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Biomedical subjects

Z Matĕjovský

Publications and source records attributed to Z Matĕjovský.

At least 19 recordsLinked to original sources
PubMed1997

Ossifying fibromyxoid tumor of soft parts: a report of 17 cases with emphasis on unusual histological features.

Ossifying fibromyxoid tumor of soft parts is an unusual benign neoplasm, with a tendency for local recurrence. Its typical microscopic appearance is that of a multinodular proliferation of round to spindle shaped cells separated by fibrous bands in which bone formation is often seen. Herein, we present the clinicopathologic features of 17 examples of this tumor with particular emphasis on some unusual histopathologic features that may place pitfalls in the diagnosis of this tumor, including satellite micronodules, mucinous microcysts, absence of myxoid areas, crush artifact, multiple microcalcifications, epidermoid cysts, atypical chondroid differentiation with binucleate lacunar cells, pericytic growth pattern, and malignant change. Awareness of these unusual morphologic features should lead to a search for areas displaying the more typical features of ossifying fibromyxoid tumor to arrive at a correct diagnosis.

Adolescent↗
PubMed1993

[Aggressive chondroblastoma].

The authors report three observations of rather extensive aggressive chondroblastoma and draw attention to difficulties of histological diagnosis, which result out of a less typical histological picture, in which signs of differentiation into cartilaginous tissue may be missing. Differential diagnosis may be facilitated by proper recognition of the cytologic character of chondroblasts by the positivity of S-100 protein, and by proving characteristic properties of chondroblasts in electronmicroscopic examination. In treating this type of tumors an increased risk of local recurrence (in one of our patients) and aggressive behaviour to surrounding tissues should be considered, exceptionally pulmonary metastases may develop, as was the case in one of our presented patients.

Adult↗
PubMed1990

Digital subtraction angiography in musculoskeletal tumors and other conditions.

One hundred and forty consecutive DSA examinations of various musculoskeletal diseases were analyzed with respect to the contributions and/or limits of this modern diagnostic imaging modality. Angiography remains the imaging tool of choice for many benign and malignant orthopedic conditions of bones and soft tissues, mainly when MRI is still not generally available. It remains indispensable for embolization and/or local chemotherapy. DSA has the advantage of being less invasive and it also surpasses analog arteriography in better visualization of vascular patterns hidden in hyperostosis, sclerosis, and metallic shadows. Angiographic investigations, when necessary, should therefore start with DSA.

Adolescent↗
PubMed1990

[Extensive metastases of Ewing's sarcoma in the adreno-renal area].

The authors refer to the observation of 43 years old woman with Ewing's sarcoma of the pelvic region, who displayed, a year after local extirpation of the tumour, clinically and radiographically, a metastasis in the adrenal-renal region. The patient died due to generalization of the tumour during the next year after an attempt to remove the metastasis, where a radical intervention proved impossible. Metastases of malignant tumours of locomotor apparatus into this region proved to be rare and such is the observation of the extensive affection in the Ewing's sarcoma.

Adrenal Gland Neoplasms↗
PubMed1990

[Use of cement plugs in the care of giant cell bone tumors].

The classical giant cell tumor represents a problem as the clinical, radiological and histological parameters not always exclude the tendency to local recurrences, rarely also to metastases. Surgical treatment of this tumor is characterized by a relatively high percentage of local recurrences. In the years 1965-1987 patients with 72 giant cell tumors were treated within the Prague Team for Bone Tumors. In 1980 the existing results were revised in 37 patients operated on to that time and the therapeutical scheme was changed by the introduction of new methods mainly the application of bone cement. While in 17 patients we have primarily operated on in the years 1965-1980 recurrence occurred in 36 per cent, in the period 1981-1987 in 32 patients primarily operated on the recurrence amounted to 9.4 per cent, i.e. it occurred in three patients. In these three patients it was the case of excochleation and primary filling by autografts. In 13 cases of the application of bone cement for the filling of the defect after the removal of the tumor there was no recurrence. In the average interval of 1 year since the operation bone cement was substituted by author allografts. In case of an extensive resection of greater part of the joint the application proved right of the massive allografts, fixed by stable osteosynthesis, exclusively in some cases also the application of a special tumorous endoprosthesis in the area of the hip, knee and shoulder.

Adolescent↗
PubMed1990

[Comparison of treatment of juvenile bone cysts using local administration of corticoids and surgical therapy].

The authors describe the results of the juvenile bone cyst in the group of 41 patients by the method of the application of corticoids and compare them with the results of the therapy by means of excochleation and filling the cavity of the cyst with bone grafts. In the therapy by corticoids restitutio ad integrum was achieved in 37.8 per cent and in 43.2 per cent of patients the healing was incomplete. In 5.5 per cent of cases there occurred recurrence after the cyst was healed, in 13.5 per cent there was no response to the application of corticoids. In the groups of surgically treated patients the cyst was healed in 68.8 per cent, out of which 48 per cent was restitutio ad integrum. The number of recurrence was relatively high--31.2 per cent. Both methods have their place in the therapy of bone cysts. The surgical approach makes it possible to achieve more quickly restitutio ad integrum in extensive bone cysts located at lower extremities. For the cysts affecting the humerus the method of choice is the local application of corticoids. In the therapy by steroids the authors the necessity of regular control and in case of the survival of the cyst the necessity of repeating the instillation of the steroid.

Adolescent↗
PubMed1989

[Extramedullary Ewing's sarcoma].

The authors refer to six observations of periostal Ewing's sarcoma and describe its X-ray symptomatology. It differs considerably from the commonly known picture of centrally, intramedullar-originated Ewing sarcomas and tumours, diagnosed at considerable advanced stage. The possibility of periosteal origin of Ewing's sarcoma must be considered in differential diagnosis of periostoses and the patients must be examined in a complex way, particularly by computer tomography (and in the future also by MR tomography) in order to demonstrate that the medullar space of the bone is not affected by the tumour. This enables a more considerate resection during the operation. Histological verification of the nature of the tumour and excluding presence of the tumour cells in bone marrow dissection material is necessary. It may be expected that prognosis of this form of Ewing's sarcoma while treated in a modern combined way is more favourable than in the central forms.

Adolescent↗
PubMed1988

Osteosarcoma with a clear-cell component.

The reports concerns the light microscopical and ultrastructural findings obtained in three conventional osteosarcomas with an unusually high admixture of clear cells, whose presence appeared to be responsible for the marked change in the histological pattern of these tumours. In the tumours with a prevailing fibroblastic component the clear cells were either irregularly scattered throughout the tumour in the form of small groups, or they formed large groups sharply demarcated against the fusicellular areas of the tumours. In two cases it was shown that their cytoplasm contained exaggerated glycogen deposits accompanied by the formation of glycogen-containing phagolysosomes and occasional empty vacuoles. In the third case the clear cells showed vacuolar degeneration with numerous single-membrane-bound, empty vacuoles. In contrast to the clear-cell chondrosarcoma we did not find S-100 protein in clear cells of our osteosarcomas. Such findings could be particularly significant in the differential diagnosis of bone tumours.

Adolescent↗
PubMed1986

[Mesenchymal chondrosarcoma].

Five mesenchymal chondrosarcomas of the bones, soft tissues and the orbit were subjected to histological and electronmicroscopic examination. In all instances the authors found in addition to the differentiated cartilaginous component extensive areas formed by round or spindle-shaped non-differentiated mesenchymal elements which on electron microscopic examination had a striking resemblance with Ewing's Sarcoma cells or resembled fibroblasts. The vascular portions present in all examined tumours reminded of the structure of a haemangiopericytoma. Osteoplasia found in soft tissue tumours had a non-tumourous character.

Adult↗
PubMed1985

A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, chordoma and chordoma periphericum.

The present study is based on electron microscopical examinations of 15 conventional chondrosarcomas, 1 clear cell chondrosarcoma, 3 mesenchymal chondrosarcomas, 2 so-called chordoid sarcomas (extraskeletal myxoid chondrosarcoma), 4 sacrococcygeal chordomas, 2 ecchordoses and 1 neoplasm of tibia with features of a true peripheral chordoma (parachordoma). The neoplastic cells from various types of chondrosarcoma shared a number of features with nonneoplastic chondrocytes as e.g. a well-developed rough endoplasmic reticulum and microvillous cytoplasmic processes. In clear-cell chondrosarcoma, glycogen accumulation in the tumour cells was a prominent feature. The cells of mesenchymal chondrosarcoma usually showed the characteristics of immature mesenchymal cells. In contrast, chordomas commonly contained physaliferous cells with two types of vacuoles in their cytoplasm. The first type can be most adequately characterized as intracytoplasmic pseudoinclusions of intercellular substance, whereas the other type, glycogen-containing, single membrane-bound vacuoles most probably correspond to autophagosomes (cytolysosomes). Only vacuoles of the first type were recorded in the so-called chordoid sarcoma. They were also seen in chondrosarcomas. In contrast, both types of vacuoles were identified in the above-mentioned tibial tumour which, in addition, showed even other cytological characteristics of chordoma. The findings presented here have demonstrated distinct structural relationships between chordoid sarcoma and chondrogenic tumours. On the other hand, our observation of the uncommon tibial neoplasm indicates the possibility that tumours identical with chordoma may occur at sites other than the axial skeleton.

Bone Neoplasms↗