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Biomedical subjects

Z H Liu

Publications and source records attributed to Z H Liu.

At least 73 records · Page 4Linked to original sources
PubMed1994

[Studies on quality of drinking water and causes of liver cancer in a high-incidence area].

Quality of drinking water was comprehensively studied in Fusui County of Guangxi, a high-incidence area for liver cancer. The results indicated pond water was polluted the most severely, well water the least, and river water intermediately. The chemical indicators for water pollution were levels of ammonia, nitrite, humic acid, suspended substances, chemical oxygen demand, and biological oxygen demand. Quality of drinking water was worse in high incidence area for liver cancer than that in low-incidence one. Mortality of liver cancer correlated positively with the levels of nitrite, humic acid, chemical oxygen demand, and so on. These results provided a basis for further studies on the etiology of liver cancer.

China↗
PubMed1993

Use of fluorescent substrate 4-MUP in the detection of biotin-labeled DNA probes.

To improve the sensitivity of detecting biotin-labeled DNA Probes, a new fluorescent substrate of alkaline phosphatase, 4-methylum belliferylphosphate (4-mup) was studied instead of conventional BCIP-NBT. The result of dot-blot hybridization demonstrates that this new substrate can be used for the colorimetric detection of biotin-labeled probes after hybridization to immobilized nucleic acids. The sensitivity is about one order of magnitude higher than that of BCIP-NBT system, and the time required for color development is very short, only about five min. It is suggested that the Bio-SA-Bio-AP-4-MUP colorimetric detection system can be widely used in gene diagnosis.

Biotin↗
PubMed1993

A communication from the People's Republic of China: management of labyrinthine fistula with cholesteatoma.

Management and results in 43 cases of labyrinthine fistula with cholesteatoma are presented and discussed. The choice of surgical procedure is based on the presence or absence of infection; the size and location of the fistula; condition of the other ear; cochlear function, and condition of the stapes. Unchanged bone conduction has been obtained in 88% of our 43 surgical cases. The planned staged operation has produced good functional results.

Adolescent↗
PubMed1993

Association between HLA antigens and families with psoriasis vulgaris.

This paper typed HLA-A, B, C and DR antigens in patients with psoriasis vulgaris and healthy persons in 12 families. The phenotype frequencies of HLA-A1, B13, B17, Cw4 and Cw6 in the patients were higher than those in the controls. The analysis of haplotype segregation showed that HLA haplotypes in families with more psoriatic cases were marked deviation from random distribution. One or two HLA haplotypes sharing among affected siblings occurred more frequently than expected. The result of Lods score for six families showed that there was a close linkage between the gene of psoriasis vulgaris and HLA antigens. The gene of psoriasis was coincided with the recessive hereditary mode.

Family Health↗
PubMed1992

Antimutagenic effect of eight natural foods on moldy foods in a high liver cancer incidence area.

Ames test procedures were used to test 8 natural food extracts for their antimutagenic activity against the mutagenic activity induced in S. typhimurium strains TA98 and TA100 by aflatoxin B1 (AFB1) or metabolic extracts from A. versicolor or A. ochraceus. The tested substances were extracted repeatedly with acetone. The revertants induced by AFB1, metabolic extracts of A. versicolor or A. ochraceus were significantly decreased when extracts of the 8 natural foods were added to the media. The results showed that these extracts had marked inhibitory effects on the mutagenic activity induced by AFB1 or metabolic extracts of the two molds and also suggested that antimutagenic substances were present in these natural foods. These experiments provide a scientific basis for the study of food substances for the prevention of carcinogenesis. It is considered that these 8 natural food extracts produce marked antimutagenic effects and are practically valuable in the field of chemoprophylaxis of liver cancer in humans.

Aflatoxin B1↗
PubMed1992

CT-guided stereotactic injection of radionuclide for treatment of brain tumors.

The authors report on 40 brain tumor patients treated with CT-guided stereotactic injection of 198Au and 32P. Among the 40 cases were astrocytoma in 23 cases, craniopharyngioma in 9, meningioma in 4, pituitary adenoma in 2, and pinealoma and metastatic carcinoma each in 1 case. The tumors were all located in deep or important areas of the brain which were difficult to deal with by conventional operation. 62 injections of colloidal isotopes were performed, and all were successful. No major adverse effects or complications occurred on follow-up of 6-12 months, 28 patients were improved in their clinical symptoms, and CT scanning showed that the tumor sizes were diminished. The effective rate is 70%.

Adenoma↗
PubMed1992

[Surgical therapy of temporal lobe epilepsy. Clinical report of 30 cases].

Resection of epileptic foci for the treatment of temporal lobe epilepsy was performed in 30 patients (19 right, 11 left). Spike epileptiform wave over the temporal region was found in all patients. All the resected specimen were studied by light and electron microscopy. The operative results showed that no epileptic attack recurred after discharge in 10 patients; seizures were controlled by drugs after 1-2 attacks in 12 patients; rare or occasional attacks in 6 patients; and no effect after operation in 2 patients. The effective rate was 93%, and no death and severe complications occurred.

Adolescent↗
PubMed1992

[Epidermal growth factor and its receptor in the renal tissue of patients with acute renal failure and normal persons].

Epidermal growth factor (EGF) and its receptor (EGF-R) were identified by immunohistochemical method (4 layer PAP) in the renal tissue specimens obtained from 11 normal kidneys and 17 cases of acute renal failure (ARF). The quantitative EGF and EGF-R in the tissue were expressed as positive tubules per mm2. The amount of EGF and EGF-R in renal tissue was markedly increased in cases of ARF than in normal persons. Positive EGF staining was present only in distal tubules, but absent from glomeruli in normal persons. In ARF patients EGF was identified in both distal and proximal tubules. It was also seen in the glomerular mesangial area in 2 cases complicated by mesangial proliferative GN. However, no obvious difference was noted in the distribution of EGF-R between normal and ARF specimens. The amount of EGF in the renal tissue varied with the morphological changes in tubules and the time when the renal biopsy was being taken. The amount of EGF was large in those with a Scr value less than 2.5mg/dl There was a more profound expression of EGF during the recovery from ARF.

Acute Kidney Injury↗
PubMed1992

CT-guided stereotactic injection of radionuclide in treatment of brain tumors.

140 patients with brain tumor were treated by CT-guided stereotactic injections of radionuclides, such as Aurum-198 (198 Au), Phosphorus-32 (32 P) and Yttrium-90 (90Y). Of these patients aged from 3 to 67 years (average 37), 64 were male and 76 female. Astrocytoma was found in 75 patients, craniopharyngioma in 46, metastatic carcinoma in 7, meningioma in 5, germinoma in 4 and pituitary adenoma in 3. The tumors were located in the deep part or functionally critical area of the brain. After 267 times of injection of colloidal isotopes, no major adverse effects or complications occurred. Follow-up for 6 to 48 months showed improvement in symptoms in 104 (74.3%) patients and CT scanning showed the diminished tumors.

Adolescent↗
PubMed1991

[Morphological analysis of 40 polypoid lesions of the gallbladder and their clinical significance].

For the purpose of studying the histological types of gallbladder polyps and their relations to the clinical features, 40 specimens of postoperative polypoid lesions of the gallbladder collected from Changhai Hospital were observed by means of light and electron microscopy. The results demonstrated that the histological types of gallbladder polyps might be divided into: cholesterol polyp, inflammatory polyp, mixed-type polyp and adenomatoid polyp. Cholesterol polyp was the most frequently encountered and the next was inflammatory polyp. A mixed-type polyp is proposed. The adenomatoid polyp might have atypical hyperplasia and potential malignancy. The cholesterol polyp had no relationship with cholesterolosis of the gallbladder.

Adolescent↗
PubMed1991

[CT-guided stereotaxic evacuation of hypertensive intracerebral hematomas].

CT-guided stereotaxic evacuation of hypertensive intracerebral hematomas was performed in 50 patients. Hematoma was found in the basal ganglion in 36 cases in the internal capsule in 23, in external capsule in 6, in thalamus in 7, in subcortex in 6 in cerebellum, in 6 and in brain stem in 2. The volume of these hematomas was less than 10 ml in 2 patients, 20-50 ml in 21, 51-100 ml in 16 and over 100 ml in 11. The liquid hematoma was totally aspirated by stereotaxic technique in 9 patients. Similarly, more than 80% of clots of hematoma was evacuated in 28 patients and about 60-80% of clots was evacuated in 13. Good operative results were obtained in 14 patients (28%). Mild neurological disability was seen in 16 patients (32%) and marked disability in 15 (30%). Five patients (10%) died.

Adult↗
PubMed1991

[Surgical removal of brain stem hematoma].

Of 5 cases of brain stem hematoma, 4 males and 1 female, 4 had hematoma in the pons, and 1 in the midbrain. The diagnosis was confirmed by CT. Two cases had received craniotomy. CT-guided stereotactic evacuation was performed in other 3 cases. All the cases had satisfactory results after operation. None of them died or had any severe complication. Three cases recovered and resumed work, one had mild disability and recovered well in the early time, but died of pneumonia two months later. We stressed that the method of evacuation for the treatment of hematoma is simple and convenient, and the wound is quite small.

Adult↗
PubMed1991

CT-guided stereotactic evacuation of hypertensive intracerebral hematoma.

From January 1986 to June 1989, the CT-guided stereotactic evacuation was performed in 38 cases of hypertensive intracerebral hematoma with satisfactory result. 24 patients were male and 14 female. The age ranged from 37 to 78 years, with an average of 55. 24 cases had their hematoma in internal capsule, 7 in cerebellum, 5 in subcortex, and 2 in brain stem. The interval between the occurrence of hemorrhage and evacuation of hematoma was 24 hours or less in 18 cases, 2-3 days in 14 and 4-7 days in 6. The volume of hematoma was estimated by CT scanning being more than 100 ml in 6 cases whereas much less in 2 cases of the brain stem.

Adult↗
PubMed1991

[Clinical and experimental studies of rheum on preventing progression of chronic renal failure].

Rheum, a well known herb unique in its cathartic effect is now introduced to prevent progression of uremia. A clinical prospective trial was conducted to evaluate its effect in comparison with the Captopril. 30 cases with initial Scr level of 344.8 +/- 114.0 mumol/L were allocated randomly to 3 groups. Rheum E treated group, Captopril treated group and Rheum E + Captopril group. The long term (6-22 mos) follow-up results showed that the progression rate of renal failure, calculated by regression analysis of 1/Scr vs time, was found to be retarded after treatment, being more marked in both Rheum E and Rheum E + Captopril group. Uremic symptoms improved after the treatment with serum albumin level increased. To explore the mechanism of therapeutic effects of Rheum on CRF, a series of experimental studies were performed. Rheum can suppress the proliferation of glomerular mesangial cells in culture. In 5/6 nephrectomized rats, the O2 consumption of remnant kidney was obviously decreased by feeding the animal Rheum E and the hypermetabolic state was ameliorated as well. A group of 5/6 nephrectomized rats were fed with Rheum E for 28 wks. It was found that the level of azotemia of this treated group was lessened remarkably as compared with the controls. The serum albumin and transferrin contents of the treated animals were much higher than the controls while the blood cholesterol and triglycerides decreased unexpectedly. In conclusion, both the in vivo and in vitro studies have proved the effectiveness of Rheum in preventing the progression of CRF.

Adult↗
PubMed1990

A new method for the quantitation of aflatoxin M1 in urine by high performance liquid chromatography and its application to the etiologic study of hepatoma.

A high performance liquid chromatographic (HPLC) method for the analysis of aflatoxin M1 (AFM1) in urine is described. Urine samples were treated with saturated lead acetate and AFM1 was extracted with chloroform. After washing with water to remove impurities the compound was derivatized with trifluoroacetic acid and the AFM1 derivative was analyzed quantitatively by HPLC. The sample pretreatment is simple and more selective. A good line correlation between AFM1 peak height and its concentration was obtained when AFM1 content was in the range of 50-400 pg. The ratio of recovery was 87.42%. Sensitivity is 0.01 ppb. The method is applicable to trace analysis. Results in urine of residents who live in the high/low liver cancer incidence area in Fushui county were the same as that of previous epidemiological investigation.

Aflatoxin B1↗
PubMed1990

Evacuation of hypertensive intracerebral hematoma by a stereotactic technique.

30 patients with a hypertensive intracerebral hematoma were treated by stereotactic evacuation between 1986 and 1988. There were 20 males and 10 females; their ages ranged from 37 to 78 years. The time interval from onset to operation was in 16 patients 24 days and in 14 patients 2-7 days. In 19 patients the hematoma was found in the internal capsule, in 5 in the cerebellum, in 4 in the subcortex, and in 2 in the brain stem. The operation was performed with a Leksell computed tomography guided stereotactic apparatus and a Backlund hematoma evacuator. More than 80% of the hematoma could be aspirated in 20 patients and 60-80% in 10. 29 patients are alive, and 1 patient died.

Adult↗