Biomedical subjects
Publications and source records attributed to Z N Ostapiak.
The course of bronchitis with clinical manifestations of allergy is characterized by certain cytochemical features which (as compared with bronchitis without allergy) show an increase of deoxyribonucleic acid, increased permeability of the intracellular membranes of polynuclear leucocytes and lymphocytes, reduction of the content of cationic proteins and activity of acid phosphatase in the polynuclear leucocytes of the blood.
Specific (tuberculin, adrenalin) and nonspecific (ultrasound, phenol) in vitro exposures of the blood improve the diagnostic informativeness of the red cell sedimentation rate measurements. Similarity of the results of measurements, carried out by the suggested and the reference techniques in more than 550 patients, gives grounds to employ the suggested modifications of tuberculin diagnosis, of detecting a beta-adrenodependent bronchospasm, of assessing the pattern and the activity of an inflammation in pneumonias. Practical and statistical rationale for the suggested methods is given.
In vitro exposure of the blood to UV irradiation and ultrasound changes the content of cationic proteins in polynuclear leukocytes. The difference (vs. the intact blood) is diagnostically valuable, for it helps locate the inflammation in the lungs, determine the origin of the bronchial spasm, and predict resistance to relapses of pulmonary inflammations.
The authors emphasize informative inadequacy of traditional laboratory diagnosis and anti-inflammatory efficacy of treatment of chronic bronchitis. It is proposed to use a new method (Sigma-ESR) reflecting the activity and specificity of tissue processes in the lungs during inflammation that substantiates objectification of diagnosis. The technique is described.
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The paper covers the results of experimental and clinical evaluation of preventive potential of some drugs and physical factors against acute and chronic inflammation in the lungs. Standard general and local reactions related to prophylaxis are specified with consideration of underlying mechanisms. Comparative preventive potentialities of the techniques and prospects of their effectiveness prediction are discussed.
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The paper deals with ultrasound effects examined in experiments on 68 male Wistar rats with experimental pneumonia and on animals with pneumonia injected with plasma from rats pre exposed to ultrasound. Ultrasound is shown to inhibit pulmonary inflammation and lipid peroxidation. The role of humoral factors in preventive mechanism of ultrasound action is elucidated.