PubMed Health⌕ Search

Biomedical subjects

Z H Yu

Publications and source records attributed to Z H Yu.

At least 37 records · Page 2Linked to original sources
PubMed1991

[125I]iodomelatonin binding sites in spleens of birds and mammals.

The specific binding of [125I]iodomelatonin to duck spleen membrane preparations was studied in detail. These binding sites were stable, saturable, reversible and of high affinity. Scatchard analysis of the binding revealed a equilibrium binding constant (Kd) of 73.1 +/- 5.4 pM and a total number of binding sites (Bmax) of 3.64 +/- 1.38 fmol/mg protein. Studies on the relative binding capacities of [125I]iodomelatonin to the spleen in different species showed the following order: duck greater than chicken greater than guinea pig greater than pigeon greater than mouse. No binding site was detected in the rat spleen. The presence of [125I]iodomelatonin binding sites in the spleen of birds and mammals suggested a direct action of pineal melatonin on the immune system.

Animals↗
PubMed1991

[Long-term results of conservative surgery plus definitive radiotherapy for stage I, II breast cancer].

A series of 22 patients with Stage I and II breast cancer treated from March 1958 to December 1983 by conservative surgery plus definitive radiotherapy is presented. All patients had tumorectomy or segmental mastectomy with or without axillary dissection followed by radical radiotherapy to the breast, chest wall, axillary, supraclavicular and internal mammary chains. The relapse rate in the breast was 4.55%, axillary node 9% and distant sites 18.18%. The 5-, 10- and 15-year actuarial survival rates were 78.75%, 72.69% and 46.73%, respectively. The data presented show that conservative surgery plus definitive radiotherapy is as effective as the conventional radical mastectomy but with much better cosmetic results.

Adult↗
PubMed1990

[Antifertility actions of gossypol derivatives and analogues].

This paper reports the results of 32 gossypol derivatives and analogues. Among 12 compounds screened by oral administration to male rats, only dipotassium gossypolate (NC030) exhibited an antifertility activity similar to gossypol. Among 24 compounds screened by injecting into pouches of cauda epididymides of rats, 10 exhibited spermicidal activities.

Animals↗
PubMed1990

Effects of deoxycorticosterone acetate on muscle electrolytes, resting potential and mitochondria in rats.

Deoxycorticosterone acetate, injected daily for 5, 10, 20 or 30 days, reduced the serum potassium levels of rats by about 25%, a decrease that was independent of the treatment period employed. Serum sodium concentrations were unchanged with treatment duration. The potassium concentrations in extensor digitorum longus (EDL) and soleus (SOL) muscles were significantly decreased, and those of sodium increased, after treatment. Accompanying these changes of electrolyte concentration, the resting membrane potentials of treated EDL and SOL were hyperpolarized in vivo, and showed depolarization with the decreases of external potassium concentrations in vitro. The mitochondria in the muscles of treated rats were damaged. The degree of damage was more serious in EDL than in SOL and was dependent on the duration of deoxycorticosterone acetate treatment.

Animals↗
PubMed1987

4-bromo-7-hydroxyindan oxime--a new potent spermicidal agent.

The spermicidal effect of eleven chelating agents with a ring structure was evaluated using human spermatozoa. All were potent spermicides in vitro. 4-Bromo-7-hydroxyindan oxime (S-11) was the most potent and its lowest effective concentration for immobilizing sperm within 20 sec was 0.02 mg/ml; its toxicity was also the lowest of the compounds tested with an acute LD50 of 2936 mg/kg. In rabbits, S-11 caused no local irritation to the conjunctiva or quadriceps femoris muscle at a concentration of 0.02 mg/ml. Heart, liver, kidney, spleen, lung and vagina showed no pathological changes when vaginal pessaries containing 1 or 10 mg of S-11 were administered daily, six times a week for 90 days. When vaginal pessaries of 8 or 40 mg S-11 were administered on days 7-15 after mating, no significant abnormality in general appearance, in the viscera or bone development of foetuses were found.

Animals↗
PubMed1987

[Treatment of male breast cancer].

From Mar. 1958 through 1985, 50 male patients with breast cancer were treated in our hospital. The ratio of male and female with primary breast cancer was 1:90 during the same period. All were proven by pathology except one case. Forty seven have been followed for more than 5 years. There were 12 stage I lesions, 19 stage II and 16 stage III. Radical mastectomy was performed in 22 patients, total mastectomy in 11 and lobectomy in 12, supplemented by radiotherapy, chemotherapy, hormonal therapy or their combination. Two were not indicated for surgery and were only given a combination combination therapy without operation. The irradiation after radical mastectomy was to deliver to the regional lymph nodes and for the rest, a dose of 5,000-6,000 cGy/5-6 weeks should be added to the chest wall. The chemotherapy, including Thio-TEPA, 5-fluorouracil, cyclophosphamide and methotrexate etc, in the form of single or multi-drug for 1-3 courses, was given. The overall 5 and 10 year survival rates were 51% and 22.5%. The 5 year survival rates of stage I, II and III patients were 83%, 53% and 25%. The 5 year survivals of radical mastectomy, total mastectomy and lobectomy combined with radiotherapy, chemotherapy and hormonal therapy were 59%, 27% and 67%. In those who failed, 50% developed local recurrence or regional metastasis or both and 60% had extensive dissemination. The results indicate that the combination therapy comprising radical mastectomy and lobectomy has a good prognosis. The authors believe that the male breast cancer is more hormone-dependent than the female breast cancer, orchiectomy plays an important role in the treatment of advanced lesions.

Adenocarcinoma↗
PubMed1986

Radiation therapy of giant cell tumor of bone: analysis of 35 patients.

This paper reports 35 patients treated for giant cell tumor of bone. Ten patients were treated by surgery followed by postoperative irradiation. All 10 were cured; eight have survived for more than 5 years and four for more than 10 years without recurrence. Twenty-five patients were treated by radiation alone. All patients were followed for 2 to 17 years. For those who received more than 3500 rad, the local control rate was 82% (14/17); for those who received more than 4000 rad, the local control rate was 85% (11/13). Thirteen have lived for more than 5 years and nine have lived for more than 10. Our experience reveals that surgery and postoperative radiation produce the best results, and that these results are better than those reported in the literature. The results of radiation alone are comparable to that of surgery. For lesions not amenable to surgery, or those which would become crippling if surgery is attempted, radiation should be used either alone or in combination with conservative surgery. The dose for radiation alone should be 5000 to 6000 rad and for postoperative radiation, 3000 to 4000 rad. Supervoltage X rays (60Co or 8 Mv X ray), but not orthovoltage X rays, are indicated. A single radiation course with higher dose is preferred to multiple courses with lower doses. In 62% (15/24) of patients, pain relief begins before treatment is completed. In 74% (14/19) of patients, the tumor mass will not resolve until the sixth month after radiation.

Adolescent↗
PubMed1986

[Radiation ulcer after radiotherapy of esophageal carcinoma].

17 patients with esophageal ulceration (benign or non-cancerous ulcer) after irradiation for esophageal carcinoma are reported. Nearly half of these 17 patients had been misdiagnosed as cancer recurrence (malignant ulcer) and deprived of further effective treatment. In this series, the cause of misdiagnosis is analysed. The clinical symptoms of benign ulcer and its manifestations on the X-ray films are described. The etiology and differentiation between the benign and malignant ulcer are discussed.

Adult↗
PubMed1986

[Irradiation of recurrent esophageal carcinoma].

81 patients with recurrent esophageal carcinoma after radical radiotherapy were irradiated from Mar. 1958 to Dec. 1973. The results were compared with those of 137 patients with untreated postirradiation recurrences in the same period. Of these 81 patients, 21 failed to complete the second course due to esophageal perforation (8 cases), fatal hemorrhage (4 cases) and deterioration of the general condition (9 cases). The improvement rate of symptoms was 19.75% and that of barium meal was 44.44%. The mean survival of the re-irradiation group was 6.59 +/- 4.66 months in contrast to that of the control group, 4.51 +/- 4.40 months. There was significant difference between these two groups (P less than 0.01). It is shown that the total dose of re-irradiation has no significant effect on the survival. the survival of patients receiving 4,000 rad or less was 5.92 +/- 4.53 months and that of patients receiving more than 4,000 rad was 7.86 +/- 4.72 months (P greater than 0.05). There is no statistical significance in between. We believe that re-irradiation is capable of relieving the symptoms and prolonging survival. It should be selectively used in the patients with recurrent esophageal carcinoma after radical radiotherapy.

Esophageal Neoplasms↗
PubMed1985

Value of computed tomography in staging the primary lesion (T-staging) of nasopharyngeal carcinoma (NPC): an analysis of 54 patients with special reference to the parapharyngeal space.

CT scans of the nasopharynx and the base of skull were performed in 54 patients with histologically proven NPC. The CT findings are compared to those obtained by routine clinical examination. In this series, involvement of the parapharyngeal spaces was found by CT scan in 61% (33/54) of patients, which is impossible to assess by clinical means. Intracranial invasion was demonstrated by CT scan with intravenous contrast enhancement in five patients. CT is more sensitive in showing the erosion of skull base than X ray film. CT scans demonstrated 17% (5/30) of bony invasion in X ray negative patients. Clinical examination showed one involved wall in nine patients; CT scan discovered involvement of two or more walls in five (55%) of these nine. Routine clinical examination discovered extra-nasopharyngeal extensions in 34 locations, whereas CT scans discovered 106, a ratio of 1:3.1. The common sites of extra-nasopharyngeal extension detected by CT scan are: parapharyngeal space, intracranial invasion, sphenoidal sinus, orbit, ethmoidal sinus, maxillary antrum, oropharynx and the nasal cavity. In T-staging of NPC, 55% (6/11) of clinical T2 lesions are up-staged by CT. Thirty-six percent (4/11) of clinical T3 lesions were also up-staged. However, 94% (17/18) of clinical T4 lesions remained unchanged. Only 6% (1/18) of clinical T4 lesions were down-staged.

Bone and Bones↗