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Biomedical subjects

Z F Li

Publications and source records attributed to Z F Li.

5 recordsLinked to original sources

Transesophageal low-energy cardioversion in an animal model of life-threatening tachyarrhythmias.

The purpose of this study was to determine the feasibility and efficacy of terminating life-threatening ventricular tachyarrhythmia by low-energy synchronous or asynchronous shocks delivered through a transesophageal catheter that had both an anode and a cathode. Forty-three episodes of ventricular fibrillation or flutter (Vf or VF) were provoked by transesophageal asynchronous random shocks occurring during the vulnerable period of the ventricular cycle in seven dogs and seven pigs that were healthy adults. The 43 episodes of Vf or VF were terminated by the transesophageal technique. The defibrillation energy thresholds were 23.11 +/- 6.28 J (range, 5-30 J). Seven episodes of ventricular tachycardia (VT) with a cycle length of 360 msec or less (330 +/- 27 msec) were provoked by ventricular pacing stimuli during acute myocardial ischemia resulting from delayed resuscitation in two dogs and three pigs. Five of the seven VTs had a duration of 31 seconds or more, and they were all terminated by transesophageal synchronous shocks, the cardioversion thresholds being 1.71 +/- 2.25 J (range, 0.25-5 J). Fourteen episodes of idioventricular tachycardia (IVT) with a cycle length of 400 msec or more (445 +/- 33.5 msec) spontaneously occurred after the use of adrenaline and after defibrillation in four dogs and five pigs. We also succeeded in terminating seven episodes of IVT with a duration of 34 seconds or more by the same means of treating VT, although IVT is not an indication for cardioversion in the clinical setting.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals

[Gastric cancer-associated antigen P42].

The corresponding antigen to monoclonal antibody PCI against gastric cancer cells was demonstrated as a protein sensitive to heating and easily degraded by proteinase. By western blotting, it was shown that the molecular weight of the antigen was 42 KD and the antigen was named P42. P42 could be shed into serum-free culture medium of the target cells and its activity be assayed in sera of the gastric cancer patients. Using inhibition test, the levels of P42-like substance in sera were measured. The results indicated that this level in the gastric cancer patients (26.53 +/- 23.11) was markedly higher than that in patients with benign gastric diseases (4.66 +/- 2.67) and controls (2.57 +/- 2.67). It is suggested that P42, a novel gastric cancer-associated antigen, be useful in the mass screening and supplementary in diagnosing gastric cancer.

Antibodies, Monoclonal

A convolution algorithm for brachytherapy dose computations in heterogeneous geometries.

Currently-available brachytherapy dose computation algorithms ignore heterogeneities such as tissue-air interfaces, shielded gynecological colpostats, and tissue-composition variations in 125I implants despite dose computation errors as large as 40%. To calculate dose in the presence of tissue and applicator heterogeneities, a computer code has been developed that describes scatter dose as a 3-D spatial integral which convolves primary photon fluence with a dose-spread array. The dose-spread array describes the distribution of dose due to multiple scattering about a single primary interaction site and is precomputed by the Monte Carlo method. To correct for heterogeneities traversed by the primary photons, the dose-spread array is renormalized to reflect the density and composition of the element, and the distance to the point of interest is scaled by the path-length of the intervening medium. Convolution calculations for 125I and 137Cs point sources in the presence of finite phantoms, air voids and high-density shields have been compared to the corresponding Monte Carlo calculations. The convolution code absolute and relative dose rate predictions are shown to agree with Monte Carlo calculations within 3%. Direct evaluation of the 3-D spatial convolution integral using 1-D adaptive integration reveals efficiency gains of 20-50 relative to Monte Carlo photon-transport calculations.

Algorithms