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Biomedical subjects

Z L Cao

Publications and source records attributed to Z L Cao.

6 recordsLinked to original sources
PubMed1991

[The effect of Bulbus allii on precancerous lesions of the esophagus due to N-methyl-N-amylnitrosamine in rats].

In so much as precancerous lesions of the esophagus are a stage that must pass in the course of formation of carcinoma of the esophagus, inhibiting its occurrence is an important measure in the prevention of esophageal. The test was carried out in 84 Wistar rats of both sexes randomly divided into 2 groups, one group fed with 50% aqueous extract of Bulbus allii and the other as control. After 105th day of experiment, results showed that Bulbus allii inhibited significantly precancerous lesions of the esophagus due to N-methyl-N-amyl-nitrosamine (P less than 0.05) increases of the splenic index (P less than 0.001) in rate and the percentage of peripheral T-lymphocyte (P less than 0.01) in rats. The results suggested that Bulbus allii had a preventive action against carcinoma of the esophagus, which could be attributed to increasing the immunity.

Animals↗
PubMed1989

[Relationship between HBcAg in the liver and mechanisms of chronic type B hepatitis HBVM in serum].

We detected the presence and distribution of HBcAg in the liver by immunohistochemistry (ABC method) and the presence of HBV-DNA in serum (spot hybridization) and anti-HBe in serum (ELISA) from 59 cases of hepatitis B hospitalized in our hospital, including 47 cases of CAH, 5 cases of CPH, and 7 cases of subacute fulminant hepatitis. 1. HBcAg in the liver was detected in 25 out of 47 cases (53%) of CAH, in 2 out of 5 cases of CPH and in 4 out of 7 cases of subacute fulminant hepatitis. The total percentage was 53% (31/59). 2. There was no positive correlation between HBV replication activity and liver disease activity (P greater than 0.05). Our results did not support the hypothesis that suggests a direct cytopathic effect of HBV. Oppositely, the fact was that the presence, the amount and the patterns of HBcAg in the liver, and the presence of HBV-DNA in serum were predominant in mild CAH compared with those in severe CAH, predominant in CAH without cirrhosis compared with those in CAH with cirrhosis. There was a tendency of inverse correlation between HBV replication activity and liver disease activity. The results above were in line with the concept that HBcAg expressed on the surface of infected hepatocytes may be relevant target for T lymphocyte cytotoxicity. The results have suggested that an immune response to HBV is present, leading to the destruction of most infected cells. 3. There was a positive correlation between HBV-DNA in serum and HBcAg in the liver (P less than 0.005), indicating that HBV-DNA in serum can represent HBV replication.(ABSTRACT TRUNCATED AT 250 WORDS)

DNA, Viral↗
PubMed1989

[Correlation between hepatic microcirculation ultrastructural changes and hepatic dysfunction in chronic hepatitis B].

The author observed the ultrastructural changes of hepatic microcirculation and the function of the liver in 41 cases with chronic hepatitis B confirmed histologically. The main ultrastructural changes found in patients were swelling of the endothelium of hepatic sinusoids, hyperplasia of Kupffer cells and decrease of fenestrae in the endothelium. Proliferation of monocytes and fat-storing cells was also found in the lumina of hepatic sinusoids and space of hepatocytes and perisinusoid. The basement membrane in hepatic sinusoids and the base of hepatocytes were formed in the patients with marked pathologic changes of the liver, especially in CAH with cirrhosis. The observations also showed that whatever extent of hepatic microcirculation changes, all of them had more or less elevation of SGPT and ZnT or TT. As soon as hepatic function was impaired slightly, there occurred hepatic dysmicrocirculation. But in the cases of severe ultrastructural hepatic dysmicrocirculation serum gamma globulin elevation values and A/G ratio exchanges were much higher than those in the cases of slight changes. There was some significance on the judgment of sick condition, slight or severe. Values of the elevation of serum gamma globulin and A/G ratio exchanges were much more obvious than SGPT, ZnT and TT changes. These findings suggest that the extents of pathological changes and dysfunction of the liver in chronic viral hepatitis B are correlated to the extent of hepatic microcirculation impairment. So in the treatment of chronic hepatitis early administration of medicine to improve the liver microcirculation should be considered.

Adolescent↗