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Biomedical subjects

Z I Namazbaeva

Publications and source records attributed to Z I Namazbaeva.

15 recordsLinked to original sources
PubMed2004

[Genetic state of population living on soils polluted with heavy metals].

The study covered heavy metals content of soil at various distances from industrial enterprises. The parameters studied are level of micronuclei in peripheral RBC, frequency and spectrum of chromosomal aberrations in WBC of residents. Finding is increased mutation pace induced by mutagens. Soil pollution with heavy metals appeared a risk factor for genetic instability.

Chromosome Aberrations↗
PubMed1994

[Long-term effect of coal and rock dust on the changes of some biochemical parameters in miners].

The study revealed those changes in connective tissue components and validity of alveolar macrophages in bronchial lavage, which were in correlation with duration and severity of exposure to coal and rock dust. The data proved that roentgenologio changes in the lungs are preceded by changed quantity of viable alveolar cells, higher content of hexauronic acids and hexoses associated with proteins. The stated biochemical tests could be applied to early diagnosis in individuals prone to pneumoconiosis.

Adult↗
PubMed1993

[Structure and biochemical parameters of glycoconjugates of alveolar macrophages exposed to fibrogenic dusts].

Changes in the metabolism of rat alveolar macrophages exposed to quartz and coal dusts were studied by biochemical methods. The intratracheal administration of quartz and coal dusts in 6 hours induced the augmented storage of glycoproteins on the cell surface and the increased lysosomal enzymes (beta-galactosidase, beta-glucuronidase) activities. The quartz dust also induced the decrease of hexauronic acids level. The interaction of macrophage with the fibrogenic dust (quartz) may cause severe disorders in the balance of carbohydrate constituents of glycocalyx, which impairs the vitality of alveolar macrophages.

Animals↗
PubMed1990

[Effect of various environmental factors on health status of children].

The data of the investigation has shown that the high rates of industrial development in Kazakhstan cause multicomponent ambient air contamination. Regression analysis has shown the quantitative relationship between the content of various ingredients in ambient air and certain nosological forms of diseases in children.

Air Pollutants↗
PubMedDate not supplied

[The informational significance of metal bioaccumulation in the hair of preschool children].

Hair and urine metal accumulation was studied in healthy children living in different pollution areas. The levels of biogenic amines, the activity of the enzymes LDH, AP, and cholinesterase were also determined in the exhaled air condensate (EAC) and urine. High accumulation of metals, low EAC levels of biogenic amines, high activity of the urine enzymes were observed in the children residing in high polluted areas. At the same time these changes were less marked in the moderately polluted areas. The revealed changes allow one to select children at risk and to make health-promoting measures.

Air Pollutants↗
PubMedDate not supplied

[The informative value of biochemical and cytochemical markers in laboratory animals during field tests].

Field tests (delivery of animals to differently polluted areas having) were carried out. The criterial significance of biochemical and cytochemical tests of bronchoalveolar lavage (BAL) from the animals was defined. The biochemical tests revealed significant changes in total protein, cholesterol, phospholipids, phospholipase A, histamine, serotonin, and others, which indicates metabolic dysfunction in BAL. The findings suggest that the lysosomal cell membranes are disorganized and the permeability of cell mitochondrial membranes is impaired. Thus, analyzing the findings makes it possible to identify the key links of damages and to define the true significance of environmental factors in realizing the mechanisms of pulmonary preabnormality.

Animals↗
PubMedDate not supplied

[Thyroid functional activity in an experiment upon exposure to manganeferous dust].

The purpose of the study was to examine the effect of polymetallic manganeferous dust on thyroid function in an experiment. Biochemical and cytological studies were used. Seventy-day exposure caused decreased thyroid hormonal levels and thyroid cellular composition changes, which suggest that the dust in question has a cytotoxic effect. A prolonged (3-month) exposure provided evidence that suggests the tension of adaptive mechanisms in the thyroid system under the influence of a toxic factor. Nitric oxide was found to take an active part in the formation of adaptive mechanisms in thyroid tissue.

Adaptation, Biological↗