Biomedical subjects

Z Rycembel

Publications and source records attributed to Z Rycembel.

4 recordsLinked to original sources

PubMedDate not supplied

[Statistical analysis of cerebrospinal fluid acid-base equilibrium and cerebrospinal fluid lactate concentration in cases of brain tumors, cerebrocranial injuries and meningoencephalitis].

A statistical analysis of CSF lactate concentration and CSF pH and PCO2 was performed. The values were obtained from 211 samples taken from 76 neurosurgical patients. The values of pH and pCO2 were classified in three groups corresponding to the following three ranges of lactate concentration: below 15 mg%, 15-30 mg%, over 30 mg%. The mean values and standard deviations were calculated: suitable tests: F, t (Student), C (Cochran and Cox) were used. It was established, that statistically significant changes of CSF acid-base balance were present at lactate levels over 30 mg%. Next, the patients with lactate concentrations over 30 mg% were analysed. They were divided into three groups according to etiology: inflammatory changes, injuries, tumours. It was shown, that the CSF acid-base balance in patients with brain tumours is less disturbed then in patients with inflammatory changes or brain injury.

Acid-Base Equilibrium↗

PubMedDate not supplied

[Hyperventilation and mannitol administration during surgery in patients with space-occupying intracranial lesions].

The aim of this work was to evaluate the effect of hyperventilation and mannitol on brain volume during neurosurgical operations. The material comprises 30 cases of supratentorial tumours. pO2, pCO2, pH and lactate concentration were determined in the arterial blood and in 7 cases also in the CSF. It was established that hyperventilation sometimes fails to decrease ICP; it was observed that hyperventilation was more effective in decreasing brain volume of the pCO2 level decreased by 14,6 mm Hg on the average. The joint use of hyperventilation and hypertonic mannitol was found to be more effective. Neither of the above methods was effective in the case of cystic tumors.

Adolescent↗

PubMedDate not supplied

[Statistical correlation between lactate concentration and acid-base equilibrium in cases of brain tumors, craniocerebral injuries and meningitis].

Statistical significance of correlations between lactate concentration and pH value as well as pCO2 in the cerebrospinal fluid was assessed in patients with brain tumours, craniocerebral injury and meningitis. After calculation of correlation indices it was found that with increasing lactate level the correlation between this level and the pH and pCO2 of the cerebrospinal fluid increases. Correlation coefficients were far from their maximal values (+1 or -1) which indicates absence of a direct cause-and-effect relationship between lactate concentration and both remaining values. The analysis of results in the group with lactate level exceeding 30 mg/100 ml demonstrated lowest correlation coefficients between these values in patients with meningoencephalitis.

Acid-Base Equilibrium↗

PubMedDate not supplied

[Osmotic serum pressure in patients treated with furosemide and hypertonic mannitol solution].

In patients with expanding intracranial lesion syndrome osmotic pressure of the serum was measured during administration of furosemide or 20% mannitol solution. Mannitol was administered by two methods: a) a dose of 1.5 g/kg during 3--4 hours, b) a dose of 1 g/kg for about 20 min. When mannitol was administered slowly the osmotic pressure of the serum at the end of infusion was 11--15% above the initial one and returned to the initial level 30--60 min. after the end of infusion. With rapid infusion the peak rise of pressure was observed after 30 min. usually after the end of infusion, and after one hour the pressure returned to values approaching the initial ones. Furosemide in a dose of 40 mg intramuscularly or intravenously caused slight changes of osmotic pressure reaching 13 mOsm/l.

Blood↗