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Biomedical subjects

Z Ostrowska

Publications and source records attributed to Z Ostrowska.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Homocysteine, vitamin B12, and folic acid in age-related macular degeneration.

PURPOSE: Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis and thrombosis. The purpose of this study was to evaluate plasma homocysteine, red blood cell folate, plasma folate, and plasma vitamin B12 concentration in patients with exudative age-related macular degeneration (ARMD). METHODS: The participants of this study included 30 patients aged 60 to 71 years (mean age 66.2+/-3.6) with exudative ARMD. Plasma homocysteine levels were determined by high performance liquid chromatography (HPLC). Red blood cell folate, plasma folate, and plasma vitamin B12 concentration were determined using a standard kit (Dualcount Solid Phase No Boill radioassay kit for B12/folic acid, DPC Diagnostic, USA) by radioassay method. RESULTS: The plasma concentration of Hcy (14.88+/-6.23 micromol/L) in ARMD patients was significantly increased (p<0.0001) compared with the control group (8.72+/-3.34 micromol/L). We found not a significant decrease of the plasma vitamin B12 concentration in the ARMD group (476.88+/-220.91 pg/mL) compared with the control group (527.08+/-208.97 pg/mL). Red blood cell folate (158.44+/-56.30 ng/mL) and plasma folate (6.5+/-3.4 ng/mL) in ARMD patients were also not significantly decreased when compared with the control group (183.86+/-59.33 ng/mL and 7.93+/-5.05 ng/mL). CONCLUSIONS: Hyperhomocysteinemia might be one of the risk factors for the exudative form of ARMD.

Aged↗
PubMedDate not supplied

The influence of pinealectomy and single dose of melatonin administered at different times of day on serum T3 and T4 concentrations in rats.

The influence of pinealectomy and melatonin administration on the levels of total T3 and T4 plasma levels were determined by RIA method. The results of hormonal measurements were evaluated by means of Student's t-test, and the diurnal rhythm by cosinor method. It has been established that pinealectomy disturbs the T3 diurnal rhythm and caused marked changes in T4 levels during the 24 hours. Exogenous melatonin does not influence the thyroid function during the light phase. During the dark phase, however, its inhibitory effect is prevalent in pinealectomized rats, and the stimulating in sham operated rats.

Animals↗
PubMedDate not supplied

Serum ferritin, iron and transferrin in women with thyrotoxic Graves' disease before and after methimazole treatment.

We investigated iron metabolism in 47 women with thyrotoxic Graves' disease. Serum iron, ferritin, transferrin, triiodothyronine and thyroxine concentrations were RIA measured before and after methimazole treatment when patients became euthyroid. The control group consisted of 52 healthy women. We noted that serum ferritin levels and the ferritin to transferrin ration were significantly lower while the iron to ferritin ratio was higher in patients before and after methimazole therapy. Iron concentration as well as the iron to transferrin and the iron to thyroid hormone ratios were decreased only before treatment.

Adult↗
PubMedDate not supplied

Light and darkness effect on adrenocortical secretion of rats exposed to stress.

The investigations were carried out on sexually mature Wistar rats divided into three groups: control group, a group kept always in darkness, and a group exposed continually to light. In each group a subgroup was isolated which was subjected to formalin stress. In all animals aldosterone and corticosterone concentrations in adrenal venous blood were determined spectrophotometrically. Thin layer chromatography was used for separation of steroids. It was found that keeping the rats in darkness caused a fall in the concentrations of corticosterone and aldosterone, while stress caused in the rats kept in darkness a rise of the concentrations of both these hormones. Continuous exposure to light reduced the concentration of aldosterone to undetectable values and of corticosterone by 90% in relation to the control group. Decrease of hormones level was observed in the stressed and non-stressed subgroups.

Adrenal Cortex↗
PubMedDate not supplied

[Levels of melatonin in serum of patients with retinitis pigmentosa].

PURPOSE: To elucidate melatonin secretion through the pineal gland in patients with night blindness. MATERIAL AND METHODS: Blood samples for melatonin RIA assay were taken from 14 patients at 8 o'clock a.m. and p.m., before and after 3 weeks therapy with Trental, Cocarboxylase and vitamin B12. RESULTS: Usual rhythm of melatonin secretion was demonstrated. The applied treatment influenced melatonin secretion in the youngest group of patients. CONCLUSION: Damage of the photoreceptors in the retina affects melatonin secretion and its circadian rhythm.

Adolescent↗