Biomedical subjects

Z Killinger

Publications and source records attributed to Z Killinger.

7 recordsLinked to original sources

PubMed1999

[Bone turnover and bone density in type 1 diabetics in the initial stages of diabetic nephropathy].

OBJECTIVE: To compare the bone turnover and bone mineral density in type 1 diabetic patients with normoalbuminuria and type 1 diabetic patients with diabetic nephropathy with microalbuminuria or mild proteinuria. METHODS: We studied 18 type 1 diabetic patients (Group A) with normoalbuminuria (UAE < 10 micrograms/min) and 8 type 1 diabetic patients (Group B) with UAE 100-1000 micrograms/min and serum creatinine below 150 mumol/l. Markers of bone formation (bone alkaline phosphatase--ALP-B, serum osteocalcin) and bone resorption (serum tartrate-resistant acid phosphatase--ACP-TR, urinary hydroxyproline) were determined. Bone mineral density (BMD) was measured at lumbar spine and right femoral neck. RESULTS: Serum ALP-B was higher in group B [median (95% CI), 518 (405-1070) nkat/l] compared with group A [380 (355-510) nkat/l] (p < 0.05). Urinary hydroxyproline excretion was higher in group B [U-Hxp/U-creat 46.7 (22.9-80) mumol/mmol] compared with group A [18.3 (8.9-22.7) mumol/mmol] (p < 0.001). No difference was found in serum osteocalcin and ACP-TR and in BMD at L2-L4 and femoral neck. CONCLUSIONS: We conclude that bone turnover was increased in type 1 diabetic patients with incipient stage of diabetic nephropathy but there was no difference in BMD as compared with type 1 diabetic patients without nephropathy. This finding might indicate that biochemical markers unlike densitometry reflect initial changes in bone metabolism in preclinical diabetic nephropathy earlier. (Tab. 2, Ref. 17.)

Adult↗

PubMed1998

[Bone changes in gastrointestinal diseases].

BACKGROUND: Gastrointestinal (GIT) diseases are a common cause of metabolic bone changes. The aim of the study was to indicate GIT diseases (lactose intolerance, non-lactose intolerance, Crohn's disease, ulcerative colitis, pancreatic insufficiency, states after gastric resection, chronic diseases of the liver, and coeliac disease) by means of literature data and the authors' own results coinciding with the detected low bone density and thus increased risk of fracture. Bone changes coinciding with GIT diseases are frequent and are commonly asymptomatic for a long period. CONCLUSION: In coincidence with GIT diseases the authors indicate the necessity of being aware of the risk of bone changes development and to investigate them actively. An early diagnosis aids to introduce preventive and therapeutical measures and to halt or at least slow down the origin of bone changes. (Ref. 21.)

Bone Diseases, Metabolic↗

PubMed1997

[Bone changes in ulcerative colitis].

One of the complications of ulcerative colitis with frequent relapses is mineral deficiency (potassium, calcium, magnesium and phosphorus). The objective of the present work is to examine the bone density and laboratory parameters of bone metabolism in 25 patients with a medium severe and severe form of ulcerative colitis. In patients with ulcerative colitis a significantly reduced bone density was found in the era of neck of the femur (p < 0.05), a a non-significantly reduction of the bone density in the era of the lumbar vertebrae and an elevated level of osteocalcin (p < 0.05). These findings indicate a higher prevalence of bone changes in patients with ulcerative colitis. Early detection of bone changes makes adequate prevention and treatment of bone complications possible.

Adult↗

PubMed1995

[Safety of hormone replacement therapy in menopause and its favorable effect on the lipid spectrum].

The authors pay attention to changes of the serum lipid spectrum and blood sugar level during hormonal substitution treatment of menopausal women. The observation pertains to 70 women (mean age 50 years, 36 women after hysterectomy, mean duration of the menopause 4.5-5.0 years). The lipid spectrum and blood sugar level were assessed by enzyme methods from venous blood collected in the morning on fasting before administration of treatment (a combination of oestrogen and gestagen), on average after 8 months on these drugs. With regard to total cholesterol and HDL-cholesterol before treatment the women were, consistent with recommendations of the European Society for Atherosclerosis divided into four groups: hypercholesterolaemic group (5.2-7.8 mmol/l) 47 women; hypercholesterolaemic group with a reduced HDL-cholesterol (less than 1.1 mmol/l) 5 women; a very high cholesterol group (more than 7.8 mmol/l) one woman only; and women with a normal lipid profile (total cholesterol less than 5.2 mmol/l), 17 women. The authors recorded in the whole group a significant drop of total cholesterol (-0.30 mmol/l), VLDL-cholesterol (-0.08 mmol/l) and triacylglycerols (-0.27 mmol/l) and a significant rise of HDL-cholesterol (+0.13 mmol/l). The blood sugar level did not change. There was an insignificant drop of LDL-cholesterol. Hepatic serum enzymes did not change during this treatment. The most marked changes (a drop of LDL-cholesterol by 0.49 mmol/l and rise of HDL-cholesterol by 0.29 mmol/l) were recorded in the group with the highest risk, i.e. group 2. The total drop of triacylglycerols was striking. The body weight and dietary habits did not change during the mentioned 8-month period. The authors consider hormonal replacement therapy indicated. They emphasize its favourable effect on the lipid spectrum of women which is one of the mechanisms of cardiovascular oestrogen protection.

Adult↗

PubMed1994

[Congenital atransferrinemia].

Congenital atransferrinemia was first diagnosed at the age of 11 months in a now 27-year-old woman. Until she was aged 14 years treatment with human transferrin was irregular and, as it turned out, inadequate. But since then she has regularly received human transferrin (1 g monthly) and deferoxamine (500 mg twice weekly). Despite this she developed haemosiderosis affecting heart, liver, hypophysis, thyroid and the locomotor apparatus. This case report demonstrates the need of early diagnosis and treatment of congenital atransferrinemia to prevent the mentioned complications.

Adult↗

PubMed1993

[Hypereosinophilia syndrome].

The authors of the submitted paper describe the diagnosis, course and treatment of hypereosinophilic syndrome in a 36-year-old female patient with marked affection of the right ventricle: endomyocardial fibrosis with parietal thrombi obliterating the cavity of the right ventricle. The clinical picture was dominated by rapid progression of severe cardiac decompensation with a fatal outcome.

Adult↗

PubMed1993

[Time delay in acute myocardial infarct].

The authors present their experience concerning the time-delay in 357 patients with acute myocardial infarction admitted to the coronary unit over the years 1988-1991. This time indicator was evaluated by using two approaches, i.e. the global time-delay (the time between the onset of the patient's complaints and his/her admission to the coronary unit) and patient's time-delay (the time between the onset of the patient's complaints and his/her decision to notify the health care service). Arbitrary criteria were set up: 10 hours for the former and 5 hours for the latter parameter. The established criteria were met by 40% of the patients. Only 24% of the patients presented at the coronary unit within 6 hours, and these could receive thrombolytic treatment. The decision time (patient's time-delay) amounted that the education level of our population has to be enhanced so as to increase the number of patients with acute myocardial infarction presenting at the coronary unit at an early stage. (Tab. 1, Ref. 9.)

Coronary Care Units↗