in the war in relation to pre-war population of hospitalised from the non specific lung inflammation. The significantly prolonged is the treatment duration, the time of roentgenologic regression of the findings as well as the period of normalisation of haematologic findings with more frequent finding of acute complications (abscess, empyema) in the war than in the pre-war population.

Adult↗
PubMed1989

[Determination of B and T lymphocytes in bronchoalveolar lavage and peripheral blood of patients with active sarcoidosis].

The total number of cells, alveolar lymphocytes as well as T lymphocytes is increased in BAL in patients with active sarcoidosis (acute phase and relapse) with disturbed relation T4-T8 subpopulation. T lymphocytes are significantly decreased in peripheral blood of patients with active sarcoidosis, while B lymphocytes are also decreased but without evident significance in relation to normal values.

Bronchoalveolar Lavage Fluid↗
PubMedDate not supplied

[Percutaneous transthoracic aspiration biopsy guided by computer tomography].

CT-guided percutaneous transthoracic aspiration biopsy presenting one of interventional radiologic procedures, has enabled the sample providing for cytologic analysis. It has been frequently used with the aim of confirmation or elimination of malignant neoplastic process. The main advantages of CT over fluoroscopy are precise needle visualization, documentation of needle tip in the lesion, puncture of small, for fluoroscopy unreachable lesions, as well as the adequate presentation of eventual complications. The authors have analysed, retrospectively, 195 findings of patients, who underwent CT-guided Chiba needle percutaneous transthoracic aspiration biopsy. The finding was cytologically representative in 85.64% of cases, unrepresentative in 14.36%. Out of all complications, pneumothorax (9.74%) and perifocal hematom (9.23%) were most frequent. Contraindications, complications and safety of this very useful method in definitive diagnosing and planning of the adequate therapy have been discussed.

Adolescent↗