The authors analyzed the results of investigation of insulin residual secretion determined by the concentration of C-peptide in response to the stimulation of 1 mg of glucagon. The blood level of the diabetogenic factor (DGF) and activity of the anticoagulative system (ACS) were studied in parallel in patients with insulin-dependent type of diabetes mellitus before and after heparin therapy. The blood DGF disappeared, ACS function was restored, and the patient's body resistance to blood hypercoagulation developed against a background of heparin therapy. A decrease in insulin residual secretion was shown to be related to a duration of diabetes mellitus.

Adolescent↗

PubMedDate not supplied

[Recovery of the anticoagulation system function in patients with insulin-dependent diabetes by neutralization of the activity of diabetogenic factor].

Functions of the anticoagulation system were restored in patients with insulin-dependent diabetes after neutralization of the diabetogenic factor in blood of patients by repeated administration of heparin at low doses. Development of thrombosis was also prevented in these patients.

Adolescent↗

PubMedDate not supplied

[Chlorpropamide-alcohol test in diabetic retinopathy patients].

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Chlorpropamide↗

PubMedDate not supplied

[A case of lipoid reticulosis with endocrine metabolic disturbances].

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Adult↗

PubMedDate not supplied

[Toxic goiter and myocardial infarction].

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Adult↗

PubMedDate not supplied

[Regulatory mechanisms of insulin secretion from beta-cells].

Two-step liberation of labelled calcium from beta-cells was shown to correlate with biphase secretion of insulin. Data on redistribution of calcium in the cells, its binding with calmodulin and participation of glucose metabolites in the insulin secretion are discussed.

Animals↗