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Biomedical subjects

Z S Khlystova

Publications and source records attributed to Z S Khlystova.

At least 19 recordsLinked to original sources
PubMed2006

[Histophysiology of lymphocyte-tissue complexes in human fetal intestine].

Using histochemical and immunological methods, the development of lymphocyte-tissue complexes in the distal part of human fetal intestine (appendix, Peyer's patch) was studied in relation to the changes taking place in the ileocecal lymph nodes. It was found that this autonomous gut immune system started to function in the second trimester of fetal development. It is dominated by T-cell system of the immunity. After the appearance of meconium in the intestinal lumen, the phenotypical diversity of lymphocytes within the organ was increased, but it did not reach the level found in mature organism. The ileocecal lymph nodes are distinguished by their lymphocyte composition as a T-cell depot in this interorgan and intertissue system, which provides essential homeostasis of the developing fetus.

B-Lymphocytes↗
PubMed2005

Embryological approach to studies of stem cells.

Based on the findings of their own studies on embryonic histogenesis of human tissues and published reports, the authors determined the time limits of the existence of human embryonic stem cells and type of their determination in divergent development of tissues in different organs. Realization of genetic information of embryonic stem cells during tissue embryogenesis was studied. This information is realized by the cambium. Variability of all tissue processes is possible only within their own embryonic primordium; prospects of the mesenchyma development in an adult body is discussed.

Embryo, Mammalian↗
PubMed2003

Thymalin in developing respiratory organs of human fetus.

We studied the appearance of immunomodulator thymalin in human respiratory organs during early embryogenesis. Thymalin accumulated in young cells of airway epithelium. In the alveolar part thymalin-positive cells were diffusely spread. Mature T cells (CD3+) and the main regulatory elements (CD4+ and CD8+) were detected during the same period in the lungs in the absence of thymic microenvironment. The function of immune elements forming in fetal lungs is local protection of the fetus from potentially aggressive maternal cells and infectious agents entering the body through the trachea and fetal blood vessels.

Adjuvants, Immunologic↗
PubMed2002

Thymic hormones in human fetal skin epidermis.

Thymic hormone thymalin is detected in young epidermal cells of human fetuses. Its content varies with gestation age. Maturation of keratinocytes in the epidermis is paralleled by a decrease in the population of young thymalin-positive cells. By birth they are located on the basal membrane and in some adjacent layers. This regularity was seen in different parts of the body.

Epidermal Cells↗
PubMed2002

Age-related changes of thymalin content in human epidermis.

Immunomorphological analysis revealed the presence of thymalin in human epidermis and in fetal reticuloepithelium. These structures are developed from the common embryonic primordium ectoderm. In embryos and adult humans thymalin is present only in young epidermal cells, which undergo age-related involution. By the age of 70 years, the layer of thymalin-containing cells looks thinned and discontinuous. The content of thymalin, a thymic factor, decreases with age.

Adult↗
PubMed2002

[Immunologic characteristics of the thymus of aged CBA mice after implantation of human fetal tissue].

The effect of human fetal tissues (hypothalamic, liver, spleen, adrenal, ovarian, testicle, uterine, prostatic, gut, placental cells) collected from the fetuses at the 16-22 weeks of prenatal development, on the cytological structure of the thymus of 2-years old CBA mice in 7, 14, 42 and 64 days after start of treatment has been studied using morphological and immunological methods. The data obtained suggest that the implantation of human fetal tissues does not stop totally, but postponed age involution of thymus.

Aging↗
PubMed2000

Development of endocrine and lymphocytopoietic functions of the thymus in human embryogenesis.

The endocrine function of the thymus develops earlier than lymphocytopoietic. Thymalin is produced by epithelial cells in the thymus primordium. It is released into the blood and regulates differentiation of T lymphocytes in the liver, the initial hemopoietic organ. The hormonal and lymphopoietic functions of human thymus are united on weeks 7.5-8 of embryonic life.

Epithelial Cells↗
PubMed1991

[Development of the immune system in human ontogenesis].

The lecture presents information on the development of the immune organs in human foetus (thymus, spleen, lymph nodes, tonsilla, appendix, Peyer's plaques and blood) on the basis of literature and author's own data. Phenotypic composition of T- and B-lymphocytes in each organ and in the blood are given in both foetus and adults. The information presented is valid for the understanding of congenital immunodeficiencies and immunological confrontation between the mother and the foetus. It is shown that the thymic hormones may be present in the cells of some other organs close to the thymus by their origin.

Aging↗