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Biomedical subjects

Z Landau

Publications and source records attributed to Z Landau.

At least 19 recordsLinked to original sources
PubMed2006

Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells.

Chronic surplus of dietary consumption, typical to obesity, results in overflow of fat to non-adipose tissues. Intracellular accumulation of fat in non-adipose tissues is associated with cellular dysfunction and cell death and ultimately contributes to the pathogenesis of chronic diseases. The influence of fat overflow on the exocrine pancreas is not known. The purpose of this research was to study the lipotoxic and lipoapoptotic effect of prolonged (72 h) long chain saturated palmitic fatty acid (0.1 mM) on the survival of exocrine pancreas AR42J cells. We demonstrate that chronic exposure of AR42J cells to palmitic acid results in significant increase in triglycerides accumulation (up to 25% of cells area), compared to untreated cultures. Lipid accumulation prompted a typical apoptotic process, demonstrated by both DNA fragmentation and condensed chromatin appearance (DAPI staining). Quantitative real-time PCR studies demonstrated that prolonged palmitic acid supplementation induced down-regulation of the anti-apoptotic Bcl2 mRNA levels (22%) and up-regulation of the pro-apoptotic Bax mRNA levels (300%), leading to disruption of the pro/anti apoptotic balance (Bax/Bcl2=3). No major change was detected in iNOS mRNA expression. In conclusion, prolonged exposure to saturated palmitic acid induces lipoapoptosis in exocrine pancreatic AR42J cells, through disturbance of the Bax/Bcl-2 balance.

Animals↗
PubMed1999

Chronic brucellosis in workers in a meat-packing plant.

We report an outbreak of brucellosis among 9 patients in a meat-packing plant. All patients developed chronic brucellosis characterized by severe chronic musculoskeletal pains, diffuse arthralgia, myalgia and recurrent bouts of fever, which we suggest may be related to a delay in antibiotic treatment. All the patients had a prolonged recovery requiring rehabilitation therapy.

Adult↗
PubMed1999

Mediterranean spotted fever in pregnancy.

Mediterranean spotted fever has rarely been reported in pregnancy. We report a case occurring in a young pregnant woman, which responded well to treatment with a combination of erythromycin and rifampicin. The treatment of spotted fevers in pregnancy is discussed in detail.

Adult↗
PubMed1998

Topical hyperbaric oxygen and low energy laser for the treatment of diabetic foot ulcers.

Fifty patients with chronic diabetic foot ulcers in whom conventional therapy had failed were treated with topical hyperbaric oxygen alone (15 patients) or in combination with a low energy laser (35 patients). Eleven of these patients were treated on an ambulatory basis with topical hyperbaric oxygen. The mean time the ulcer was present before therapy was 9+/-6.6 months. The mean number of treatments was 25+/-13, and the mean duration of therapy was 3+/-1.8 months. Forty-three of the 50 patients were cured. No adverse reactions were noted. Our impression is that topical hyperbaric oxygen alone or in combination with a low power laser are valuable adjuvants to conventional therapy for diabetic foot ulcers.

Adult↗
PubMed1994

Presence of infective Epstein-Barr virus in the urine of patients with infectious mononucleosis.

The presence of Epstein-Barr virus (EBV) in the blood and urine of 20 patients with infectious mononucleosis (IM) was investigated together with the clinical course of the disease, and in 9 patients up to 2-7 months after recovery. EBV DNA, analyzed by the polymerase chain reaction (PCR), was detected in the blood of all 20 patients from the first sample obtained and detected between 3 to 42 days from the beginning of symptoms and up to 2-3 months after recovery. In the urine, EBV DNA was detected in 15 out of 16 (93%) patients in the first sample obtained and detected between 3 to 50 days during the clinical course of the disease. In four patients EBV DNA was detected in the urine up to 3 months after full recovery. Seventeen out of 26 (65%) urine samples including 3 which were obtained 2-7 months after recovery infected B cells as assessed by PCR. Nine out of 12 (75%) urine samples tested induced Epstein-Barr nuclear antigen (EBNA) in the infected B-cell line. In addition to the persistence of EBV in the blood of IM patients, these studies show for the first time the presence of infective EBV in the urine during the clinical course of the disease and up to 7 months after full clinical recovery.

Antigens, Viral↗
PubMed1993

Wegener's granulomatosis with peripheral eosinophilia. Atypical variant of a classic disease.

A patient with Wegener's granulomatosis (WG) diagnosed by ultrasound-guided transthoracic biopsy of a pulmonary nodule is reported. The case is atypical because of marked eosinophilia in the peripheral blood and the pleural effusion. The granulomatous infiltrate of the lung showed the classic picture of WG without eosinophils. The patient responded dramatically to treatment with steroids and cyclophosphamide. This variant form of WG poses problems in its distinction from Churg-Strauss syndrome, and the differential diagnosis between these two entities is discussed.

Adult↗
PubMed1990

[Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections].

40 seriously ill patients with complicated urinary tract infections were randomly assigned to receive either a single daily dose of ceftriaxone or combined therapy with cefazolin and gentamicin administered every 8 hours. The groups were of equal size, similar in age (both averaged 75 years) and the sex ratio was about 1:1 in each group. 32.5% had proven bacteremia and the overall mortality was 17.5%. Both regimens were similarly effective in terms of mortality, duration of fever (3.0-3.1 days), and sterilization of the urine prior to discharge from hospital. However, the single daily dose of ceftriaxone was much more convenient to administer.

Aged↗