The efficacy of mianserin (Lerivon) in various forms of depression.
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Biomedical subjects
Publications and source records attributed to Z Rydzyński.
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In the past two hundred years, views of the etiology of delinquency have developed from the extreme constitutional direction or line of thought through theories considering social factors to be solely responsible to the assumption of a combination of constitutional and social factors. Theses of social misadaptation as a source of delinquency, which were inaugurated by Soviet criminologists, could also be confirmed by the results of a large-scale investigation conducted in Poland. The combination of two factors (limited psychic power and negative social influences) was found to be the most frequent cause of criminal acts.
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Results are reported of three years' experiments on the use of psychotropic drugs in the treatment of 240 encephalopathic children between the ages of 6 and 15 years, who received 322 treatments in the clinic or ambulatory. The authors consider psychotropic drugs a good symptomatic medicament, helping to remove, alleviate or correct symptoms like psychomotor disturbances, distractability of attention, restlessness, tension, anxiety, night enuresis, explosivity, irritability, disturbed sleep etc. Effects of treatment are much better owing to the fact that patients are made more accessible to psychotherapy and psychagogic measures. Chlorpromazine, glutaminic acid and vitamins of the B group were particularly effective in the treatment of motorically excited encephalopaths with a passive attitude towards their surroundings.
Among children causing educational difficulties there is, according to the author, a much greater number of encephalopaths with BTEC than it is commonly assumed. Better diagnostic methods help more and more often to diagnose organic changes in the so-called difficult children. The present report gives a clinical picture of encephalopathy after BTEC. Studies were made on a group of 500 children who had suffered brain trauma of various kinds during their foetal life or early childhood. Symptoms of the infantile psychoorganic syndrome and character disorders were the most significant features of encephalopathy after BTEC. Furthermore, the children presented changes in the EEG and a lowered IQ score (not very markedly, as a rule). Focal neurological changes were rare. Basing on the fact that character disorders are a most typical feature of encephalopathy, the author classified encephalopaths as belonging either to the group of bradykinesia or that of hyperkinesia. Each of these groups has further been subdivided into those comprising the common, the asocial and the anxious type, according to the encephalopaths' attitude toward their environment.
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