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Biomedical subjects

Z E Bavel'skiĭ

Publications and source records attributed to Z E Bavel'skiĭ.

15 recordsLinked to original sources
PubMedDate not supplied

[Antidiabetogenic activity of maninyl].

Experiments were conducted on rabbits. A study was made of the effect of administration of maninyl (glybenclamide) into the stomach in a dose of 10 mg/kg of body weight for 7 days on the blood glucose level, insulin and zinc content in the pancreatic islands, and on the "dithizone" diabetes development. Maninyl administration was accompanied by a significant glycemia reduction. The amount of deposited insulin and zinc determined histochemically was sharply reduced up to complete disappearance from the majority of beta-cells. "Dithizone" diabetes was not reproducible in animals given maninyl preliminarily: the required condition for induction of this affection was formation of zinc dithizonate in beta-cells.

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PubMedDate not supplied

[Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].

The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs. It is concluded that diabetogenic chelating agents are capable of producing irreversible diabetogenic affection in those beta-cells which contain a critical concentration of reactant zinc.

Animals↗
PubMedDate not supplied

[Effect of glibenclamide on the ultrastructure of the islands of Langerhans and their insulin content].

The ultrastructure of the pancreatic islets and insulin content in the beta-cells, revealed by histochemical technique after glybenclamide loading, was investigated in rats. Glybenclamide administration led to the loss in beta-cells of a greater portion of their hormone depot. Ultrastructurally, a significant development in all the organellae of the protein synthesizing apparatus was demonstrated, this testifying to a sharp rise of the hormone production. At the same time insulin released from the cells was accelerated, although no final and complete formation of beta-granules occurred, alpha-insulocytes appeared to be intact.

Animals↗