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Biomedical subjects

Z Makarović

Publications and source records attributed to Z Makarović.

8 recordsLinked to original sources
PubMedDate not supplied

[Colposcopic, cytologic and histologic changes in the uterine cervix caused by human papilloma viruses].

This study is an evaluation of 485 histological findings of directed biopsies, which were performed due to the cytological state of dysplasia (IIIA and IIIB) or an abnormal colposcopy finding. The analysis of cervical smears showed 18.4% of the patients to have koilocytosis, whereas 6.8% of them had colposcopically recognized cervical condyloma. The samples obtained by biopsy underwent histological examination, which confirmed koilocytotic changes in 8.5% of cases, i. e. in significantly lower percentage than indicated by cytology (t = 4.500; p < 0.001). Colposcopy findings of condyloma, on the other hand, were confirmed much more often (60.6% compared to 31.5%; t = 3.163, p < 0.001, i. e. the difference is statistically significant). Pathohistological examination verified 68.3% of cytologically recognized cases of koilocytosis, compared to 48.8% of cytologically recognized cases of koilocytosis, compared to 48.8% of those discovered by colposcopy--the difference is not significant (t = 1.822; p > 0.05). However, the joint implementation of cytology and colposcopy revealed 85.4% of koilocytoses. Compared to the results of colposcopy as the single method, the difference is statistically significant (t = 3.812; p < 0.001), but compared to cytology it is not (t = 1.879; p > 0.05). Koilocytosis is significantly more frequent in women under 35 years of age (82.9%; t = 4.218, p < 0.001) and the patients suffering from it are also much more likely to have dysplasia or CIS than those with no HPV infection (58.5% compared to 42.4%; t = 2.012, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Dysplasia and carcinoma in situ of the uterine cervix in pregnancy].

During a 3-year period, 167 women with an abnormal cytological finding (112-IIIA, 41-IIIB and 14-IV) were followed up cytologically and colposcopically in six weeks' intervals. They were evaluated during pregnancy, vaginal delivery and the puerperal period, and the cytological findings showed no progression of intraepithelial lesions into the invasive ones. Definitive postpartum pathohistological findings in 53 patients showed that 32 had in situ carcinoma, 12 severe and 7 light dysplasias, and 2 benign changes. The possibility of the false negative cytological assessments or invasive cervical carcinoma was excluded. Patholhistological and cytological findings matched in 77% of cases, whereas the degree of the former was lower in 21% and higher in 2% of the patients. In as many as 40.7% of patients the first post-delivery control cytological finding was negative. The reversible nature of these findings is emphasized, as well as the need to follow up these patients for at least one year.

Carcinoma in Situ↗
PubMedDate not supplied

[The importance of directed cytological examinations in the diagnosis of ovarian tumors].

A total of 263 cytologically examined patients with clinically suspected ovarian tumours are presented. In 164 cases (58 malignant and 106 benign tumours), the cytological finding and the definite pathohistological diagnosis were comparable, by which it has been found that the sensitivity of the method was 79.3%, its specificity 96.2%, and its predictive value 92.0%. Possible causes of false negative and false positive findings are analysed.

Ascitic Fluid↗
PubMedDate not supplied

[Evaluation of severe dysplasia and carcinoma in situ detected by directed biopsy].

Eighty women with Papanicolaou smears groups IIIa and IIIb and an abnormal colposcopic picture, where colposcopic biopsy pathologic results showed severe dysplasia or carcinoma in situ, were analyzed. Severe dysplasia was found in 51 (63.7%) and carcinoma in situ in 29 (36.2%)cases. By using methods of a definitive diagnostic value, in cases of severe dysplasia, the early diagnosis was confirmed in 24 (47.1%) cases, in 14 (27.4%) cases carcinoma in situ was detected, in 3 (5.9%) moderate dysplasia, in 2 (3.9%) mild dysplasia, and in 8 (15.7%) cases benign histologic changes were found. Carcinoma in situ detected by colposcopy-directed biopsies was confirmed, after a definitive diagnostic procedure, in 24 (82.8%) cases, in 3 cases (10.3%) severe dysplasia was found and in 2 (6.9%) cases there were benign histologic changes. The results suggest that carcinoma in situ and severe dysplasia are vulnerable lesions which can be transformed into a lower grade or even completely disappear by directed biopsies. Such an evolution is significantly more to be expected within the population with an abnormal colposcopic picture if lesions cover not more than one fourth of the cervical circumference.

Adolescent↗
PubMedDate not supplied

[Cervical pregnancy treated by conization].

Cervical pregnancy in a 23-year-old patients is presented. The local finding corresponded to criteria for the diagnosis of cervical pregnancy. The diagnosis was confirmed by an immunological test (Gonavislide) and ultrasound. Conization was applied, and in the conization material the pathologist found chorial villi with a great many trophoblasts in direct contact with the muscular cervical layer.

Adult↗