Biomedical subjects

Z Kinoshita

Publications and source records attributed to Z Kinoshita.

10 recordsLinked to original sources

PubMed1994

Effects of the anabolic steroid nandrolone phenylpropionate on craniofacial growth in rats.

Primary testosterone and its derivatives are anabolic steroids used in the treatment of osteoporosis and Turner syndrome. They also enhance fast-twitch muscle weight in female rats. The present study examines the effect of an anabolic steroid on craniofacial growth and development in rats. Five-week-old female Sprague-Dawley rats (125) were divided into experimental and control groups. The experimental group was injected subcutaneously with 1 mg nandrolone phenylpropionate in the interscapular region on alternate days, whereas those in the control group were injected with a vehicle, arachis oil. Rats were sacrificed at 60 and 120 days of age. Cephalometric analysis of soft X-ray cephalograms showed that chronic administration of the anabolic steroid, nandrolone phenylpropionate, resulted in: (1) about a 20% increase in body weight, (2) an increase in total skull length, (3) elongation of the maxillary and mandibular incisors, (4) an increase in the depth of the antegonial notch, and (5) downward-forward growth of the viscerocranium against the neurocranium. These results suggest that nandrolone phenylpropionate may accelerate craniofacial growth and/or induce high functional activity of the masticatory muscles in female rats.

Anabolic Agents↗

PubMed1993

A study of the growth changes in facial configuration.

In order to explore the growth changes in facial configuration, 160 subjects (80 young adults and 80 children aged 11-12) with normal occlusion were selected for roentgenocephalometric analysis. The present study led to the following conclusions: (a) The ratios of anterior upper to anterior total facial heights, anterior lower to anterior total facial heights, and anterior upper to anterior lower facial heights in both sexes stayed constant around 45, 55, and 81 per cent, respectively. (b) The change in the ratio of the posterior total to anterior total facial heights was mainly due to the greater potentiality of the posterior part of the lower face. (c) The increases of the lower anterior and posterior dental heights were larger than that of the upper anterior and posterior dental heights, respectively. The increases of the upper and lower posterior dental heights were larger than that of the upper and lower anterior dental heights, respectively. (d) On average, the mandibular plane and the occlusal plane tended to rotate forwards with age while the cant of the sella-nasion plane, the Frankfort horizontal plane, and the palatal plane remained fairly unchanged. (e) The saddle angle, the articular angle, and the FNA angle remained relatively stable with age, while the gonial angle and the FNB angle seemed to be age-related. The decrease in the size of the gonial angle might contribute mainly to the flattening tendency of the mandibular growth coincident with general growth. (f) Both the inclination of upper incisor to palatal plane and lower incisor to mandibular plane remained reasonably constant throughout maturation.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1992

Craniofacial pattern of Class III deciduous dentition.

The purpose of this study was to investigate the morphological characteristics of the cranio-dento-facial complex of children with deciduous dentition and Class III malocclusion. Forty Chinese children in Taiwan with normal occlusion and 40 with Class III malocclusion in deciduous dentition were selected for cephalometric analysis. Mandibular length was significantly greater and the mandible was situated farther forward in the Class III group. The maxilla was also slightly backward in this group, perhaps in association with the shorter maxillary length. The mandibular incisors were tipped lingually to compensate for the intermaxillary skeletal dysplasia and the maxillary incisors were tipped lingually by the retroinclined mandibular incisors.

Cephalometry↗

PubMed1989

Application of video surgery to orthodontic diagnosis.

The purpose of this project was to develop a practical methodology for predicting the visual facial changes resulting from the movement of anterior teeth. The armamentarium includes an 8-bit audiovisual computer, a video camera, a digitizer, and a cephalogram of the patient. The system outputs the patient's profile on a personal computer video display. The image is superimposed on the soft tissue line of a digitized cephalogram plot on the same display. The video profile image is transformed from analog to digital signals. The profile image digitized by the computer is modified according to average ratios of soft tissue to hard tissue changes induced by modifications to the hard tissues. The program incorporates the spline function to smooth the profile image.

Audiovisual Aids↗

PubMed1989

[Case of TMJ arthrosis occurred during orthodontic treatment of patient with unilateral cleft lip and alveolus].

A female patient of fifteen years old with anterior crossbite was treated orthodontically with multi-bracket system. During the orthodontic treatment clicking and trismus were appeared. According to the consultation, it was found that the TMJ disorder was in the stage of the closed lock. The patient was treated with the manipulation technique and the anterior repositioning appliance was applied. After three months, the pain and trismus were relieved. The maxillary arch was expanded laterally to eliminate the premature contact caused by the maxillary and mandibular canines. Consequently, intercanine width of the maxillary arch was increased and the cuspal interference was disappeared. After three month observation, it seemed that the symptoms of TMJ were recovered. Then, orthodontic appliances were removed and the retainers were set. It was concluded that the examination of TMJ condition may be necessary for orthodontic patients with anterior crossbites.

Adolescent↗

PubMed1987