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Biomedical subjects

Z Slezák

Publications and source records attributed to Z Slezák.

At least 19 recordsLinked to original sources
PubMed1990

Therapeutic methods of digestive endoscopy in persons of advanced age.

Towards the end of 1988, 85 out of 170 patients indicated for endoscopic papillotomy (EPT) were over 65 years of age, and, of these, 54% were 75 and more. EPT was successful in 90.6% of those over 65. Total morbidity was 4.7% and mortality 1.2%. Endoscopic colorectal polypectomy (EPE) was performed during the same period in 591 subjects. 143 of them (24.2%) were over 65 and had a total of 284 polyps removed. Almost half those polyps were more than 10 mm in diameter. Adenomas of the right colon were at least 3 times as frequent as in asymptomatic subjects aged 45-60 years revealed by screening for colorectal neoplasms in HaemocultR-positive subjects. Particular attention was devoted to patients with malignant polyps and with very broadly sessile adenomas--both could definitively be treated with the endoscopic method. EPT is often the only possible therapy for elderly and high-risk patients. Every colorectal polyp should be evaluated by endoscopy, and EPE, especially in patients of advanced age, is the method of choice when technically feasible.

Aged↗
PubMed1990

[Pancreatic tumors with endocrine activity in adolescents].

The authors demonstrate three patients--two with a nesidioma of the B-cells with insulin production, the third had a nesidioma made up of non-B cells with clinical manifestations of gastrin hypersecretion. The surgical solution was successful in the patients with B-cell nesiodiomas.

Adolescent↗
PubMed1989

[Therapeutic methods of digestive tract endoscopy in older persons].

By the end of 1988 of 170 patients indicated for endoscopic papillotomy (EPT) 85 subjects were above 65 years of age and of these 54% were 75 years old or above that age. EPT was successful in 90.6% of subjects above 65 years of age. The total morbidity was 4.7% and the mortality 1.2%. Endoscopic colorectal polypectomy (EPE) was performed during the same period in 591 subjects. Of these 143 (24.2%) were above 65 years and in these subjects 284 polyps were removed. Almost half the polyps in these patients had a diameter of more than 10 mm, and adenomas of the right colon were at least three times more frequent than in asymptomatic subjects aged 45-60 years revealed by screening of colorectal neoplasms in HaemocultR-positive subjects. Special attention was devoted to patients with malignant polyps and with very broadly attached adenomas of the left colon. Almost three quarters of patients with very broadly attached adenomas could be definitely treated by the endoscopic method. EPT is in many instances the only possible therapeutic approach in old and risk patients. Every colorectal polyp should be evaluated by endoscopy and EPE is in particular in subjects of advanced age the method of choice, when technically feasible.

Aged↗
PubMed1977

Intestinal gradient of enterokinase activity in different species of animals.

The proximodistal gradient of enterokinase activity was studied in mucosal homogenates of the duodenum, jejunum, ileum, caecum (or megacaecum) and sigmoid flexure of various mammals. The study was carried out in groups of 5 monkeys, guinea pigs, dogs and rats and also in gnotobiological rats--conventional (n = 5), germ-free (n = 10) and monocontaminated (n = 5) with Escherichia coli 0 86. Enterokinase activity was likewise determined in duodenal mucosal homogenates prepared from material resected at operation from adult humans (n = 5) and from a group of monkeys (n = 5), with and without the addition of Triton X-100. Enzymatic activity was determined by a modification of Nordström and Dahlqvist's method, using pH-stat titration. In all the animals, enterokinase values were unequivocally the highest in the duodenal mucosa; in the other intestinal segments it displayed a marked aboral decrease, so that we found about 30% of duodenal activity in the jejunum, trace amounts in the ileum and zero values in the caecum and the sigmoid flexure. In the individual animals, the enterokinase activity values fell in the sequence monkey greater than guinea-pig greater than dog greater than rat. Enterokinase activity in the human duodenum was practically the same as in the rat duodenal mucosa. No reciprocal differences were found in gnotobiological rats. Either whole homogenate or the supernatant of triton-treated homogenate can be used for the demonstration of enterokinase in laboratory practice. The only part which can be employed for diagnostic purposes in duodenal mucosa.

Animals↗