The OMED data base: standard for nomenclature.
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Biomedical subjects
Publications and source records attributed to Z Maratka.
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The aims are to present a uniform terminology (terms), which can be suitably used throughout the world for enumeration of characteristics by which an item can be identified and distinguished. Nomenclature is a list of terms classified in a logical system. Description must be as objective as possible and the terms used must be specific for the method. Terminology, definitions, and diagnostic criteria in digestive endoscopy have been published in several languages.
The classification of digestive problems into organic and functional is logical and helpful in medical practice. The diagnosis of a functional disorder must be positive--not only exclusive.
Endoscopic word database systems are not standardized. An endoscopic word reference has been developed by the World Organization for Gastrointestinal Endoscopy. The suggestion is made to develop a standard software program for gastrointestinal endoscopy based on this system or one similar.
Histological and histochemical patterns of the gastric and duodenal mucosa was investigated in nine subjects with duodenal ulcer or ulcerlike syndrome after 4 to 5 weeks treatment with cimetidine or carbenoxolone. No spectacular changes were found after carbenoxolone except for a slight increase in goblet cells in the duodenal bulb. In the patients treated with cimetidine, findings suggesting an influence of this drug on the biochemical cytology of parietal cells and some interference in the differentiation of enterocytes were established.
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Histochemical examination of aspiration biopsy specimens of the duodenum in 8 healthy volunteers and 23 patients with various gastrointestinal disorders revealed no characteristic abnormality except for a rather frequent absence of the activity of disacharidases especially of lactase. A distinct difference of disacharidase was established between the duodenum and the jejunum in some individuals. A systematic study of different levels of the upper gastrointestinal tract established the fact that the activity of brush border enzymes of enterocytes starts to appear in individually different parts of the duodenum and sometimes even as low as in the jejunum. The distribution of lysosomal enzymes and the activity of dehydrogenases display differences as well. Consequently specimens from different parts of the duodenal and jejunal mucosa are not equivalent and cannot be used alternatively for diagnostic purposes. Biopsies of duodenal mucosa are not adequate for the diagnosis of the malabsorption syndrome.
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Eleven cases of hyperplasia of Brunner's glands are reported including 10 cases of diffuse and nodular type and one case of Brunnerian polyadenomatosis. Histological changes were identified in aspiration biopsy specimens and termed "biopsy indication of hyperplasia of Brunner's glands". Polypoid pattern seen roentgenologically and endoscopically in the case of the adenomatous type was constant whereas in the case of the diffuse and nodular type it was not constant; it is suggested that this is due to irregular contraction of muscularis mucosae disrupted by protruding Brunner's glands. Most patients had epigastric distress; less than half had duodenitis.
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Constipation and diarrhea are usually defined in terms of frequency of defecation and consistency of stool. However, the subjective component in these symptoms is so great that the objective criteria cannot be satisfactory. An important additional aspect is provided by the analysis of sensations and postures in the three phases of the act of defecation (announcing, emptying, subsequent phase). Taking account of the subjective aspects may contribute to a better differentiation and classification not only of constipation and diarrhea but also of such disturbances as organic rectal disease and irritable colon.