[Phenoxyacetamide derivatives with potential anti-inflammatory action].
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Acetamides↗
Biomedical subjects
Z Ryznerski
Publications and source records attributed to Z Ryznerski.
[Synthesis and anti-inflammatory properties of N-(2-carboxyphenyl)-phenoxyacetamides].
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Acetamides↗
Design of a new prostaglandin synthetase inhibitors in a group of N-(2-carboxyphenyl)phenoxyacetamides and their antiinflammatory activity.
We propose to use in vitro tests for the design of antiinflammatory drugs. These tests are inhibition of prostaglandin synthetase and binding to albumin. The antienzymic potency of a compound is a good indicator of its local antiinflammatory activity. The difference between the antienzymic and the albumin ligand potencies of a compound roughly correlates with its systemic antiinflammatory activity. We found it rewarding to use de novo models for studying structure-activity relationship within our series of prostaglandin synthetase inhibitors. It is supposed that the general chemical character of prostaglandin synthetase inhibitors inclines to a wide application of the additive mathematical model of Free and Wilson for the design of antiinflammatory drugs.
Animals↗
Investigation on cyclic guanidine derivatives. II. Synthesis and properties of 2-cycloalkylamino-tetrahydropyrimidinedione-4,6 derivatives.
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Chemical Phenomena↗
[Studies on pyrazole derivatives. IV. Synthesis and studies of 6H, 7H-pyrazolo-(3,2-b)-thiazole-1,2,4 derivatives].
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Amines↗
[Studies on pyrazole derivatives. 3].
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Chemistry, Pharmaceutical↗
Synthesis and properties of 7-hydroxyalkyl-8-benzylaminotheophyllines.
The synthetic routes leading to 7-beta-hydroxyethyl- (I) and 7-beta-hydroxypropyl-8-benzylaminotheophylline (II) were described. Particularly the opening of oxazolidine ring in easy available oxazolidine-(2,3-f)-theophyllines with benzylamine was investigated. The structure of I, II and acetyl derivatives Ia, Ib, IIa and IIb was also confirmed by UV spectra.
Animals↗
Synthesis and pharmacological properties of phenoxyethylpiperazine derivatives.
Salts of new 1-phenoxyethylpiperazines 1-5, their 4-amidine derivatives 6-10 and 4-phenoxyacetyl derivatives 11-15 have been obtained. Some of them were screened for their cardiovascular activity.
Animals↗
The synthesis of some pyrazolyl-ureas.
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Methods↗
Synthesis of phenylphenoxyacetamide derivatives with potential antiinflammatory activity.
Twenty four derivatives of N-(phenoxyacetyl)-p-aminophenoxyacetic acid have been obtained. The tests of the in vitro inhibition of prostaglandin synthetase revealed that compounds 19 and 24 have the activity similar to that of Naproxen.
Animals↗