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Biomedical subjects

Z Kazibutowska

Publications and source records attributed to Z Kazibutowska.

At least 19 recordsLinked to original sources

[The value of electroneurography in recognition of peripheral ischaemic polyneuropathy in patients suffering from critical leg ischaemia].

Peripheral arteries disorders cause not only leg ischaemia, but also peripheral polyneuropathy. Polyneuropathy increases ischaemic pain. The aim of this study was to estimate how many patients suffering from critical leg ischaemia have symptoms of peripheral polyneuropathy. 40 patients were investigated: 37 men and 3 women; mean age was 57 years. All patients underwent electroneurographic examination. It consisted of measurements of motor conduction in tibial and peroneal nerves, wave F, sensory conduction in sural nerve. Polyneuropathy was observed in 95% of patients. The frequency of polyneuropathy was also significantly enlarged in leg with non critical ischaemia. We did not observe the greater risk of polyneuropathy in diabetic patients. The work is an introduction to the following clinical studies.

Adult↗

Visually evoked potentials and simple reaction times to visual stimuli in chronic disulphide intoxication.

The relationship between parameters of visually evoked potentials (VEPs) and the results of a psychological test assessing the speed of motor reaction to visual stimuli was examined in 21 patients with chronic carbon disulphide intoxication. Correlations obtained suggest cerebral disfunction of the visual pathway and diminished ability to transform visual information to motor reaction at the level of the cortical association centre.

Adult↗

Multimodality evoked potentials in occupational exposure to metallic mercury vapour.

Central nervous system dysfunction among workers exposed to metallic mercury was studied by measuring somatosensory evoked potentials (SSEPs) and visual evoked potentials (VEPs). The examinations were conducted in 28 workers suspected of chronic mercury intoxication. They were exposed to Hg for a period ranging from 4-34 years (mean 22.1) in an acetic aldehyde and chlorine manufacturing plant. The increase of amplitude of N20 SSEP (13 cases) and elongation of its latency were frequent abnormalities in the examined group. The latency of N20 was significantly longer in the exposed group in comparison with the control one, the amplitude of N20 was also significantly higher. Significantly prolonged latency of P100 VEP was found in the group exposed to Hg. These findings suggest the possibility of an adverse effect due to Hg on the central part of the somatosensory and visual pathway.

Adult↗

[Conduction in the motor fibers of the ulnar nerve in cut-glass workers].

The authors have estimated the motor conduction velocity of ulnar nerve motor fibres in 39 glass-cutters suspected to neuropathy originating from work performance. The conduction has been checked in two segments; wrist-elbow and below-above elbow (peripheral) and sulcus segments). Twenty-nine workers exhibited reduced conduction; in the sulcus segment--13-fold, in the peripheral segment--4-fold, and in both segments--12-fold. The nerve impairment was greater on the left side, especially in the sulcus segment. After 4 to 24 months another investigation was performed in 22 persons--10 carrying on the work and 12-who had abandoned it. The former group exhibited the impairment, whereas the latter--both improvement and progression. The authors suggest that an appropriate evaluation of the ulnar nerve lesion in glass-cutters but also people representing other professions causing the nerve pressure calls for an investigation of the conduction in the sulcus and peripheral segments.

Adult↗

[Fertility in the population of women with epilepsy].

Retrospective inquiry investigations of 263 women with epilepsy at the age above 15 years demonstrated that the reproductive functions in these women were twice lower than in the general population of this region. The number of unmarried was 7% above that in the population, 25% of married epileptic women had no children, and most married women controlled the birth rate resorting frequently to artificial abortions. The index of perinatal mortality of the newborns, dead fetuses and early deaths) was over three times higher than in the population: 88.2 and 25.6 respctively. The risk of spontaneous abortion was 11.3%, the risk of stillbirth 3.9%, the risk of early neonatal death 4.6%. The risk of spontaneous abortion and early neonatal death was higher in the group of women taking anticonvulsants during pregnancy.

Abortion, Spontaneous↗

[2 cases of ischemic cerebral stroke in a young man with hyperlipidemia type IV].

In a young man at the age of 29 and 35 years without risk factors for atherosclerosis and, consequently, cerebrovascular disease two severe strokes of atypical clinical pattern developed leading to considerable impairment of psychomotor fitness. Diagnostic tests and study of family members demonstrated familial hyperlipidaemia type IV.

Adult↗

[Results of prospective 24-hour EEG studies of patients after cranio-cerebral injuries].

In 26 patients 24-hour cassette EEG recording and routine EEG records were taken between 6 and 35 days and again between 6 and 12 months after craniocerebral trauma. Neurological examination and CT of the head demonstrated cerebral concussion in 11 cases and brain contusion in 15 cases. Early after trauma routine EEG was abnormal in 5 cases (19.2%) exclusively in those with brain contusion, and 24-hour EEG recording was abnormal in 16 cases (61.5%), including 7 with cerebral concussion and 9 with brain contusion. In the second half year after trauma 24-hour EEG was normal in 5 cases (19.2%) which had previously abnormal records, and abnormal EEG changes appeared in 6 cases (23.1%) with previously normal findings. Seizure activity was found in the first weeks after trauma in 9 (34.6%) 24-hour recordings. In the second half year after trauma seizure activity was no longer present in 2 cases, but appeared in 6 other cases. Thus 24-hour recording between 6 and 12 months after trauma demonstrated seizure activity in 50% of all patients. In 2 of them epileptic fits developed. The study shows that repeated 24-hour EEG recording after craniocerebral trauma may be important in early detection of patients who are at risk of epilepsy development.

Adolescent↗

[24-hour monitoring of bioelectric activity of the brain in patients after cranial injuries].

In patients after craniocerebral trauma 24-hour EEG and routine EEG records were obtained. 44 cases were studied between 6 and 38 days after trauma and 45 cases were examined between 6 and 12 months after trauma. The diagnosis of brain commotion in early phase based on neurological examination and computed tomography was made in 22 cases, while in 22 cases late posttraumatic phase was diagnosed. Brain contusion in early and late phase was diagnosed in 22 and 23 cases, respectively. Early after craniocerebral trauma the study demonstrated changes in routine EEG in 8 cases (18.1%), while 24-hour EEG demonstrated them in 26 cases (59.0%), that is three times more as frequently. Changes in 24-hour EEG were found nearly twice as frequently than in routine EEG 6-12 months after trauma (51.0% and 28.9% respectively). In patients with brain commotion in the first week after trauma only 24-hours EEG revealed changes. Late after trauma 24-hour EEG could demonstrate seizure activity more frequently than routine EEG.

Action Potentials↗

[Multimodal evoked potentials in the early period after cranio-cerebral trauma].

In 83 patients aged 17-68 years somatosensory evoked potentials by median nerve stimulation, and visual and auditory evoked potentials were studied 5-28 days after craniocerebral trauma. Brain concussion was diagnoses in 43 cases on the basis of neurological examination, CT and duration of unconsciousness. In the remaining 40 cases brain contusion was diagnosed. In SSEP the latency was calculated of waves N9, N13, P16, N20, P22, N35 and P40: in the visual evoked potentials the latency of the P100 component, and in auditory evoked potential the latency of waves I, III and V, and interpeak latency I-III, III-V and I-V SSEP changes were found in 39% of cases of brain concussion and 52.9% of brain contusion cases. The abnormalities in both groups involved mainly the component of latency and deviation P100 of visual evoked potential P40 and N35. Prolongation of the latency of P100 of the visual evoked potential was recorded in 20% of patients with brain concussion and 16.7% with brain contusion. Auditory evoked potentials were abnormal in 10.3% of brain concussion and 26.5% of brain contusion cases. In 64 cases all three types of evoked potentials were studied and pathological changes in at least one of these types were found in 56.4% of brain concussion and 72% of brain contusion cases. The results show that as least in a part of cases diagnosed as brain concussion according to generally accepted criteria, central nervous system injury is present.

Adolescent↗

[Prospective studies of multimodal evoked potentials in patients after cranio-cerebral injury].

In 42 patients aged 18-68 years somatosensory, visual and brainstem auditory evoked potentials were studied in the first month after trauma and after 6-8 months after craniocerebral trauma for evaluation of their diagnostic importance in less severe craniocerebral trauma. On the basis of the results of neurological examination, CT of the head, and duration of unconsciousness in 22 cases brain concussion and in 20 cases brain contusion was diagnosed. In patients after brain concussion the frequency of early and late abnormalities after head trauma was as follows: for SSEP 36.4% and 27.3% respectively, for visual evoked potentials 21.1% and 5.3%, for auditory potentials 9.5% and 4.8%. In cases of brain contusion abnormalities were found in the 1st month and 6-8 months after trauma in SSEP in 60% and 20% respectively, in visual EP in 11.1% and 22.2%, and in auditory EP in 30% and 40%. In the group of concussion the greatest and most persistent changes developed in the later components od SSEP. Among certain patients with brain contusion deterioration of the results of visual and auditory evoked potentials were noted late after trauma.

Adolescent↗