Properties of particles prepared from sarcoplasmic reticulum by deoxycholate.
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Adenosine Triphosphatases↗
Biomedical subjects
Z Selinger
Publications and source records attributed to Z Selinger.
Calcium binding properties of sarcoplasmic reticulum membranes.
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Adenosine Triphosphatases↗
Synthesis of fatty acid anhydrides by reaction with dicyclohexylcarbodiimide.
A simple method is described for the preparation of caprylic, palmitic, stearic, and oleic anhydrides. Reaction of the free fatty acid and dicyclohexylcarbodiimide in carbon tetrachloride at room temperature gives the corresponding anhydrides in high yield (87-94%).
Anhydrides↗
A new synthesis of phosphatidic acids by direct acylation of DL-alpha-glycerophosphate.
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Chemical Phenomena↗
The effects of trans, trans-linoleate upon the metabolism of linoleate and linolenate and the positional distribution of linoleate isomers in liver lecithin.
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Animals↗
Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11.
Novel backbone-to-side chain and backbone-to-backbone cyclic analogues of substance P (SP) were prepared by solid-phase synthesis and screened for biological activity. An analogue containing a thioetherlactam ring between positions 9 and 11 showed an EC50 value of 20 nM toward the neurokinin 1 (NK-1) and was inactive toward the NK-2 and NK-3 receptors. On the other hand, in a multiple backbone cyclic peptide library of similar analogues, in which the sulphur was excluded from the ring, very low activity was detected. The activity was re-evaluated and was found to be even lower (EC50 = 0.11 mM) than the previously published data. These results indicate that the thioether moiety has a crucial role in receptor activation. The results also show tolerance of the NK-1 receptor, but not NK-2 or NK-3, to cyclization of the C-terminal portion of the SP6-11 hexapeptide.
Animals↗