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Biomedical subjects

Z I Volkova

Publications and source records attributed to Z I Volkova.

At least 19 recordsLinked to original sources
PubMed1994

[The mechanism of the action of laser therapy in rheumatoid arthritis].

48 patients with rheumatoid arthritis (RA) were exposed to He-Ne laser radiation. Due to the course of the above laser therapy the patients displayed reduced levels of E and F2 alpha prostaglandins, a trend to a decrease of lipid peroxidation products, glycosaminoglycans and collagen-peptidase activity. This evidences for suppression of the inflammation and destruction in the connective tissue. Catalase activity in red cells enhanced. The authors point to high efficacy of low-intensity He-Ne laser in moderate rheumatoid inflammation.

Arthritis, Rheumatoid↗
PubMed1992

[The effect of intra-articular emoxipin injections on the course of immune arthritis in rabbits].

Immune arthritis in sensitized rabbits was induced by intraarticular injection of bovine serum albumin. The development of the arthritis was accompanied by an increase in ESR, a rise of the level of serum CRP, caeruloplasmin and CIC. A chemiluminescent response of the whole blood phagocytes to stimulation by barium sulfate crystals, serum beta-glucuronidase and red cell superoxide dismutase activity enhanced, plasma malone dialdehyde content rose, serum SH groups diminished.

Animals↗
PubMed1991

[The total proteolytic and collagenolytic activity in the blood cells of patients with systemic scleroderma].

Collagenolytic (CA) and neutral caseinolytic activity (NCA) was studied in extracts from blood cells (neutrophils, mononuclear cells and platelets) of patients suffering from systemic scleroderma (SSD). 23 persons were examined. Of these, 15 had local skin lesions, 8 diffuse lesions. CA, both specific and per 10(6) cells was found to be dramatically decreased (2-4-fold) in all blood cells, whereas NCA was increased in neutrophils and mononuclear cells; in platelets, it remained within normal. The amount of protein in neutrophils and mononuclear cells was lowered 1.2 and 2-fold respectively. In diffuse skin lesions, the amount of protein in cells was lower than in local lesions. It should be noted that in SSD patients examined, the inflammatory process was unmarked. Therefore, the data on substantial changes in proteolytic activity cannot be related to the inflammatory process. A reverse correlation was established between CA in neutrophils and circulating immune complexes as was a reverse correlation between CA in mononuclear cells and blood antinuclear factor. The data presented indicate that proteinases are an important factor of the pathogenesis in SSD. Apparently, SSD is characterized not only by enhanced synthesis of collagen but also by a dramatic reduction of the activity of enzymes that specifically hydrolyze this group of proteins, which leads to a decrease of collagen catabolism and hence, to the development of fibrosis in tissues.

Adult↗
PubMed1991

[The beta-glucuronidase activity in the blood cells and serum of patients with systemic lupus erythematosus].

Beta-glucuronidase (beta-GU) activity and protein concentration were measured in peripheral blood cells (neutrophils and mononuclear cells) and blood serum of patients with systemic lupus erythematosus (SLE). SLE patients were found to tend towards decrease of beta-GU activity in neutrophils and to an appreciable increase thereof (2-fold) in blood serum. The concentration of protein in both neutrophils and mononuclear cells was within normal. Substantial changes in beta-GU activity were seen in SLE patients with trophic disorders (a significant decrease of the enzyme in neutrophils and a rise in blood serum). These patients also manifested a noticeable reduction of protein concentration in mononuclear cells. The measurement of beta-GU activity in blood cells can be used for the choice of adequate therapy in the course of the treatment of SLE patients.

Blood Donors↗
PubMed1989

[Importance of beta-glucuronidase activity and glycosaminoglycan concentration in synovial fluid in patients with rheumatoid arthritis in estimating local inflammation].

In 30 patients with rheumatoid arthritis, the activity of beta-glucuronidase and the content of sulfated and non-sulfated glycosaminoglycans (GAG) were measured in synovial fluid (SF) and in the cells of SF. It has been established that as the local inflammation increases, the activity of the enzyme and the content of sulfated GAG in SF also rise. This is accompanied by simultaneous reduction of beta-glucuronidase activity in the cells and by the drop of the hyaluronic acid content in SF.

Arthritis, Rheumatoid↗
PubMed1987

[Clinical value of determining beta-glucuronidase and glycosaminoglycans in blood cells and biological fluids in patients with rheumatoid arthritis].

Patients with proved rheumatoid arthritis (RA) demonstrated changes in the activity of beta-glucuronidase and the concentration of glycosaminoglycans (GAG) in the blood formed elements and biological fluids showing correlation with peculiarities of the RA course. The content of beta-glucuronidase and GAG in biological fluids well reflected the activity of an inflammatory process. Significant differences in the level of beta-glucuronidase and GAG in blood cells of patients with the articular type of RA and systemic manifestations of disease were revealed.

Adolescent↗
PubMed1980

[Isolation and characteristics of the DNA of donor and systemic lupus erythematosus patient blood plasma].

DNA from blood plasma of healthy donors and patients with systemic lupus erythematosus (SLE) was isolated by various techniques. Adsorption chromatography of hydroxyapatite with subsequent deproteinization has shown that DNA of blood plasma from both healthy donors and patients with SLE is associated with serum protein and is low-molecular. This combination (DNA--protein) is resistant to the action of nuclease but susceptible to pronase. DNA that circulates in blood of SLE patients in conjunction with immunoglobulins is high-molecular as compared to DNA associated with other serum proteins.

Adsorption↗