[A 3-year echo- and polycardiographic evaluation of left ventricular contractility in disorders of intraventricular conduction].
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Biomedical subjects
Publications and source records attributed to Z Gasior.
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The haemodynamic response to submaximal exercise and atrial pacing in 30 healthy subjects and in 30 patients with coronary artery disease was investigated by M-mode echocardiography. In healthy subjects, the cardiovascular function after atrial pacing was not altered substantially. Exercise, however, caused a marked improvement in haemodynamics, which was due to increased myocardial contractility and diminished afterload. On the other hand, in patients with coronary artery disease, both after exercise and after atrial pacing a significant deterioration of left ventricular function was observed.
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The circulatory system was studied in 43 children (ages 3-18 years, mean 10.6 years; 32 girls, 11 boys) suffering from localized cutaneous forms of scleroderma. The following studies were undertaken: general pediatric examination, cardiologic examination including routine electrocardiogram (ECG), 24-h Holter ECG monitoring, echocardiography plus Doppler study, and a treadmill exercise test. Three children found to have congenital heart malformations were excluded from the study. Children with localized scleroderma were often lighter and shorter than their appropriate controls. The most common ECG abnormality was incomplete right bundle branch block, but other ECG and Holter abnormalities were found as well. Abnormal echocardiographic results were obtained in 16 cases. The abnormalities concerned valvar function (in all heart valves but predominantly in the mitral valve). It was found that the children suffering from scleroderma had different indices than controls for left ventricular mass index, mitral valve function and left ventricular filling. During the exercise test (conducted according to Bruce's protocol) we found no difference between patients and controls.
In 126 patients with clinical ventricular tachycardia and/or fibrillation, ischemic heart disease and repetitive and/or frequent ventricular ectopic beats long-term therapy guided by Holter ecg was assessed. Criteria for efficacy of antiarrhythmic drugs were following: 1) > 75% decrease in ectopic beats, 2) elimination of salvos, 3) > 90% reduction of couples and R/T and 4) reduction of multiformity up to 2 forms. They were fulfilled in 71% of patients (responders). During follow-up 1-49 months, mean 20, rate of sudden death was lower in responders as compared with nonresponders (p < 0.05). However, suppression of ventricular ectopic beats was not predictive for a favorable outcome, because the incidence of arrhythmic events and total cardiac death was similar in the two groups.
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In 45 children with simple obesity (overweight 70 +/- 16%) clinical, electrocardiographic and functional assessment of the cardiovascular system was carried out. The results were compared with those in a control group of 20 healthy children without overweight. Raised arterial blood pressure was found in 14 children (31%) in the studied group. In the control group the blood pressure was normal. Resting electrocardiogram was abnormal in 5 obese (11%) and 2 thin (10%) children. Exercise tolerance was similar in both groups, while the values of systolic pressure and double product were higher in obese children. The value of the tolerated exercise was not correlated with the degree of overweight.
In a group of 45 children with simple obesity (overweight 70 +/- 16%) echocardiographs evaluation of the morphology and function of the left cardiac ventricle was carried out comparing the obtained results with those in a control group (20 children). The mass of the left ventricle was greater in obese children, and the degree of hypertrophy was not correlated with the degree of overweight. The tested parameters of left ventricle systolic activity were within normal limits and were non-significantly lower than in the control group.
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