PubMed Health⌕ Search

Biomedical subjects

Z S Markova

Publications and source records attributed to Z S Markova.

At least 19 recordsLinked to original sources
PubMed2001

[Inheritance of Wolff-Parkinson-White syndrome and evolution of its clinical symptoms in families of patients in a prospective trial].

Medicogenetic examination was conducted in families of 46 patients (21 women and 25 men aged 16-74 years) with Wolff-Parkinson-White (WPW) syndrome. A total of 256 relatives were investigated (136 women and 120 men aged 2 to 85 years). As a result, the diagnosis of preexcitation syndrome and phenomenon was made initially in 75(29.3%) of the relatives: WPW syndrome, Clerc-Levy-Cristesco (CLC) syndrome, CLC phenomenon was made in 6(2.3%), 27(10.6%) and 42(16.4%) relatives, respectively. Additional conduction pathways in the families with WPW syndrome are inherited by the autosome-dominant type with penetrability 0.94(94%) and clinical polymorphism. Prospective observation of the families revealed evolution of the clinical symptoms (development of arrhythmia) in the relative with CLC or WPW phenomenon in unfavorable exo- and endogenic factors. WPW syndrome evolution in the patients ran with aggravation of arrhythmia though 12 patients showed improvement.

Adolescent↗
PubMed1998

[Gopten (trandolapril) in the treatment of chronic heart failure in patients with ischemic heart disease].

AIM: To investigate clinical efficacy of angiotensin-converting enzyme inhibitor trandolapril and its effects on myocardial function. MATERIALS AND METHOD: 20 patients with ischemic heart disease (IHD) aged 33-74 years with chronic cardiac failure NYHA class II-IV. 4 of them survived myocardial infarction. In addition to the routine tests, the patients underwent echocardiography, radionuclide ventriculography. Trandolapril was given once a day for 28 days in a dose 2 mg, then a repeat examination was performed. RESULTS: Trandolapril produced a subjective effect in 80% of patients. There was also improvement of hemodynamic parameters, an increase in the ejection fraction, sensitivity to nitroglycerin, decline of asynchrony. The drug was well tolerated. CONCLUSION: Trandolapril (Gopten) is effective in IHD patients with chronic cardiac failure.

Adult↗
PubMed1998

[Prestarium treatment of essential hypertension].

The aim of the study was to assess prestarium effects on central and renal hemodynamics, blood lipids in hypertensive subjects. Prestarium was given in a daily dose 4-6 mg to 30 patients with essential hypertension stage II free of cardiac decompensation and renal failure. Echocardiography, tetrapolar chest rheoplethysmography with assessment of hemodynamics, radionuclide tracing of renal blood flow, tests for cholesterol and blood electrolytes were made before treatment, on treatment weeks 2-3 and 12. It was found that prestarium lowers blood pressure and total peripheral vascular resistance. Myocardial conductivity was not affected, whereas renal circulation activated. Low-density lipoproteins cholesterol fell. No significant changes in electrolytes were seen. The drug was well tolerated. In view of good clinical effect and tolerance prestarium is recommended for treatment of essential hypertension stage II in the absence of cardiac decompensation and renal dysfunction.

Adult↗
PubMed1997

[Minilaparotomy in surgical treatment of calculous cholecystitis].

A set of instruments devised by the CAN company was used in performing cholecystectomy in 15 patients. It proved adequate for the operative situation and allowed surgical manipulations to be carried out through a 30-50 mm minilaparotomy. Cases in which the approach had to be widened or intraoperative complications occurred were not encountered. The indices of external respiration function and the volumetric parameters decrease a little but are rapidly restored during the postoperative period. This confirms the mild traumatic character of the operation and is consistent with the absence of pulmonary complications and negligible manifestation of postoperative intestinal paresis.

Adult↗
PubMed1997

[The possibilities of isoptin treatment of pulmonary hypertension in patients with chronic obstructive bronchitis].

The study included 30 patients with COB coursing from 5 to 15 years, free of chronic cor pulmonale symptoms. All the patients had moderate obstructive impairment of pulmonary ventilation with hemodynamic disorders and defects in myocardial contractility indicating the presence of transitory pulmonary hypertension (PH). Patients of the control group received conventional therapy. It was combined with isoptin-retard (240 mg/day) in the study group. The treatment produced a positive effect in all the patients, but those of the study group exhibited more pronounced decrease in pulmonary artery pressure, achieved better hemodynamics and myocardial contractility. Isoptin-retard in daily dose 240 mg is recommended in COB patients to prevent onset of chronic cor pulmonale.

Adult↗
PubMed1994

[The volumetric blood flow in the carotid arteries of healthy subjects].

Using ultrasonic duplex scanning, volumetric blood flow (VBF) in the common carotid artery (CCA) was studied in 119 healthy subjects (73 males and 46 females), aged 20-75. With age, mean linear flow rate seems to undergo slowing down, while CCA diameter becomes wider. However, VBF in CCA in the middle-aged and elderly subjects decreased insignificantly. Males have larger CCA diameters and, consequently, greater VBF. A correlation exists between head circumference measured horizontally 2 cm above the superciliary arches and CCA diameter. This explains higher VBF in CCA in subjects with greater head circumference.

Adult↗
PubMed1994

[Hemodynamic changes in patients with large postoperative ventral hernias].

Hemodynamic parameters have been analyzed in 68 inpatients with large postoperative ventral hernia. Most of the patients showed normodynamic circulation. The artificial rise of the intra-abdominal pressure in the course of the preoperative preparation induced hypodynamic response of the cardiovascular system. Early after the surgery, the patients had hypodynamic circulation. As compared to induced abdominal hypertension, this hypodynamia was less pronounced indicating adaptation of the cardiac activity to preoperative hypertension. This is confirmed by the absence of complications related to high intraabdominal pressure in early postoperative period.

Adult↗