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Biomedical subjects

Z M Getling

Publications and source records attributed to Z M Getling.

At least 19 recordsLinked to original sources
PubMed1990

[The ultrastructural changes in the nerve fibers of the skin in psoriasis].

Electron microscopic examination of the upper layers of the derma in skin biopsy specimens from 20 patients with psoriasis, collected both in foci of lesions and those of apparently intact skin, has revealed that changes in amyelinic nerve fibers are more marked in foci of involvement. Here they may be partly explained by inflammatory processes; but since the nerve fibers are also significantly changed in apparently intact skin, we may suppose that these changes are due to other factors as well.

Adult↗
PubMed1990

[The clinico-morphological diagnosis of cancer of the sweat glands].

Comprehensive clinical, morphologic, and ultrastructural studies of 12 cases with various forms of carcinoma of the sweat glands permitted distinguishing the clinical nodular and papular-cystic forms. Histologically malignant analogs of benign tumors, primary adenocarcinomas, and unclassified tumors are distinguished. The histogenetic appurtenance of the tumors of the latter group may be identified only by ultrastructural studies that help detect a number of organ specificity signs. Electron microscopy used in the diagnosis of poorly differentiated tumors of the skin helps carry out adequate therapeutic strategy and permitted a better validated prediction.

Adenocarcinoma↗
PubMed1990

[The morphological changes in the skin of the prepuce in patients with xerotic balanoposthitis].

The authors analyze the findings of histologic and electron-microscopic examinations of skin biopsy specimens from 15 patients with xerotic balanoposthitis. The results evidence that xerotic balanoposthitis morphologically is characterized by atrophy of the epidermis, vacuolar dystrophy of the basal cells, changed structure of keratohyalin granules, presence of a vast edematous area under the epidermis, absence of elastic fibers, inflammatory cellular infiltrate under the edematous area. During initial manifestations of the disease and its progressive stage more manifest changes are detectable in the derma. Atrophy of the epidermis was not observed, a lesser edematous area was seen under the epidermis, and, in contrast to the typical pattern of sclerotic and atrophic lichen, a dense, more superficially located cellular infiltrate in the derma. Small-granular substance is detectable in the edematous area under the epidermis, as are numbers of microfibrils and this diffusely located collagen fibrils that indicate synthesis of fibrillar substances.

Balanitis↗
PubMed1989

[Mibelli's porokeratosis].

A 44-year-old patient suffering from porokeratosis of Mibelli for 27 years is described. The eruptions have involved the skin of the buttocks and the upper and lower limb flexor surface. The clinical picture of the disease may be regarded as the classical plaque form. The clinical diagnosis has been confirmed by a characteristic histologic picture with invagination of the corium mass into the epidermis (corniculate plates). Electron microscopy has shown a number of shifts in the epidermis sites adjacent to the corniculate plate and above it. The proliferative activity of the epidermis was enhanced but the keratinization processes round the corniculate plate was unchanged.

Adult↗
PubMed1989

[Electron microscopic study of Darier's follicular dyskeratosis].

Ultrastructure of the skin biopsy specimens of 10 patients with Darier's keratosis follicularis (DKF), 6 of them with the vesicular form of the dermatosis, has been examined by electron microscopy. The study has revealed dyskeratosis with tonofilament homogenization and well-developed keratohyalin granules, round bodies and granules, and acantholysis less manifest than in Hailey-Hailey's chronic benign familial pemphigus. Ultrastructural features of the skin in vesicular DKF present as acantholysis and dyskeratosis more manifest than in typical DKF. Similarity of the morphologic signs of the typical and vesicular DKF permit considering the vesicular form of this keratosis as one of DKF variants.

Adolescent↗