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Biomedical subjects

Z Piasecki

Publications and source records attributed to Z Piasecki.

At least 19 recordsLinked to original sources

[Functional evaluation of the prostatic urethra by means of transrectal ultrasound].

Transrectal ultrasound (TRUS) is the popular tool in the diagnostics of benign prostatic hyperplasia (BPH) mainly visualizing the static image of prostate with closed urethra. The aim of this study was to observe the changes of the shapes and dimensions of prostatic urethra during micturition using transrectal probe, with simultaneous uroflowmetry. 174 men were examined. 58 of them (aged 20-40 y.) non obstructed--control group, 57 (aged 41-60 y.) and 59 (aged 61-80 y.) with bladder outlet obstruction (BOO) symptoms. TRUS with videorecording in upright position was done. Simultaneously uroflowmetry was performed. Maximal dimensions of the cross-sections of the prostatic urethra in sagittal plane were taken on two levels. First at the bladder neck (S1, mm), second in the middle of the prostatic urethra (S2, mm). The relations between dimensions and uroflowmetry were analyzed using also the average of the sum od S1 and S2 (S3 mm). The average dimension of S1 and S2 decreased with age from 6.3 and 7.0 mm in control group, to 5.1 and 4.5 mm in patients over the age of 60. The average of S3 decreased from 13.3 to 9.5 mm. In all groups statistically significant relations between maximal flow rate (Qmax) and S1, S2 were noted (p < 0.001 and p < 0.05). Particularly strong relations between Qmax and S3 were stated (p < 0.0001). On the base of these results the nomograms were created which allow to calculate the approximate Qmax basing on the prostatic urethra cross dimension. The TRUS measurement of the prostatic urethra cross sections during micturition allows to calculate approximately the Qmax, especially on the base of S3. The observation of the changes of the shapes and dimensions of the prostatic urethra during micturition will make easier to localize and state the character of BOO. The low Qmax with simultaneous correct cross dimensions of the prostatic urethra can suggest the detrusor insufficiency.

Adult↗

Vascular architecture of human urinary bladder carcinoma: a SEM study of corrosion casts.

The vascular architecture of five advanced invasive papillary tumours of the urinary bladder was investigated using corrosion casting and scanning electron microscopy. The superficial vasculature was composed predominantly of capillary systems of two types: dense flat networks with numerous interconnections and tightly packed tortuous loops, forming multiple irregular folds that reflected the papillary morphology of the tumours. The capillaries were supplied and drained by numerous straight nonanastomosing arterioles and venules, which arose by way of multiple branching of larger vessels originating from the mucosal plexus of the bladder. Differences between the tumours in the spatial arrangement of these vessels probably reflect different growth dynamics. The intramural parts of the tumours contained a chaotic network of straight, uniform capillaries with numerous sprouts, which was very different from the superficial capillary system. It is postulated that different angiogenesis-targeted growth factors may be expressed in the phases of exophytic growth and muscularis invasion of the tumour, leading to the formation of different microvascular patterns.

Arterioles↗

[Urolithiasis].

Epidemiologic investigation did not show any special environmental combination causing urinary calculi creation. The disease concerns usually people between 25-50 year old. Most of the urinary calculi are compound of calcium oxalate and phosphate. In contaminated urine more often ammonia-magnesium phosphate. General constitutional factors having influence on urinary stones creation are specific gravidity, crystallization inhibiting factors concentration, hypercalcuria, urine acidity, hyperoxaluria and urinary tract infection. Unilateral, single urine stone is usually the effect of the local factors. Bilateral and multiple urinary stones are usually the effect of the local factors. Bilateral and multiple urinary stones usually are the effect of general constitutional and environmental factors. Complaints depend on the stone localisation, its dimensions and period of the disease. Nowadays most of the urinary calculi localised in the kidneys and ureters are treated with ESWL, PCNL and URS. Staghorn calculi are treated with the combination of PCNL and ESWL or operatively. Urinary stones localised in the bladder can be the consequence of descending ureteral stones, but usually they are created in the bladder as a consequence of the subvesical obstruction. The treatment is based on transurethral lithotripsy with simultaneous obstruction treatment by electrosurgery of the prostate or bladder neck or visual urethrotomy. Large and hard stones can be removed by cysto-lithotomy. Metafilaxis is the recurrences prevention, based first of all on diminution of crystalloid concentration and their solubility in the urine and providing crystallization inhibiting factors. Calculi composed of urine acid can be treated conservatively by their dilution.

Adult↗

[Coexistence of obstructive lung diseases and lung cancer].

Connection between histological type of lung cancer and existence of clinical and spirometric symptoms of COPD was analysed in 110 lung cancer patients (64 small cell, 23 adenocarcinoma, and 23 squamous). It was shown that adenocarcinoma was significantly more frequent among subjects with values of FEV1%VC over 70 than among subjects with small cell and squamous lung cancer. Also subjects with values of FEV1% VC over 70 had significantly higher oxygen blood pressure, and clinical and radiological symptoms of COPD were less intensive than in subjects with values of this index below 70. There was no correlation between histological type of lung cancer and bronchoscopic symptoms of bronchitis and radiological symptoms of emphysema.

Adenocarcinoma↗

[Analysis of patients registered in outpatient departments for tuberculosis and lung diseases in group VI N (neoplastic) during the first half of 1995].

2115 cases of chest neoplasms were registered during the first six months of 1995 in Pulmonary Outpatient Departments in Poland. In 865 (40.8%) patients squamous cell cancer was diagnosed, in 344 (16.2%)--small cell lung cancer, in 174 (8.2%)--adenocarcinoma, in 107 (5%) other types of lung cancer and in 5.6% of cases--lung cancer with undefined histology. Predominated subjects aged from 60 to 69 years (43.5%). Lung cancer under 50 years of age was observed significantly more often among women (25.8%) than among men (13.5%). Moreover adenocarcinoma was much more frequent among women than men and significantly more cases of lung cancer were recorded in nonsmoking women. Diagnosis was established during the first 4 weeks in 38.9% of patients but 23.6% of patients have waited for it more than 39 weeks. Surgical treatment was advised in 16.9% of subjects, radiotherapy in 14.3% and 26.4% of patients underwent chemotherapy. Treatment analysis was presented according histological type of lung cancer. Occupation, performance status, clinical stage of the disease, prevalence of cancer in patients families were also analysed.

Aged↗

[Prevalence of diagnosing extrinsic allergic alveolitis in Poland in the years 1990-1994].

Poland is the country, where almost 40% of population inhabit rural areas. So EAA may be an important health problem. The aim of the study was to assess incidence of EAA in different districts in Poland. We asked hospitals to send us lists of patients with diagnosis of EAA established in the period of 1990-1994. In some hospitals we collected information by ourselves. This way, we have got data concerning patients with EAA. The highest prevalence of EAA 1.5-7.0/100,000 population was observed in eastern and south-western regions of Poland. Eastern Poland is rural area with small not specialised farms and possible high exposure to EAA antigens. In south-western Poland (Silesia) keeping pigeons is a very popular hobby, which may explain high incidence of EAA.

Adult↗

[Effect of selected socio-economic factors on incidence and outcome of tuberculosis in Poland].

The purpose of the paper was to verify the widely held opinion about the influence of socio-economic conditions on tuberculosis incidence and outcome. The analysis of the relationship between different socio-economic factors and tuberculosis shows that level of education seems to be the most important indicator. The level of education of tuberculosis patients in Poland is lower than the average. Together with the standard of living it differentiates patients with regard to clinical form of the disease-the lower the level of education and standard of living conditions, the more fibrocavernous forms. The analysis also indicated that the level of education and employment or unemployment did not influence the choice of treatment regiments but influenced the outcome of treatment.

Adult↗

[Results of anti-tuberculosis treatment of patients with tuberculosis--children and adolescents treated in Poland in 1993].

Treatment of 581 new cases tuberculosis in 215 children and 366 adolescents reported in 1993 were followed up for 12 months. The results show that 96.6% bacteriologically confirmed cases were cured (93.8% of children and 97.2% of adolescents). Among 409 bacteriologically negative cases (183 children and 222 adolescents) only in 7 (4 children and 3 adolescents) i.e. in 1.7% no radiological improvement was observed. 75.7% of cases BK+ received 4 drugs treatment regimen-85.4% adolescents and 40.6% children. Children with bacteriologically negative tuberculosis were treated with 2 drugs regimen -(53% of cases) and with 3 drugs regimen 43.2% of cases, while in adolescents majority of cases received 4 drugs (59.0%) or 3 drugs (33.8%). In almost all regiments there were INH and RMP. In spite of high efficacy of applied regimens, the duration of treatment was relatively long. In children BK+ , in 87.8% of cases it was longer than 6 months (in 43.8% of cases it was longer than 9 months). In adolescents BK+, in 81.2% of cases duration of treatment was longer than 6 months (in 34.7% it was longer than 9 months). Among cases BK(-), in 82.5% of children duration of treatment was longer than 6 months and 53.7% adolescents BK(-) were treated longer than 6 months.

Adolescent↗

[Deaths from asthma, bronchitis and pulmonary heart disease in Warsaw in the years 1993-1994].

By the regular checking the death certificates in the municipal offices in 7 districts of Warsaw, the morality rate from asthma has been established as 2.98/100.000, from chronic bronchitis as 8.71/100.000 and from pulmonary heart disease as 6.27/100.000. During one year of this survey only 15 deaths (4.7%) from these diseases were below age of 50.67% of patients died in hospitals and 22 (7%) died suddenly (at home). In general, deaths reported as the results of COLD were only 1.59% of the total number of deaths in Warsaw (21.530). 6.9% of all death certificates were without clinical diagnosis (Number 798 of ICD)-described as "natural death", "death before doctor's arrival" or "noncriminal death". Authors discuss the problem of over- and under-diagnosis of asthma as the cause of death, the historical background of asthma mortality and also put the question of the righteousness of regard the pulmonary heart disease as the primary cause of death.

Aged↗

[Comparative study of BCG vaccines: Polish, Danish and Japanese].

In a group of 1111 school children aged 12 years from two selected town in Poland (Rzeszów and Ostrołeka) a comparative study of three BCG vaccines was performed, the Polish, the Danish, and the Japanese. Tests for viability of the vaccines gave the following results: for the Polish vaccine 17680000 culturable particles in 1 mg; the Danish--12060000, and the Japanese--43540000 respectively Children eligible for vaccination were selected on the basis of prevaccination tuberculin testing with 2 TU tuberculin RT-23 with Tween 80. All the three vaccines gave high level of postvaccination tuberculin reactions measured after 10 weeks. In more than 30% of children these reactions were higher than 15 mm. The mean postvaccination reactions after the Polish vaccine was 14.2 mm (s.d.3.7), after the Danish--13.7 mm (s.d.3.9), and after the Japanese 14.9 mm(s.d.3.0). The difference between the Danish and the Japanese vaccines was statistically significant, but between the Polish and the other two vaccines was not. It was also formed that children with larger postvaccination tuberculin indurations had larger diameter of preview BCG scars.

Age Factors↗

[Tuberculosis in the central register for tuberculosis].

Applied methods and results of antituberculosis treatment of all registered patients in 1990 in Poland are presented. Tuberculosis prevention was achieved in 91.9% of sputum-positive patients similarly, diagnostic mistakes were detected in 10% patients with non-bacteriologically determined tuberculosis. In one year since registration 7.7% of sputum-positive patients and 3.9% of patients with non-bacteriologically confirmed tuberculosis have been dying in one year since registration time. Majority of patients in Poland were treated too long because of tuberculosis.

Adolescent↗

[Verification of tuberculosis prognosis in Poland to the year 2000].

In 1978 year a tuberculosis prognosis in Poland up to 2000 year was prepared in the Institute of Tuberculosis and Lung Diseases in Warsaw, according to epidemiological and epidemiologic-metric model (efficacy of "diagnosis-therapy program" from 60 to 90% and efficacy of BCG vaccination to 60%). The aim of study was to compare epidemiological data for registered tuberculosis cases in 1980-1990 (incidence morbidity and mortality) with the same parameters presented in prognosis for 1980-1991). Efficacy of analyzed programme was similar to predicted values: for incidence of tuberculosis-64%, for morbidity-65% and for mortality-66%.

BCG Vaccine↗

[Natural history of pulmonary hypertension in chronic obstructive lung diseases and the usefulness of the simple noninvasive methods of its diagnosis].

In 47 patients with chronic obstructive pulmonary disease and 19 patients with idiopathic pulmonary fibrosis pulmonary haemodynamics were studied. Pulmonary arterial pressure was compared with non-invasive lung function tests, ecg and the chest X-ray. Correlations between pulmonary arterial pressure and some of those parameters were found. Investigations were repeated after 3 or 5 years depending on severity of pulmonary hypertension initially found. The progression of pulmonary hypertension was found. It was accompanied by intensification of non-invasive indices of pulmonary hypertension. More than half of patients with initially severe pulmonary hypertension (> or = 30 mmg Hg) did not survive 3 years.

Adult↗

[Cellular analysis of bronchoalveolar lavage fluid. I. Detection of macrophage populations].

The aim of the study was to compare the results of routine counts of percentage of BAL macrophages, using morphological differential staining method--Pappenheim stain (M) and staining for nonspecific esterase activity (E) with those obtained by APAAP technique, using specific for monocytes (macrophages monoclonal antibodies (Ki-M1) and the complex APAAP (alkaline phosphatase--mouse anti alkaline phosphatase complex). The mean counts were comparable, although different criteria of estimation were used. Significant differences were seen in smokers when the criteria were based on morphology and expression of surface antigens. The results indicate that correct estimation of macrophage counts and their characteristics (enzymatic activity, expression of surface antigens) can only be made using many methods based on various criteria of estimation.

Adult↗

[Smoking habits, knowledge and attitude of pulmonologists concerning problems of smoking in Poland].

An analysis was carried out on 850 self-report questionnaires sent to Polish pulmonologists on their knowledge and attitude toward smoking. In the sampled population 38% of the males and 29% of females smoked. Smoking was dated as first among various noxious factors in human pathology. The knowledge of harmful effect of smoking was restricted to the cardio-respiratory system. Part of the responders, mainly smokers believe that smoking less than 15 cigarettes is harmless. ++Ex-smokers were most active in smoking cessation programs. Knowledge of harmful effect of smoking and cessation programs by physicians is unsatisfactory and teaching programs concerning this problem is mandatory.

Adult↗

Psychological status of COPD patients on long term oxygen therapy.

We evaluated the psychological status of chronic obstructive pulmonary disease patients with chronic respiratory failure, who were qualified for or on long-term oxygen therapy. Forty eight patients were examined. The patients' psychological status was assessed by means of the following methods: detailed clinical interview, the Taylor Manifest Anxiety Scale (MAS), Beck's Depression Inventory, and Tylka's Psychological Evaluation of Rehabilitation Efficiency Scale (SOPER). The study demonstrated that the great majority of patients presented a high degree of anxiety, depression and psychological tension, had low self-esteem and did not believe in the efficiency of therapy.

Anxiety↗