Biomedical subjects

Z Jezková

Publications and source records attributed to Z Jezková.

At least 19 recordsLinked to original sources

PubMed1993

[Chorioamnionitis and perinatal infection in neonates].

The authors investigated the relationship between histologically confirmed chorioamnionitis and the development of adnatal infection in the neonate. From a total of 4,144 deliveries during the investigation period-January 1, 1988 to December 31, 1989-252 placentas of neonates after pathological deliveries were examined. Chorioamnionitis was recorded in 28.6%, i.e. in 72 placentas inflammatory changes were found. Adnatal infections of neonates with chorioamnionitis were detected in 20.8%, i.e. 15 neonates. On the other hand, in the group of neonates where no inflammatory changes of the placenta were present adnatal infections were recorded in 8 infants, i.e. 4.4% (p = 0.00004). The mortality rate from adnatal infections in the group of neonates with chorioamnionitis was 4.16%. In the group of neonates without chorioamnionitis no death due to adnatal infection was recorded (p = 0.00000). Chorioamnionitis is thus associated with a significantly higher incidence of clinical adnatal infection in neonates and mortality due to this infection.

Chorioamnionitis↗

PubMed1991

The direct early diagnosis of cystic fibrosis by the detection of the delta F508 CFTR gene mutation in a prematurely delivered boy.

The suspicion of prenatal meconium ileus syndrome was raised in a pregnancy in a family with no history of cystic fibrosis because of significantly higher maternal serum alpha-fetoprotein in the 16th and 19th week of gestation, dispersed areas with increased echogenity in the fetal abdomen, slight fetal ascites in the 24th-25th weeks of gestation, decreased amniotic fluid gamma-glutamyltranspeptidase (GGT) activity and alpha-fetoprotein level in the 25th-26th weeks, and normal 46,XY karotype of the fetus. The detection of a homozygous deltaF508 cystic fibrosis transmembrane regulator (CFTR) gene mutation, by means of PCR from a small amount of white blood cells and urine sediment cells, substantiated the diagnosis of cystic fibrosis in a prematurely delivered boy in the 28th week of gestation. The repeated sweat test was unsuccessful. The autopsy examination confirmed the diagnosis of cystic fibrosis. Fetal meconium ileus syndrome was complicated by peritonitis and by formation of a meconium pseudocyst. Direct PCR typing improves postnatal diagnostic possibilities in the early neonatal period in prematurely delivered babies when the sweat test is difficult to perform.

Chromosome Deletion↗

PubMed1987