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Z S Tolochko

Publications and source records attributed to Z S Tolochko.

16 recordsLinked to original sources
PubMed2003

Effects of stimulation of the trigeminal caudal nucleus on microvascular permeability in the eye in normal and capsaicin-treated rats.

Electrical stimulation of the trigeminal caudal nucleus in rats evoked increases in the permeability of eye microvessels. The microvascular effect did not appear when the nucleus was stimulated after administration of capsaicin 10 days before surgery (total dose 150 mg/kg, s.c., on two sequential days, given as 20, 30, 50, and 50 mg/kg). It is suggested that capsaicin-sensitive neurons in the trigeminal ganglion mediate the microvascular effect of stimulation of the trigeminal caudal nucleus.

Animals↗
PubMed2003

[Comparative characteristic of serpin--alpha-1 proteinase inhibitor in human and mice serum].

Serpin alpha-1-proteinase inhibitor have been studied in human subjects and in mice of different lines as acute phase reactant and during tumor development. In humans, there was no difference of serpin activity between men and women. Increased activity was noted in men with acute trauma (acute phase reaction). Comparatively to male, in female mice of different lines decreased activity of serum alpha-1-proteinase inhibitor, was shown. There was no increase of alpha-1-proteinase inhibitor activity during inflammation induced by zymosan administration in mice. alpha-1-proteinase inhibitor belongs to acute phase reactants in humans but not in mice; for mice alpha-2-macroglobulin is a more typical acute phase reactant as compared to alpha-1-proteinase inhibitor. Murine tumor development (hepatoma HA-1, lymphosarcoma LS, Lewis lung adenocarcinoma) was followed by a decreased activity of serum alpha-1-proteinase inhibitor both in successfully treated and untreated groups. According to data of literature, similar dated were obtained in humans with tumors. It was suggested that changes of expressiln of alpha-1-proteinase inhibitor by tumors and its secretion were involved in decreased activity of alpha-1-proteinase inhibitor.

Adolescent↗
PubMed2002

[Effect of electrical stimulation of the trigeminal nucleus caudatus on the blood microvessel permeability in the eye in normal and capsaicin-treated rats].

Electrical stimulation of the trigeminal caudate nucleus increased permeability of the eye blood microvessels in rats. Ten days after capsaicin pre-treatment (total dose 150 mg/kg, s/c for 2 days: 20, 30, 50, 50 mg/kg) the electrical stimulation did not evoke any changes of the microvascular permeability in the eye. The data suggest that the effect of the stimulation is mediated through capsaicin-sensitive neurones of the trigeminal ganglion.

Animals↗
PubMed2001

[Changes in the skin microvessel permeability following destruction of the mamillary-tegmental tract in normal and capsaicin-treated rats].

An increase in vascular permeability as measured by the Evans Blue dye leakage into forepaws, was observed 1 hour following the destruction of mamillo-tegmental tracts in rats. Ten days after capsaicin pre-treatment the destruction did not induce any changes of the microvascular permeability in the skin forepaws. The findings suggest that the descending projections of hypothalamic mamillary nuclei might regulate the mechanisms of the skin microvessel permeability, the action being mediated through capsaicinsensitive neurons of the spinal ganglion.

Animals↗
PubMed1997

Effect of lesion of the hypothalamic mamillary nuclei on skin blood vessel permeability in normal and capsaicin-pretreated rats.

Contralateral increased exudation of plasma proteins, as measured by Evans Blue leakage into the fore paws, was produced by unilateral electrocoagulation of the mamillary nuclei in rats. Ten days after adult capsaicin pretreatment (increasing doses/4 days total 200 mg/kg, s.c.) the unilateral destruction of these nuclei did not evoke any changes of skin blood vessel permeability in both contralateral and unilateral paws. The findings show that the central nervous system may modulate the capsaicin-sensitive peptidergic neuron action on blood vessel permeability.

Animals↗
PubMed1997

[The role of leukocytic infiltration in the development of neurogenic processes in the denervated rat cornea].

In early and late stages after different types of deafferentation of rat cornea extents of leukocyte infiltration and pathological changes are variable. Change of thickness of anterior epithelium and substantia propria, stratification of substantia propria fibres as well as epitheliocyte death and erosion occur only at late time intervals of deafferentation (after 1 d) when a large number of leukocytes appear in cornea. One day after the deafferentation performed following preliminary leukopoiesis suppression by irradiation, single leukocytes are encountered only in substantia propria of cornea while anterior epithelium thickness does not differ from that of intact animals, and the extent of pathological changes in substantia propria is reduced. These data demonstrate polymorphonuclear leukocyte participation in the development of neurogenic dystrophia in cornea.

Afferent Pathways↗
PubMed1991

Trophic functions of primary sensory neurons: are they really local?

The results of the present study, in the rat and cat, indicate that not only a lesion of peripheral nerve or capsaicin pretreatment but also pharmacological deafferentation with local anaesthetic or disruption of the connections between primary sensory neurons and the central nervous system are effective in producing dystrophic changes in tissues. These effects of deafferentation do not seem to depend on the sympathetic or parasympathetic efferents. Dystrophic changes are connected with microcirculation disturbances: slow down of local blood flow, elevation of the vascular permeability, oedema and leucocyte infiltration. The findings indicate that capsaicin-sensitive primary sensory neurons are the afferent part of some reflex arrangement which participates in the regulation of microcirculation and the maintenance of trophic processes in peripheral tissues. The efferent part of this arrangement is unknown.

Animals↗
PubMed1981

[Emotional-defensive behavior and noradrenergic forebrain structures].

Conditioned avoidance responses in rats increase the noradrenaline expenditure in forebrain. The animals which reproduce no conditioned response after learning as well as the animals with ECS-induced retrograde amnesia preserve the noradrenergic terminals reaction as well as the emotional component of the conditioned response. The extinction of the emotional component by repeated testing or diazepam administration decreases the noradrenergic terminals activation. The data obtained support the view of the noradrenergic system participation in emotional--defensive behaviour.

Amnesia, Retrograde↗
PubMed1981

[Participation of hypothalamic noradrenergic structures in the reproduction of conditioned "passive" avoidance reactions].

The level of fluorescence of noradrenaline in the hypothalamic nuclei was studied with histofluorescent method during reproduction of conditioned reaction of passive avoidance (CPA) by rats of the Wistar line. Animals' "emotionality" was estimated by the number of defecation boluses. Reproduction of CPA in the first rest leads both to an increase in animals' "emotionality" and to an activation of noradrenergic terminals of the hypothalamic nuclei. After extinction of the emotional component of the conditioned reaction reproduction of CPA motor component does not lower the level of noradrenaline fluorescence in the studied structures. The obtained data permit to suggest participation of noradrenergic system in the emotional component of conditioned defensive reactions.

Animals↗
PubMedDate not supplied

Effect of electrical stimulation of the mamillary nuclei of the hypothalamus on skin vessel permeability in intact and capsaicin-treated rats.

Stimulation of the mamillary nuclei of the rat hypothalamus induced increases in the permeability of forelimb skin microvessels. This effect was not seen in rats stimulated after administration of capsaicin at a dose (150 mg/kg) sufficient to deplete vasoactive neuropeptides from the peripheral nerve terminals of capsaicin-sensitive neurons. These data indicate a role for the mamillary nuclei in central mechanisms modulating the effector functions of primary capsaicin-sensitive neurons.

Animals↗
PubMedDate not supplied

[Effect of damages of capsaicin-sensitive nerves on alpha1-antitrypsin activity in the rat blood].

Systemic administration of capsaicin (a neurotoxin of afferent nerves) in a dose of 150 mg/kg led to a decrease in the activity of alpha 1-antitrypsin (alpha 1-AT) in the blood of male Wistar rats. This effect is related to impairment of the local effector function of capsaicin-sensitive nerves in the liver, which is the main source of alpha 1-AT in the blood. Analogous results were obtained upon cutting of the hepatic branch of the vagus nerve involving capsaicin-sensitive afferent fibers of the liver.

Animals↗
PubMedDate not supplied

[A change in the permeability of eye microvasculature during damage to the hypothalamic nuclei in intact and rats and rats pretreated with capsaicin].

The destruction of rat hypothalamic mamillary nuclei causes impaired permeability of eye microvessels receiving afferent innervation from the trigeminal ganglion. This effect was eliminated by pre-treatment of the animals with capsaicin (200 mg/kg), which exhausted the content of substance P and calcitonin-gene-specific peptide, from the primary capsaicin-sensitive neurons of trigeminal and spinal ganglia. The findings show that the peripheral effect caused by the destruction of mamillary nuclei is mediated through capsaicin-sensitive neurons of the trigeminal ganglion.

Animals↗