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Biomedical subjects

Z Religa

Publications and source records attributed to Z Religa.

83 records · Page 5Linked to original sources
PubMedDate not supplied

Biological heart valve--an alternative to mechanical valve.

Bioprosthetic heart valve, derived from human or animal tissues is a commercial, implantable valve characterised by good haemodynamic parameters, low haemolysis ratio and satisfactory durability. Until now, its wide-spread therapeutic use has been limited by the progressing leaflet calcification. The aim of the paper is to present the benefits, adverse reactions as well as problems associated with the improvement of this bioprosthesis.

Animals↗
PubMedDate not supplied

Heart retrieval for cardiac homograft.

BACKGROUND: The use of homograft tissue instead of various artificial materials in contemporary cardiovascular surgery, although limited by the constant shortage of donor organs, has become the clinically preferable procedure. The proper technique of heart retrieval, with strict donor qualification criteria and sterility procedures, is one of the key points in the successful preparation of allografts to be used later in a selected group of patients undergoing cardiac surgery, especially in the repair of pediatric congenital heart defects. MATERIAL AND METHODS: The article presents the most popular surgical technique to use for retrieving a heart for cardiac homograft in multiorgan procurement and routine autopsy, including the immediate preliminary preparation and transport, as recommended by the majority of tissue bank institutions. The qualification criteria for tissue donation, delicate preparation techniques, and sterility protocols are also important issues for successful cardiac homograft retrieval. Recently a tendency towards a growing number of pediatric donors can be observed. The techniques presented in this article should also be applied in cases of homograft retrieval from pediatric donors. RESULTS: This article analyzes our seven-year-long experience, involving a total number of 608 hearts retrieved for cardiac homografts, with special attention to the main reasons for disqualification of the organs delivered to the tissue bank. CONCLUSIONS: 1. The procedures for the sterility of tissue retrieval, especially in autopsies with heart retrieval, although they may sometimes be difficult for the surgeon or pathologist, are necessary to provide maximum benefit from harvested tissues. 2. The proper technique for pediatric homograft retrieval is twice as important in tissue delivery protocols.

Autopsy↗
PubMedDate not supplied

Electrophysiologic properties of transplanted human heart with and without rejection.

Twelve male heart transplant recipients underwent routine electrophysiologic evaluation. None were taking cardioactive drugs, and only two had symptoms of arrhythmia. Two patients had endocardial VVI pacemakers because of previous early sinus node dysfunction. With simultaneous endomyocardial biopsy, we found seven patients with no evidence of rejection (group 1) and five patients with mild rejection (group 2; three initial or mild; two definite rejection). In two group 1 patients with presyncope, corrected sinus node recovery time was prolonged, and pacemakers were implanted into the endocardium. In all patients atrioventricular conduction was normal. One patient had evidence of functional duality of anterograde atrioventricular nodal conduction. In group 2 patients prolongation of effective refractory period of the donor atrium, functional refractory period of the atrioventricular node, and effective refractory period of the right ventricle were observed. This prolongation of refractoriness may be one of the earliest markers of rejection.

Arrhythmias, Cardiac↗
PubMedDate not supplied

Experimental method of producing total cerebral ischaemia in dogs.

Experimental method of producing total cerebral ischaemia in dogs. Acta Physiol. Pol., 1977, 28 (6): 585-588. It is very difficult to produce complete cerebral ischaemia in dogs in view of very abudant anastomoses between branches of carotid and vertebral arteries and muscle arteries. The methods applied for this purpose are technnically difficult and lead frequently to spinal cord injury or major metabolic distrubances in the whole organism. The reported investigations were carried out for elaboration of a method which would not have these disadvantages. Cerebral ischaemia was produced in dogs occluding the brachiocenhalic trunk and the left subclavian artery. The blood flow to the intercostal arteries and through them to the spinal artery was interrupted by means of a bypass between the aortic arch and the abdominal aorta. Isoelectric EEG line and lack of blood flow from the punctured carotid arteries were the criteria of complete ischaemia.

Animals↗